The ever-increasing number of sequenced genomes presents us with an exciting opportunity to discover highly conserved gene families of unknown function, then characterize them experimentally. We have detected these gene families across the kingdom Fungi (see Methods at the bottom of this page), and invite the international research community to functionally characterize their individual members and propagate their annotations across the Fungal Tree of Life. Investigators can register, login, click on any cluster below (the number of the left), and add notes to any protein from the list along with the methods used for functional characterization.
## | Genes | Expressed Genes % | Genes with Phenotypes | Unique Species | Proteins with PFAM Domains | Unique PFAM Domains Count | Protein PFAM Domains | Uniprot HMM Hint | PDB HMM Hint | AlphaFold pLDDT | Foldseek PDB Hint | Conserved In | User Curated Models | Avg. Protein Length |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | 1,641 | 84 | 1 | 461 | 0 | 0 | 78 | Fungi | 0 | 244 | ||||
2 | 1,348 | 50 | 1 | 726 | 2 | 2 | 2OG-Fe dioxygenase: 1 2OG-Fe(II) oxygenase superfamily:1 | 88 | Universal | 0 | 356 | |||
3 | 1,301 | 85 | 0 | 356 | 32 | 2 | Arrestin (or S-antigen), N-terminal domain: 31 REV protein (anti-repression trans-activator protein):1 | 86 | Fungi | 0 | 423 | |||
4 | 1,127 | 67 | 1 | 1,067 | 0 | 0 | 90 | Fungi and Viridiplantae | 0 | 148 | ||||
5 | 1,063 | 60 | 0 | 560 | 0 | 0 | 76 | Fungi | 0 | 379 | ||||
6 | 1,045 | 60 | 0 | 730 | 0 | 0 | 82 | Eukaryota | 0 | 220 | ||||
7 | 969 | 81 | 0 | 362 | 0 | 0 | 75 | Fungi | 0 | 326 | ||||
8 | 967 | 65 | 0 | 947 | 0 | 0 | 81 | Fungi and Viridiplantae | 0 | 118 | ||||
9 | 956 | 60 | 0 | 916 | 0 | 0 | 61 | Universal | 0 | 495 | ||||
10 | 951 | 61 | 0 | 921 | 0 | 0 | 60 | Eukaryota | 0 | 641 | ||||
11 | 944 | 61 | 0 | 929 | 1 | 1 | SOS response associated peptidase (SRAP): 1 | 71 | Fungi and Viridiplantae | 0 | 391 | |||
12 | 940 | 63 | 0 | 931 | 0 | 0 | 83 | Fungi and Viridiplantae | 0 | 303 | ||||
13 | 925 | 59 | 0 | 864 | 0 | 0 | 51 | Universal | 0 | 397 | ||||
14 | 920 | 62 | 0 | 911 | 0 | 0 | 82 | Universal | 0 | 354 | ||||
15 | 915 | 64 | 0 | 898 | 0 | 0 | 76 | Fungi and Viridiplantae | 0 | 183 | ||||
16 | 913 | 64 | 0 | 904 | 2 | 1 | Membrane-associating domain: 2 | 74 | Eukaryota | 0 | 203 | |||
17 | 910 | 63 | 0 | 892 | 0 | 0 | 58 | Fungi and Viridiplantae | 0 | 1,106 | ||||
18 | 899 | 64 | 0 | 724 | 0 | 0 | 90 | Fungi and Viridiplantae | 0 | 114 | ||||
19 | 897 | 62 | 0 | 885 | 0 | 0 | 50 | Eukaryota | 0 | 430 | ||||
20 | 895 | 62 | 0 | 873 | 0 | 0 | 60 | Fungi and Viridiplantae | 0 | 501 | ||||
21 | 895 | 65 | 0 | 890 | 0 | 0 | 67 | Fungi | 0 | 397 | ||||
22 | 894 | 63 | 0 | 888 | 0 | 0 | 86 | Fungi | 0 | 305 | ||||
23 | 893 | 62 | 0 | 885 | 1 | 1 | Cytochrome c oxidase biogenesis protein Cmc1 like: 1 | 83 | Eukaryota | 0 | 323 | |||
24 | 888 | 63 | 0 | 882 | 0 | 0 | 68 | Fungi and Viridiplantae | 0 | 325 | ||||
25 | 880 | 61 | 0 | 840 | 0 | 0 | 96 | Fungi | 0 | 183 | ||||
26 | 879 | 73 | 1 | 839 | 45 | 2 | NAD dependent epimerase/dehydratase family: 25 NAD(P)H-binding:20 | 91 | Fungi and Viridiplantae | 0 | 299 | |||
27 | 872 | 61 | 0 | 848 | 0 | 0 | 45 | Fungi and Viridiplantae | 0 | 420 | ||||
28 | 867 | 64 | 0 | 857 | 0 | 0 | 50 | Universal | 0 | 563 | ||||
29 | 865 | 62 | 1 | 843 | 5 | 1 | Bombesin-like peptide: 5 | 78 | Eukaryota | 0 | 290 | |||
30 | 864 | 61 | 0 | 829 | 1 | 1 | Atrophin-1 family: 1 | 58 | Fungi and Viridiplantae | 0 | 684 | |||
