Peptidases • Aspergillus fumigatus Af293 from AspGD
Annotations/GenomesAspbr1Aspcl1Aspfl1Aspfu1Aspnid1Aspor1Aspte1Aspzo1Eurhe1Neofi1TotalAnnotation Description
Merops
3992733982742914143223142443093,238
169154413998794Water nucleophile; water bound by two Asp from monomer or dimer; all endopeptidases, from eukaryote organisms, viruses or virus-like organisms
11428Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on periplasmic side of cell membrane.
7451336587379Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on cytoplasmic side of cell membrane.
33412950103435353152350Cysteine nucleophile; catalytic residues in the order Cys, His, Asn (or Asp) in sequence
333333333330Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
11112111110Cysteine nucleophile; catalytic residues in the order His, Glu (or Asp), Cys in sequence
111111118Cysteine nucleophile; catalytic residues in the order Glu, Cys, His in sequence
112Cysteine nucleophile; active peptidase is a homodimer with active site His and Glu from one monomer and Cys from the other. Catalytic residues in the order His, Glu, Cys in each monomer.
1124Cysteine nucleophile; catalytic residues in the order Cys, His, His in sequence
522243333330Water nucleophile; water bound by Gln and Glu; all endopeptidases
11Water nucleophile; water bound by Glu; all self-cleaving endopeptidases
555754566654Families of peptidase inhibitors not assigned to clans
11
1113
11
1212311112
43221221118
11
1071613714146715109Families of metallopeptidases not assigned to clans
14152413162512131217161Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Glu, His or Asp
1121211110Water nucleophile; water bound by single zinc ion ligated to His, Glu (within the motif HXXE) and His
111115Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HXXEH) and Glu
112Water nucleophile; water bound by two zinc ions ligated by Lys, Asp, Asp, Asp, Glu
977457944864Water nucleophile; water bound by two cobalt or manganese ions ligated by Asp, Asp, His, Glu, Glu
27222617402623161622235Water nucleophile; water bound by two zinc ions ligated by His (or Asp), Asp, Glu, Asp (or Glu), His
205117813151386106Water nucleophile; water bound by two zinc ions ligated by His, His or Asp, Lys or Glu, His, His.
112Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Asp; membrane proteins with intramembrane active site.
532311313325Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D)
111115Water nucleophile; water bound by single zinc ion ligated to Asp, His and His.
11Asparagine nucleophile; catalytic residues in the order Asn, Glu in sequence; all self-processing endopeptidases
34232317Serine or cysteine nucleophile; catalytic residues in the order His, Asp, Ser (or Cys) in sequence; all endopeptidases
19222320172618202022207Threonine, serine or cysteine nucleophile at the N-terminus of mature enzyme
6986494671170Serine or cysteine nucleophile; catalytic residues in the order Cys (or Ser), His, Glu in sequence.
112Cysteine nucleophile at the N-terminus of mature enzyme; catalytic residues in the order Cys, Thr, His
1112111210Serine or threonine nucleophile; N-terminal nucleophile
11Families of serine peptidases not assigned to clans
1179849696877Serine nucleophile; catalytic residues in the order Asp, His, Ser in sequence in family S8, but family S53 differs
16877152596115311612170851,062Serine nucleophile; catalytic residues in the order Ser, Asp, His in sequence
105121171051557Serine nucleophile; catalytic residues in the order Ser, Lys (within the motif SXXK) in sequence
323317224431Serine nucleophile; catalytic residues in the order Ser, Lys (or His) in sequence
212523221222Serine nucleophile; catalytic residues in the order Ser, His, Asp in sequence
1113Serine nucleophile; catalytic residues in the order Ser, Glu, His
121121122114Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane
272391327Families of peptidases of unknown catalytic mechanism not assigned to clans
111111111110
1091111819811128107
11
11
1113
2518383357485