Peptidases • Heterodoassansia hygrophilae CBS 346.65 v1.0
Annotations/GenomesAcain1Cersp1Exomac1Exova1Hethyg1Jamsp1Meimi1Rhodsp1Tilalb1Tilan2Tillet1Tilwa1TotalAnnotation Description
Merops
2171692582061811661971691901562431602,312
9711139111010118186123Water nucleophile; water bound by two Asp from monomer or dimer; all endopeptidases, from eukaryote organisms, viruses or virus-like organisms
11322121212119Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on cytoplasmic side of cell membrane.
11Water nucleophile; water bound by two Asp
161019141415181612101511170Cysteine nucleophile; catalytic residues in the order Cys, His, Asn (or Asp) in sequence
22222223222225Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
23423231132329Cysteine nucleophile; catalytic residues in the order His, Glu (or Asp), Cys in sequence
11Cysteine nucleophile; catalytic residues in the order Glu, Cys, His in sequence
112Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
22332233222329Families of peptidase inhibitors not assigned to clans
11114
1111111119
243313111322
2221231313222Families of metallopeptidases not assigned to clans
88156117978799104Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Glu, His or Asp
111111118Water nucleophile; water bound by single zinc ion ligated to His, Glu (within the motif HXXE) and His
11Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HXXEH) and Glu
111111118Water nucleophile; water bound by two zinc ions ligated by Lys, Asp, Asp, Asp, Glu
64954555556463Water nucleophile; water bound by two cobalt or manganese ions ligated by Asp, Asp, His, Glu, Glu
111113898771071011112Water nucleophile; water bound by two zinc ions ligated by His (or Asp), Asp, Glu, Asp (or Glu), His
945353551156364Water nucleophile; water bound by two zinc ions ligated by His, His or Asp, Lys or Glu, His, His.
1111116Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Asp; membrane proteins with intramembrane active site.
55655454566561Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D)
11114Asparagine nucleophile; catalytic residues in the order Asp, Asn in sequence; all self-processing endopeptidases
191925202118191820182020237Threonine, serine or cysteine nucleophile at the N-terminus of mature enzyme
42533484334548Serine or cysteine nucleophile; catalytic residues in the order Cys (or Ser), His, Glu in sequence.
11Cysteine nucleophile at the N-terminus of mature enzyme; catalytic residues in the order Cys, Thr, His
1112117Serine or threonine nucleophile; N-terminal nucleophile
649956442724383Serine nucleophile; catalytic residues in the order Asp, His, Ser in sequence in family S8, but family S53 differs
916491745956645569458549802Serine nucleophile; catalytic residues in the order Ser, Asp, His in sequence
24222326124Serine nucleophile; catalytic residues in the order Ser, Lys (within the motif SXXK) in sequence
22621232231329Serine nucleophile; catalytic residues in the order Ser, Lys (or His) in sequence
112Serine nucleophile; catalytic residues in the order Ser, His, Asp in sequence
21332322231125Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane
1113Families of peptidases of unknown catalytic mechanism not assigned to clans
11111111111112
1081213109117111399122
123
1113
22144514124