31 | 861 | 62 | 0 | 850 | 0 | 0 | 80 | Fungi and Viridiplantae | 0 | 624 | ||||
32 | 858 | 60 | 0 | 834 | 0 | 0 | 76 | Fungi and Viridiplantae | 0 | 225 | ||||
33 | 846 | 63 | 0 | 759 | 0 | 0 | 78 | Fungi and Viridiplantae | 0 | 227 | ||||
34 | 842 | 64 | 0 | 831 | 0 | 0 | 61 | Fungi | 0 | 278 | ||||
35 | 840 | 65 | 0 | 827 | 0 | 0 | 58 | Fungi and Viridiplantae | 0 | 391 | ||||
36 | 838 | 65 | 1 | 829 | 2 | 1 | Peptidase family M41: 2 | 60 | Universal | 0 | 409 | |||
37 | 837 | 64 | 0 | 820 | 0 | 0 | 68 | Fungi and Viridiplantae | 0 | 590 | ||||
38 | 837 | 63 | 0 | 829 | 0 | 0 | 57 | Universal | 0 | 438 | ||||
39 | 834 | 62 | 0 | 793 | 0 | 0 | 78 | Fungi and Viridiplantae | 0 | 964 | ||||
40 | 833 | 59 | 0 | 815 | 0 | 0 | 79 | Eukaryota | 0 | 263 | ||||
41 | 831 | 67 | 0 | 719 | 0 | 0 | 91 | Fungi and Viridiplantae | 0 | 162 | ||||
42 | 830 | 63 | 0 | 809 | 0 | 0 | 69 | Fungi and Viridiplantae | 0 | 365 | ||||
43 | 826 | 64 | 0 | 805 | 0 | 0 | 55 | Fungi and Viridiplantae | 0 | 527 | ||||
44 | 824 | 67 | 0 | 817 | 0 | 0 | 68 | Fungi and Viridiplantae | 0 | 182 | ||||
45 | 820 | 66 | 1 | 810 | 24 | 1 | Glutathione-dependent formaldehyde-activating enzyme: 24 | 71 | Eukaryota | 0 | 250 | |||
46 | 817 | 63 | 0 | 802 | 103 | 1 | Altered inheritance of mitochondria protein 19: 103 | 79 | Fungi and Viridiplantae | 0 | 137 | |||
47 | 814 | 65 | 0 | 806 | 0 | 0 | 68 | Universal | 0 | 596 | ||||
48 | 813 | 66 | 0 | 800 | 0 | 0 | 71 | Fungi | 0 | 284 | ||||
49 | 812 | 63 | 0 | 793 | 0 | 0 | 69 | Universal | 0 | 176 | ||||
50 | 811 | 64 | 0 | 782 | 2 | 1 | BLOC-1-related complex sub-unit 6 C-terminal helix: 2 | 78 | Fungi and Viridiplantae | 0 | 169 | |||
51 | 804 | 64 | 0 | 767 | 1 | 1 | HupE / UreJ protein: 1 | 87 | Fungi and Viridiplantae | 0 | 179 | |||
52 | 804 | 68 | 0 | 796 | 0 | 0 | 75 | Fungi | 0 | 341 | ||||
53 | 803 | 65 | 0 | 798 | 0 | 0 | 68 | Eukaryota | 0 | 424 | ||||
54 | 798 | 59 | 0 | 779 | 1 | 1 | Protein of unknown function (DUF4030): 1 | 68 | Fungi and SAR | 0 | 136 | |||
55 | 798 | 63 | 0 | 772 | 0 | 0 | 71 | Fungi and Viridiplantae | 0 | 536 | ||||
56 | 797 | 63 | 0 | 790 | 0 | 0 | 79 | Fungi | 0 | 240 | ||||
57 | 795 | 62 | 0 | 786 | 0 | 0 | 46 | Fungi and Viridiplantae | 0 | 656 | ||||
58 | 790 | 64 | 0 | 781 | 0 | 0 | 79 | Eukaryota | 0 | 565 | ||||
59 | 790 | 65 | 0 | 784 | 0 | 0 | 78 | Fungi and Viridiplantae | 0 | 295 | ||||
60 | 789 | 64 | 0 | 785 | 0 | 0 | 75 | Fungi and Viridiplantae | 0 | 415 | ||||
61 | 789 | 58 | 0 | 780 | 0 | 0 | 82 | Universal | 0 | 683 | ||||
62 | 783 | 62 | 1 | 767 | 0 | 0 | 49 | Fungi and Prokaryotes | 0 | 528 | ||||
63 | 781 | 64 | 0 | 736 | 0 | 0 | 51 | Eukaryota | 0 | 562 | ||||
64 | 781 | 65 | 0 | 774 | 0 | 0 | 82 | Fungi and Viridiplantae | 0 | 351 | ||||
65 | 779 | 78 | 1 | 577 | 2 | 1 | Fungal protein of unknown function (DUF1774): 2 | 90 | Fungi | 0 | 270 | |||
66 | 772 | 60 | 0 | 764 | 0 | 0 | 81 | Universal | 0 | 638 | ||||
67 | 770 | 65 | 0 | 764 | 0 | 0 | 57 | Fungi and SAR | 0 | 439 | ||||
68 | 767 | 85 | 0 | 407 | 1 | 1 | COPI associated protein: 1 | 74 | Fungi | 0 | 279 | |||
69 | 762 | 66 | 0 | 746 | 0 | 0 | 53 | Fungi | 0 | 266 | ||||
70 | 747 | 61 | 0 | 715 | 0 | 0 | 79 | Fungi and Viridiplantae | 0 | 560 | ||||
71 | 745 | 66 | 0 | 743 | 0 | 0 | 65 | Eukaryota | 0 | 451 | ||||
72 | 739 | 64 | 0 | 735 | 0 | 0 | 71 | Fungi and Viridiplantae | 0 | 120 | ||||
73 | 736 | 63 | 0 | 734 | 0 | 0 | 69 | Eukaryota | 0 | 526 | ||||
74 | 730 | 64 | 0 | 718 | 0 | 0 | 73 | Fungi and SAR | 0 | 522 | ||||
75 | 729 | 68 | 0 | 712 | 0 | 0 | 64 | Fungi | 0 | 150 | ||||
76 | 729 | 66 | 0 | 722 | 1 | 1 | Prefoldin subunit: 1 | 64 | Eukaryota | 0 | 1,017 | |||
77 | 725 | 81 | 0 | 378 | 0 | 0 | 89 | Eukaryota | 0 | 319 | ||||
78 | 723 | 86 | 0 | 357 | 0 | 0 | 90 | Fungi | 0 | 188 | ||||
79 | 723 | 56 | 0 | 662 | 0 | 0 | 70 | Fungi and Viridiplantae | 0 | 342 | ||||
80 | 720 | 71 | 0 | 715 | 0 | 0 | 56 | Fungi and Viridiplantae | 0 | 484 | ||||
81 | 715 | 63 | 0 | 700 | 0 | 0 | 68 | Eukaryota | 0 | 289 | ||||
82 | 697 | 66 | 0 | 697 | 0 | 0 | 63 | Fungi | 0 | 333 | ||||
83 | 685 | 66 | 0 | 662 | 0 | 0 | 85 | Fungi | 0 | 329 | ||||
84 | 677 | 66 | 0 | 670 | 0 | 0 | 77 | Fungi | 0 | 334 | ||||
85 | 677 | 62 | 0 | 672 | 5 | 3 | AT hook motif: 2 Leucine Rich Repeat:2 Leucine Rich Repeat:1 | 71 | Fungi and Viridiplantae | 0 | 716 | |||
86 | 672 | 61 | 0 | 655 | 0 | 0 | 66 | Fungi and SAR | 0 | 284 | ||||
87 | 668 | 60 | 0 | 659 | 8 | 2 | F-box domain: 7 F-box-like:1 | 73 | Fungi | 0 | 592 | |||
88 | 665 | 65 | 0 | 661 | 0 | 0 | 83 | Fungi | 0 | 152 | ||||
89 | 660 | 59 | 0 | 651 | 0 | 0 | 61 | Eukaryota | 0 | 410 | ||||
90 | 657 | 72 | 1 | 633 | 1 | 1 | F-box-like: 1 | 89 | Fungi and Viridiplantae | 0 | 544 | |||
91 | 651 | 57 | 0 | 619 | 0 | 0 | 71 | Fungi and Viridiplantae | 0 | 360 | ||||
92 | 643 | 68 | 0 | 629 | 0 | 0 | 90 | Fungi and Viridiplantae | 0 | 183 | ||||
93 | 621 | 60 | 0 | 612 | 0 | 0 | 64 | Eukaryota | 0 | 271 | ||||
94 | 614 | 66 | 0 | 554 | 0 | 0 | 78 | Universal | 0 | 823 | ||||
95 | 612 | 64 | 0 | 608 | 0 | 0 | 57 | Fungi and Viridiplantae | 0 | 1,169 | ||||
96 | 610 | 65 | 0 | 601 | 0 | 0 | 57 | Fungi and Viridiplantae | 0 | 374 | ||||
97 | 610 | 67 | 0 | 610 | 0 | 0 | 50 | Fungi | 0 | 329 | ||||
98 | 601 | 66 | 0 | 574 | 0 | 0 | 62 | Fungi and Viridiplantae | 0 | 373 | ||||
99 | 599 | 57 | 0 | 590 | 1 | 1 | Metchnikowin family: 1 | 58 | Universal | 0 | 240 | |||
100 | 594 | 64 | 0 | 588 | 0 | 0 | 78 | Fungi and Viridiplantae | 0 | 569 | ||||
101 | 594 | 59 | 0 | 591 | 0 | 0 | 81 | Eukaryota | 0 | 596 | ||||
102 | 592 | 75 | 1 | 445 | 95 | 1 | Domain of unknown function (DUF4336): 95 | 95 | Fungi | 0 | 252 | |||
103 | 591 | 67 | 0 | 586 | 0 | 0 | 62 | Eukaryota | 0 | 1,711 | ||||
104 | 586 | 67 | 0 | 585 | 1 | 1 | Coiled-coil domain-containing protein 34: 1 | 56 | Fungi and SAR | 0 | 408 | |||
105 | 580 | 58 | 1 | 578 | 0 | 0 | 68 | Fungi and Viridiplantae | 0 | 357 | ||||
106 | 577 | 57 | 0 | 531 | 0 | 0 | 73 | Eukaryota | 0 | 1,096 | ||||
107 | 576 | 61 | 0 | 572 | 0 | 0 | 72 | Universal | 0 | 325 | ||||
108 | 571 | 64 | 0 | 562 | 0 | 0 | 79 | Fungi and Viridiplantae | 0 | 218 | ||||
109 | 566 | 51 | 0 | 294 | 0 | 0 | 71 | Fungi | 0 | 393 | ||||
110 | 563 | 66 | 0 | 560 | 0 | 0 | 58 | Fungi and Viridiplantae | 0 | 233 | ||||
111 | 558 | 66 | 0 | 557 | 0 | 0 | 72 | Fungi and Viridiplantae | 0 | 308 | ||||
112 | 551 | 84 | 0 | 345 | 0 | 0 | 82 | Fungi | 0 | 182 | ||||
113 | 544 | 68 | 0 | 531 | 1 | 1 | AN1-like Zinc finger: 1 | 63 | Fungi and Viridiplantae | 0 | 156 | |||
114 | 541 | 65 | 0 | 534 | 2 | 1 | Small acid-soluble spore protein P family: 2 | 58 | Fungi and Viridiplantae | 0 | 435 | |||
115 | 541 | 60 | 0 | 524 | 1 | 1 | Protein of unknown function (DUF1698): 1 | 93 | Fungi and Viridiplantae | 0 | 397 | |||
116 | 539 | 68 | 0 | 537 | 0 | 0 | 75 | Fungi and Viridiplantae | 0 | 236 | ||||
117 | 535 | 67 | 0 | 529 | 1 | 1 | Insulinase (Peptidase family M16): 1 | 81 | Fungi | 0 | 771 | |||
118 | 531 | 70 | 0 | 529 | 0 | 0 | 79 | Fungi and Viridiplantae | 0 | 172 | ||||
119 | 527 | 63 | 0 | 520 | 0 | 0 | 70 | Fungi | 0 | 117 | ||||
120 | 510 | 62 | 0 | 505 | 0 | 0 | 55 | Fungi and Viridiplantae | 0 | 641 | ||||
121 | 510 | 87 | 0 | 354 | 0 | 0 | 90 | Fungi and Viridiplantae | 0 | 203 | ||||
122 | 508 | 62 | 0 | 501 | 0 | 0 | 58 | Eukaryota | 0 | 866 | ||||
123 | 505 | 65 | 0 | 499 | 0 | 0 | 70 | Fungi and Viridiplantae | 0 | 456 | ||||
124 | 499 | 62 | 0 | 481 | 0 | 0 | 78 | Universal | 0 | 379 | ||||
125 | 494 | 69 | 0 | 493 | 5 | 2 | PPR repeat: 4 Pentatricopeptide repeat domain:1 | 76 | Fungi and Viridiplantae | 0 | 806 | |||
126 | 478 | 72 | 0 | 465 | 0 | 0 | 73 | Fungi and Viridiplantae | 0 | 167 | ||||
127 | 465 | 55 | 0 | 411 | 0 | 0 | 53 | Fungi | 0 | 599 | ||||
128 | 464 | 81 | 1 | 389 | 0 | 0 | 93 | Fungi | 0 | 176 | ||||
129 | 461 | 69 | 0 | 457 | 12 | 4 | F-box domain: 9 Protein of unknown function (DUF2442):1 Serum albumin family:1 F-box-like:1 | 78 | Fungi and Viridiplantae | 0 | 507 | |||
130 | 460 | 70 | 1 | 429 | 0 | 0 | 85 | Fungi | 0 | 192 | ||||
131 | 454 | 84 | 0 | 399 | 303 | 1 | Protein of unknown function (DUF1308): 303 | 80 | Fungi | 0 | 610 | |||
132 | 450 | 58 | 0 | 423 | 0 | 0 | 56 | Fungi and SAR | 0 | 388 | ||||
133 | 448 | 71 | 0 | 321 | 0 | 0 | 92 | Fungi | 0 | 160 | ||||
134 | 444 | 64 | 0 | 443 | 0 | 0 | 78 | Fungi | 0 | 411 | ||||
135 | 443 | 66 | 0 | 439 | 0 | 0 | 87 | Fungi and Viridiplantae | 0 | 634 | ||||
136 | 438 | 86 | 0 | 347 | 20 | 1 | 4'-phosphopantetheinyl transferase superfamily: 20 | 92 | Fungi | 0 | 289 | |||
137 | 437 | 66 | 0 | 434 | 0 | 0 | 62 | Eukaryota | 0 | 257 | ||||
138 | 432 | 66 | 0 | 406 | 0 | 0 | 76 | Fungi | 0 | 222 | ||||
139 | 431 | 87 | 0 | 363 | 0 | 0 | 89 | Fungi | 0 | 301 | ||||
140 | 429 | 82 | 0 | 399 | 0 | 0 | 73 | Fungi | 0 | 259 | ||||
141 | 428 | 66 | 0 | 423 | 4 | 1 | PT repeat: 4 | 60 | Eukaryota | 0 | 449 | |||
142 | 426 | 84 | 0 | 398 | 0 | 0 | 83 | Fungi | 0 | 382 | ||||
143 | 423 | 63 | 0 | 421 | 0 | 0 | 58 | Universal | 0 | 716 | ||||
144 | 418 | 86 | 0 | 375 | 0 | 0 | 88 | Fungi | 0 | 205 | ||||
145 | 417 | 83 | 0 | 399 | 0 | 0 | 85 | Fungi and Viridiplantae | 0 | 316 | ||||
146 | 416 | 82 | 0 | 405 | 0 | 0 | 70 | Fungi | 0 | 290 | ||||
147 | 414 | 85 | 0 | 388 | 0 | 0 | 82 | Fungi and Viridiplantae | 0 | 634 | ||||
148 | 411 | 62 | 0 | 407 | 0 | 0 | 55 | Fungi | 0 | 534 | ||||
149 | 409 | 63 | 0 | 409 | 0 | 0 | 63 | Eukaryota | 0 | 603 | ||||
150 | 408 | 86 | 0 | 342 | 0 | 0 | 70 | Fungi | 0 | 236 | ||||
151 | 408 | 60 | 1 | 405 | 1 | 1 | Chromatin assembly factor 1 complex p150 subunit, N-terminal: 1 | 58 | Universal | 0 | 433 | |||
152 | 407 | 65 | 0 | 405 | 0 | 0 | 88 | Fungi | 0 | 370 | ||||
153 | 406 | 86 | 0 | 375 | 0 | 0 | 76 | Fungi | 0 | 157 | ||||
154 | 405 | 64 | 0 | 400 | 0 | 0 | 58 | Fungi | 0 | 472 | ||||
155 | 404 | 60 | 0 | 398 | 0 | 0 | 74 | Fungi | 0 | 531 | ||||
156 | 404 | 86 | 0 | 367 | 0 | 0 | 94 | Fungi | 0 | 182 | ||||
157 | 403 | 83 | 0 | 388 | 319 | 1 | WD domain, G-beta repeat: 319 | 89 | Fungi | 0 | 372 | |||
158 | 399 | 83 | 0 | 385 | 0 | 0 | 75 | Fungi | 0 | 309 | ||||
159 | 398 | 64 | 0 | 393 | 5 | 1 | Meiosis-specific protein Mei4: 5 | 72 | Fungi and Viridiplantae | 0 | 514 | |||
160 | 398 | 70 | 0 | 386 | 0 | 0 | 79 | Fungi and Viridiplantae | 0 | 524 | ||||
161 | 395 | 84 | 0 | 356 | 0 | 0 | 94 | Fungi and Viridiplantae | 0 | 208 | ||||
162 | 394 | 73 | 0 | 148 | 0 | 0 | 73 | Fungi and SAR | 0 | 222 | ||||
163 | 394 | 84 | 0 | 374 | 0 | 0 | 87 | Fungi | 0 | 232 | ||||
164 | 393 | 86 | 0 | 349 | 0 | 0 | 71 | Fungi | 0 | 316 | ||||
165 | 392 | 88 | 0 | 378 | 0 | 0 | 81 | Fungi | 0 | 197 | ||||
166 | 391 | 71 | 0 | 383 | 0 | 0 | 74 | Fungi | 0 | 406 | ||||
167 | 390 | 88 | 0 | 364 | 0 | 0 | 52 | Fungi and Viridiplantae | 0 | 470 | ||||
168 | 389 | 87 | 0 | 362 | 1 | 1 | Heme oxygenase: 1 | 78 | Fungi | 0 | 230 | |||
169 | 387 | 62 | 0 | 383 | 0 | 0 | 44 | Fungi | 0 | 1,052 | ||||
170 | 386 | 87 | 0 | 362 | 0 | 0 | 94 | Fungi | 0 | 194 | ||||
171 | 386 | 85 | 0 | 364 | 2 | 1 | SUR7/PalI family: 2 | 88 | Fungi | 0 | 235 | |||
172 | 385 | 85 | 0 | 370 | 192 | 2 | V-type proton ATPase subunit S1, luminal domain: 191 PF08319:1 | 80 | Fungi | 0 | 281 | |||
173 | 385 | 63 | 0 | 364 | 0 | 0 | 55 | Fungi and SAR | 0 | 603 | ||||
174 | 384 | 64 | 0 | 381 | 0 | 0 | 50 | Fungi | 0 | 325 | ||||
175 | 384 | 86 | 0 | 378 | 0 | 0 | 60 | Fungi | 0 | 782 | ||||
176 | 382 | 82 | 0 | 368 | 168 | 3 | Ankyrin repeats (3 copies): 139 Ankyrin repeat:29 Ankyrin repeats (many copies):2 | 86 | Fungi | 0 | 272 | |||
177 | 381 | 82 | 0 | 234 | 6 | 2 | EthD domain: 4 Antibiotic biosynthesis monooxygenase:2 | 95 | Universal | 0 | 235 | |||
178 | 380 | 62 | 0 | 370 | 2 | 1 | Chromatin assembly factor 1 complex p150 subunit, N-terminal: 2 | 49 | Fungi | 0 | 481 | |||
179 | 380 | 86 | 0 | 375 | 0 | 0 | 71 | Universal | 0 | 383 | ||||
180 | 378 | 66 | 0 | 377 | 1 | 1 | AT hook motif: 1 | 77 | Fungi | 0 | 167 | |||
181 | 374 | 89 | 0 | 358 | 0 | 0 | 80 | Fungi | 0 | 247 | ||||
182 | 373 | 85 | 0 | 364 | 0 | 0 | 78 | Fungi | 0 | 532 | ||||
183 | 372 | 88 | 0 | 364 | 0 | 0 | 60 | Fungi | 0 | 393 | ||||
184 | 371 | 64 | 0 | 369 | 0 | 0 | 81 | Fungi | 0 | 252 | ||||
185 | 371 | 88 | 0 | 335 | 0 | 0 | 85 | Fungi | 0 | 143 | ||||
186 | 371 | 87 | 0 | 354 | 0 | 0 | 76 | Fungi | 0 | 482 | ||||
187 | 370 | 71 | 0 | 368 | 0 | 0 | 53 | Fungi | 0 | 347 | ||||
188 | 370 | 88 | 0 | 336 | 2 | 2 | Nitrate and nitrite sensing: 1 Putative transmembrane protein:1 | 79 | Fungi | 0 | 203 | |||
189 | 370 | 87 | 0 | 364 | 0 | 0 | 63 | Fungi | 0 | 395 | ||||
190 | 369 | 85 | 0 | 354 | 0 | 0 | 72 | Fungi | 0 | 371 | ||||
191 | 368 | 62 | 0 | 367 | 0 | 0 | 77 | Fungi | 0 | 138 | ||||
192 | 367 | 87 | 0 | 360 | 0 | 0 | 88 | Fungi | 0 | 372 | ||||
193 | 366 | 60 | 0 | 364 | 0 | 0 | 72 | Eukaryota | 0 | 193 | ||||
194 | 365 | 87 | 0 | 337 | 0 | 0 | 93 | Fungi | 0 | 177 | ||||
195 | 364 | 85 | 0 | 344 | 0 | 0 | 64 | Fungi | 0 | 694 | ||||
196 | 364 | 84 | 0 | 344 | 0 | 0 | 59 | Fungi | 0 | 246 | ||||
197 | 364 | 85 | 0 | 340 | 29 | 3 | Leucine Rich repeat: 20 Leucine Rich Repeat:8 Leucine Rich Repeat:1 | 82 | Fungi | 0 | 714 | |||
198 | 363 | 75 | 0 | 361 | 0 | 0 | 70 | Fungi and Viridiplantae | 0 | 664 | ||||
199 | 363 | 87 | 0 | 350 | 0 | 0 | 62 | Fungi | 0 | 451 | ||||
200 | 359 | 84 | 1 | 345 | 0 | 0 | 80 | Fungi and Viridiplantae | 0 | 348 | ||||
201 | 359 | 89 | 0 | 342 | 1 | 1 | Protein of unknown function (DUF724): 1 | 58 | Fungi and Viridiplantae | 0 | 925 | |||
202 | 358 | 86 | 0 | 352 | 0 | 0 | 84 | Fungi | 0 | 296 | ||||
203 | 357 | 87 | 0 | 355 | 0 | 0 | 51 | Fungi and Viridiplantae | 0 | 948 | ||||
204 | 356 | 54 | 0 | 304 | 0 | 0 | 53 | Fungi | 0 | 448 | ||||
205 | 355 | 87 | 0 | 345 | 0 | 0 | 59 | Fungi | 0 | 863 | ||||
206 | 355 | 88 | 0 | 338 | 0 | 0 | 79 | Fungi | 0 | 674 | ||||
207 | 355 | 85 | 0 | 349 | 0 | 0 | 83 | Fungi | 0 | 437 | ||||
208 | 355 | 84 | 0 | 318 | 0 | 0 | 53 | Fungi and Viridiplantae | 0 | 334 | ||||
209 | 354 | 85 | 0 | 353 | 0 | 0 | 79 | Fungi and Viridiplantae | 0 | 527 | ||||
210 | 353 | 72 | 0 | 352 | 0 | 0 | 75 | Eukaryota | 0 | 260 | ||||
211 | 352 | 86 | 0 | 332 | 0 | 0 | 57 | Fungi | 0 | 213 | ||||
212 | 350 | 86 | 0 | 327 | 4 | 3 | Protein of unknown function (DUF1180): 2 Ykl077w/Psg1 (Pma1 Stabilization in Golgi):1 Glycophorin A:1 | 67 | Fungi and Viridiplantae | 0 | 428 | |||
213 | 350 | 84 | 0 | 344 | 0 | 0 | 88 | Fungi | 0 | 211 | ||||
214 | 349 | 88 | 0 | 346 | 0 | 0 | 60 | Fungi and Viridiplantae | 0 | 392 | ||||
215 | 349 | 87 | 0 | 342 | 0 | 0 | 82 | Fungi | 0 | 215 | ||||
216 | 347 | 64 | 0 | 335 | 0 | 0 | 71 | Fungi and Viridiplantae | 0 | 136 | ||||
217 | 346 | 84 | 0 | 335 | 0 | 0 | 57 | Fungi and Viridiplantae | 0 | 723 | ||||
218 | 344 | 86 | 0 | 336 | 0 | 0 | 57 | Fungi | 0 | 225 | ||||
219 | 343 | 87 | 0 | 329 | 0 | 0 | 83 | Fungi | 0 | 520 | ||||
220 | 341 | 85 | 0 | 338 | 1 | 1 | HSCB C-terminal oligomerisation domain: 1 | 68 | Fungi and Viridiplantae | 0 | 962 | |||
221 | 340 | 87 | 0 | 331 | 0 | 0 | 87 | Fungi | 0 | 152 | ||||
222 | 338 | 87 | 0 | 336 | 0 | 0 | 49 | Fungi | 0 | 434 | ||||
223 | 338 | 89 | 0 | 335 | 0 | 0 | 72 | Fungi | 0 | 313 | ||||
224 | 337 | 63 | 0 | 334 | 0 | 0 | 72 | Fungi and Viridiplantae | 0 | 1,019 | ||||
225 | 337 | 73 | 0 | 336 | 0 | 0 | 75 | Fungi | 0 | 194 | ||||
226 | 335 | 88 | 0 | 330 | 0 | 0 | 94 | Fungi | 0 | 130 | ||||
227 | 334 | 86 | 0 | 315 | 0 | 0 | 58 | Fungi | 0 | 480 | ||||
228 | 331 | 66 | 0 | 328 | 0 | 0 | 56 | Fungi | 0 | 263 | ||||
229 | 330 | 88 | 0 | 328 | 3 | 1 | Transient receptor potential (TRP) ion channel: 3 | 76 | Eukaryota | 0 | 1,157 | |||
230 | 330 | 86 | 0 | 330 | 0 | 0 | 72 | Fungi and Viridiplantae | 0 | 516 | ||||
231 | 328 | 87 | 0 | 306 | 0 | 0 | 71 | Fungi and Viridiplantae | 0 | 536 | ||||
232 | 328 | 63 | 0 | 325 | 0 | 0 | 49 | Fungi | 0 | 501 | ||||
233 | 328 | 86 | 0 | 324 | 0 | 0 | 45 | Fungi | 0 | 992 | ||||
234 | 327 | 85 | 0 | 324 | 0 | 0 | 54 | Fungi and Viridiplantae | 0 | 300 | ||||
235 | 323 | 88 | 0 | 321 | 1 | 1 | F-box domain: 1 | 88 | Fungi | 0 | 434 | |||
236 | 323 | 72 | 0 | 322 | 1 | 1 | Collagen triple helix repeat (20 copies): 1 | 66 | Fungi and Viridiplantae | 0 | 463 | |||
237 | 319 | 63 | 0 | 318 | 0 | 0 | 52 | Fungi | 0 | 453 | ||||
238 | 318 | 84 | 0 | 312 | 0 | 0 | 60 | Fungi | 0 | 220 | ||||
239 | 318 | 87 | 0 | 308 | 0 | 0 | 87 | Fungi | 0 | 341 | ||||
240 | 314 | 85 | 0 | 305 | 72 | 1 | DASH complex subunit Spc34: 72 | 64 | Fungi | 0 | 508 | |||
241 | 313 | 65 | 0 | 310 | 0 | 0 | 48 | Fungi | 0 | 679 | ||||
242 | 311 | 67 | 0 | 308 | 0 | 0 | 51 | Fungi and SAR | 0 | 363 | ||||
243 | 309 | 61 | 0 | 308 | 0 | 0 | 53 | Fungi and Viridiplantae | 0 | 974 | ||||
244 | 308 | 85 | 0 | 283 | 0 | 0 | 79 | Fungi | 0 | 153 | ||||
245 | 307 | 84 | 1 | 307 | 0 | 0 | 66 | Fungi and Prokaryotes | 0 | 473 | ||||
246 | 306 | 71 | 0 | 304 | 0 | 0 | 57 | Fungi and Viridiplantae | 0 | 446 | ||||
247 | 305 | 65 | 0 | 304 | 0 | 0 | 58 | Fungi | 0 | 425 | ||||
248 | 305 | 88 | 0 | 299 | 0 | 0 | 64 | Fungi | 0 | 155 | ||||
249 | 303 | 86 | 0 | 290 | 19 | 1 | Glutaredoxin: 19 | 80 | Fungi and Viridiplantae | 0 | 267 | |||
250 | 302 | 58 | 0 | 301 | 0 | 0 | 65 | Fungi | 0 | 411 | ||||
251 | 300 | 88 | 0 | 292 | 0 | 0 | 63 | Fungi and Viridiplantae | 0 | 291 | ||||
252 | 298 | 84 | 0 | 296 | 0 | 0 | 80 | Fungi | 0 | 628 | ||||
253 | 296 | 65 | 0 | 294 | 1 | 1 | Porin subfamily: 1 | 71 | Fungi | 0 | 372 | |||
254 | 295 | 64 | 0 | 293 | 0 | 0 | 59 | Fungi | 0 | 160 | ||||
255 | 294 | 65 | 0 | 293 | 0 | 0 | 56 | Fungi | 0 | 324 | ||||
256 | 293 | 65 | 0 | 293 | 0 | 0 | 69 | Fungi | 0 | 293 | ||||
257 | 291 | 65 | 0 | 290 | 0 | 0 | 67 | Fungi and SAR | 0 | 235 | ||||
258 | 291 | 87 | 0 | 273 | 159 | 2 | Ykl077w/Psg1 (Pma1 Stabilization in Golgi): 158 Amino acid permease:1 | 59 | Fungi | 0 | 516 | |||
259 | 291 | 65 | 0 | 290 | 0 | 0 | 54 | Universal | 0 | 393 | ||||
260 | 288 | 48 | 0 | 245 | 0 | 0 | 89 | Eukaryota | 0 | 262 | ||||
261 | 288 | 86 | 0 | 283 | 0 | 0 | 63 | Fungi | 0 | 227 | ||||
262 | 285 | 65 | 0 | 285 | 0 | 0 | 44 | Fungi | 0 | 877 | ||||
263 | 284 | 71 | 0 | 278 | 3 | 1 | AT hook motif: 3 | 63 | Fungi and SAR | 0 | 668 | |||
264 | 283 | 71 | 0 | 283 | 0 | 0 | 62 | Fungi | 0 | 245 | ||||
265 | 282 | 87 | 0 | 269 | 1 | 1 | Alba: 1 | 80 | Fungi | 0 | 209 | |||
266 | 282 | 88 | 0 | 277 | 0 | 0 | 48 | Fungi and Viridiplantae | 0 | 1,109 | ||||
267 | 281 | 88 | 0 | 275 | 0 | 0 | 72 | Fungi | 0 | 361 | ||||
268 | 281 | 89 | 0 | 281 | 0 | 0 | 80 | Fungi | 0 | 203 | ||||
269 | 280 | 89 | 0 | 272 | 2 | 2 | UbiA prenyltransferase family: 1 Tetraspanin family:1 | 70 | Fungi | 0 | 303 | |||
270 | 280 | 66 | 0 | 280 | 0 | 0 | 60 | Fungi and Viridiplantae | 0 | 468 | ||||
271 | 279 | 88 | 0 | 269 | 0 | 0 | 72 | Fungi and Viridiplantae | 0 | 360 | ||||
272 | 279 | 66 | 0 | 279 | 0 | 0 | 64 | Fungi | 0 | 652 | ||||
273 | 277 | 79 | 0 | 276 | 0 | 0 | 73 | Fungi | 0 | 213 | ||||
274 | 275 | 85 | 0 | 266 | 0 | 0 | 61 | Fungi | 0 | 370 | ||||
275 | 274 | 87 | 0 | 266 | 0 | 0 | 80 | Fungi | 0 | 467 | ||||
276 | 271 | 69 | 0 | 269 | 0 | 0 | 51 | Fungi | 0 | 410 | ||||
277 | 269 | 72 | 0 | 269 | 0 | 0 | 71 | Fungi | 0 | 331 | ||||
278 | 268 | 83 | 0 | 236 | 0 | 0 | 78 | Fungi | 0 | 402 | ||||
279 | 265 | 70 | 0 | 263 | 0 | 0 | 67 | Fungi | 0 | 158 | ||||
280 | 264 | 88 | 0 | 262 | 2 | 1 | Nematode cuticle collagen N-terminal domain: 2 | 58 | Fungi and Viridiplantae | 0 | 568 | |||
281 | 262 | 92 | 0 | 260 | 0 | 0 | 54 | Fungi and Viridiplantae | 0 | 933 | ||||
282 | 262 | 89 | 0 | 259 | 0 | 0 | 77 | Fungi | 0 | 155 | ||||
283 | 258 | 72 | 0 | 258 | 0 | 0 | 62 | Fungi | 0 | 610 | ||||
284 | 256 | 75 | 0 | 256 | 0 | 0 | 62 | Fungi | 0 | 824 | ||||
285 | 255 | 69 | 0 | 254 | 0 | 0 | 88 | Fungi | 0 | 140 | ||||
286 | 254 | 50 | 0 | 245 | 15 | 1 | F-box domain: 15 | 76 | Universal | 0 | 493 | |||
287 | 252 | 86 | 0 | 246 | 2 | 2 | Amastin surface glycoprotein: 1 PMP-22/EMP/MP20/Claudin tight junction:1 | 87 | Fungi | 0 | 216 | |||
288 | 250 | 82 | 0 | 250 | 8 | 3 | EF-hand domain pair: 8 EF hand associated:6 EF hand associated:6 | 79 | Fungi and Viridiplantae | 0 | 153 | |||
289 | 246 | 85 | 0 | 243 | 0 | 0 | 62 | Fungi | 0 | 306 | ||||
290 | 243 | 88 | 0 | 239 | 0 | 0 | 65 | Fungi | 0 | 813 | ||||
291 | 241 | 72 | 0 | 236 | 0 | 0 | 68 | Fungi and Viridiplantae | 0 | 168 | ||||
292 | 238 | 76 | 0 | 238 | 0 | 0 | 57 | Fungi and Viridiplantae | 0 | 274 | ||||
293 | 237 | 41 | 0 | 140 | 0 | 0 | 91 | Fungi | 0 | 253 | ||||
294 | 236 | 78 | 0 | 236 | 1 | 1 | Dephospho-CoA kinase: 1 | 52 | Fungi | 0 | 549 | |||
295 | 236 | 76 | 0 | 235 | 0 | 0 | 68 | Fungi | 0 | 344 | ||||
296 | 235 | 88 | 0 | 233 | 0 | 0 | 48 | Fungi | 0 | 829 | ||||
297 | 234 | 79 | 0 | 233 | 0 | 0 | 52 | Fungi and Viridiplantae | 0 | 628 | ||||
298 | 232 | 45 | 0 | 147 | 0 | 0 | 80 | Fungi and Viridiplantae | 0 | 965 | ||||
299 | 231 | 85 | 0 | 210 | 0 | 0 | 71 | Fungi | 0 | 315 | ||||
300 | 226 | 84 | 0 | 205 | 17 | 1 | Ricin-type beta-trefoil lectin domain: 17 | 83 | Fungi | 0 | 270 | |||
301 | 222 | 92 | 0 | 209 | 0 | 0 | 71 | Fungi | 0 | 297 | ||||
302 | 220 | 88 | 0 | 218 | 0 | 0 | 68 | Fungi | 0 | 557 | ||||
303 | 217 | 78 | 0 | 206 | 0 | 0 | 85 | Fungi | 0 | 205 | ||||
304 | 214 | 80 | 0 | 213 | 0 | 0 | 55 | Fungi | 0 | 1,193 | ||||
305 | 212 | 88 | 0 | 207 | 0 | 0 | 64 | Fungi and Viridiplantae | 0 | 581 | ||||
306 | 211 | 53 | 0 | 204 | 0 | 0 | 71 | Fungi and Viridiplantae | 0 | 179 | ||||
307 | 211 | 46 | 0 | 167 | 0 | 0 | 84 | Universal | 0 | 552 | ||||
308 | 210 | 68 | 0 | 197 | 0 | 0 | 88 | Fungi and Viridiplantae | 0 | 481 | ||||
309 | 205 | 60 | 0 | 201 | 9 | 1 | Nuclear pore complex subunit Nro1: 9 | 85 | Fungi and Prokaryotes | 0 | 247 | |||
310 | 204 | 84 | 0 | 204 | 0 | 0 | 74 | Fungi and SAR | 0 | 370 | ||||
311 | 203 | 71 | 0 | 193 | 0 | 0 | 93 | Fungi | 0 | 285 | ||||
312 | 201 | 63 | 0 | 152 | 0 | 0 | 70 | Fungi | 0 | 396 | ||||
313 | 199 | 87 | 0 | 199 | 0 | 0 | 44 | Fungi and Viridiplantae | 0 | 1,131 | ||||
314 | 197 | 26 | 0 | 131 | 0 | 0 | 86 | Fungi and opisthokonts | 0 | 153 | ||||
315 | 182 | 32 | 0 | 125 | 0 | 0 | 87 | Fungi | 0 | 124 | ||||
316 | 174 | 83 | 0 | 160 | 0 | 0 | 82 | Fungi | 0 | 210 | ||||
317 | 169 | 66 | 0 | 166 | 0 | 0 | 76 | Fungi and Viridiplantae | 0 | 335 | ||||
318 | 164 | 65 | 0 | 160 | 0 | 0 | 67 | Fungi and Viridiplantae | 0 | 175 | ||||
319 | 155 | 67 | 0 | 152 | 0 | 0 | 80 | Fungi and Viridiplantae | 0 | 219 | ||||
320 | 151 | 32 | 0 | 129 | 0 | 0 | 90 | Universal | 0 | 210 | ||||
321 | 151 | 68 | 0 | 143 | 0 | 0 | 52 | Fungi | 0 | 230 | ||||
322 | 150 | 66 | 0 | 146 | 0 | 0 | 75 | Fungi | 0 | 340 | ||||
323 | 150 | 69 | 0 | 144 | 0 | 0 | 78 | Fungi and Prokaryotes | 0 | 173 | ||||
324 | 149 | 65 | 0 | 143 | 0 | 0 | 85 | Fungi | 0 | 197 | ||||
325 | 147 | 55 | 0 | 143 | 0 | 0 | 71 | Fungi and Viridiplantae | 0 | 406 | ||||
326 | 144 | 69 | 0 | 142 | 0 | 0 | 82 | Fungi and Viridiplantae | 0 | 729 | ||||
327 | 144 | 72 | 0 | 142 | 0 | 0 | 67 | Fungi and Viridiplantae | 0 | 182 | ||||
328 | 143 | 69 | 0 | 138 | 0 | 0 | 69 | Fungi | 0 | 105 | ||||
329 | 142 | 77 | 0 | 127 | 0 | 0 | 73 | Fungi | 0 | 137 | ||||
330 | 141 | 40 | 0 | 128 | 1 | 1 | KH domain: 1 | 81 | Fungi | 0 | 636 | |||
331 | 140 | 46 | 0 | 139 | 0 | 0 | 77 | Eukaryota | 0 | 245 | ||||
332 | 136 | 70 | 0 | 133 | 0 | 0 | 67 | Fungi and Prokaryotes | 0 | 232 | ||||
333 | 130 | 28 | 0 | 112 | 0 | 0 | 77 | Fungi | 0 | 152 | ||||
334 | 119 | 27 | 0 | 104 | 0 | 0 | 82 | Fungi | 0 | 123 | ||||
335 | 118 | 36 | 0 | 116 | 0 | 0 | 79 | Fungi | 0 | 326 | ||||
336 | 115 | 67 | 0 | 103 | 0 | 0 | 64 | Fungi | 0 | 211 | ||||
337 | 110 | 31 | 0 | 107 | 14 | 2 | HEAT repeat: 11 HEAT repeat associated with sister chromatid cohesion:3 | 83 | Fungi | 0 | 814 | |||
338 | 106 | 76 | 0 | 106 | 0 | 0 | 56 | Fungi | 0 | 398 | ||||
339 | 102 | 25 | 0 | 102 | 0 | 0 | 88 | Fungi and opisthokonts | 0 | 169 |
Over 18 millions proteins encoded in 1282 fungal genomes from Mycocosm were clustered into families using cascaded MMseqs2 with default parameters (Steinegger et al, 2017). Our subset of 142 clusters have the following 3 properties. Each is:
An individual family member may have manual curations retrieved from MycoCosm or functional domains not shared with the rest of its family. Families as a whole may also have similarity to distant protein families in Uniprot or Protein Data Bank (PDB), as found by pairwise HMM-based HHblits searches (Steinnegger et al, 2019) against the non-redundant Uniprot20_2016 (defined by <20% sequence identity) and PDB70 (defined by <70% sequence identity) sets of protein sequences. Such distantly related proteins are presented in the list as "hints" (‘Uniprot HMM Hint’ and ‘PDB HMM Hint’ columns).