Peptidases • Mycorrhizal Fungi

Within the framework of the JGI Mycorrhizal Genomics Initiative (MGI) project, we are sequencing a phylogenetically and ecologically diverse suite of mycorrhizal fungi (Basidiomycota and Ascomycota), which include the major clades of symbiotic species associating with trees and woody shrubs. Analyses of these genomes will provide new insights into the diversity of mechanisms for the mycorrhizal symbioses, including ericoid-, orchidoid- and ectomycorrhizal associations. A large collaborative effort led by PI of these project, Francis Martin (INRA), aims for master publication(s) of the MGI data analyses. Researchers who wish to publish analyses using data from unpublished MGI genomes are respectfully required to contact the PIs and JGI to avoid potential conflicts on data use and coordinate other publications with the MGI master paper(s).

Annotations/GenomesAcema1Amamu1Amarub1Boled5Boledp1Cananz1Cenge3CerAGIChove1ClaPMI390Coraus1Corcam1Corgl3Gaumor1_1Geocar1Gigro1Gloin1Gyrli1Hebcy2Hydru2Hyssto1Kalpfe1Kurarg1Lacaka1Lacam2Lacbi2Lacdel1Lachat1Lachen1Lacpsa1Lacpse1Lacqui1Lacsan1Lacsub1Lacviv1Lacvol1MelPMI1271_1Melbi2Melbro1Melva1Morco1Muloch1Oidma1Paxam1Paxin1Paxru2Pilcr1Pisalb1Piscro1Pismar1Pismi1Pismi_AB1_1Pisthe1Pisthe227_1Pisti1Rhice1_1Rhidi1Rhier1Rhiir2_1RhiirA1_1RhiirA4RhiirA5RhiirB3RhiirC2Rhisa1Rhitru1Rhives1Rhivi1Rhivul1Rusbre1Ruscom1Rusdis1Rusear1Ruseme1Rusoch1Rusrug1Russem1Rusvin1Sclci1Sebve1Sebvebe1Serend1Sphbr2Suiame1Suiamp1Suibov1Suibr2Suicli1Suicot1Suidec1Suidis1Suifus1Suigr1Suihi1Suilak1Suilu4Suiocc1Suipal1Suipic1Suipla1Suisu1Suisub1Suisubl1Suitom1Suivar1Terbo2Tercla1Thega1Theter1Tirniv1Trihyb1Trima3Tubae1Tubbor1Tubma1Tubme1v2Tulca1Tulcal1Wilmi1Xerba1TotalAnnotation Description
Merops
56234632943142334833445521743031232931237822549330742128627740120939053032433865564950643866570367525144430447649533065220629562237160627238823927331730924826927630623026741927333127729328528049727935442226725321322725926430131722531028629730023223134236130751232738459833533937140037628729134467128535031638735831918918527824017622527619819518435328321733941,434
3437385354301832944313034347851218016293756842303249443748525138233634272730434323646104384617212435161918387632812119111162474364372018231731353724513914256124963516062582546751537367393954354396657605550431414582953444337464,706Water nucleophile; water bound by two Asp from monomer or dimer; all endopeptidases, from eukaryote organisms, viruses or virus-like organisms
2211112212Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on periplasmic side of cell membrane.
1411113431211162421332122111112111211132131111222312322222227111121112211111111112111412112111212221211112214412442121141256Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on cytoplasmic side of cell membrane.
2992024231430222320162020232852311317181926121316291718201923261512171328351640221333101312281516181313161415273030292931302827191112161111111313206770185512132313211521151417261715161614161313181916191719151420281515242314202329171923182,460Cysteine nucleophile; catalytic residues in the order Cys, His, Asn (or Asp) in sequence
4461092316231116711264764943104991847911767345652646441063233333345443443107667171298111012121347932109107129697789761076118121392257234132121029790Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
2321426311233233114211311113122211111342141122253554444221111111111111112121242211381215331193Cysteine nucleophile; catalytic residues in the order His, Glu (or Asp), Cys in sequence
23111111311111211111111231Cysteine nucleophile; catalytic residues in the order Glu, Cys, His in sequence
111111118Cysteine nucleophile; catalytic residues in the order Cys, His, His in sequence
111112111122122222211111111111140Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
7131457533371466151311731111129230Water nucleophile; water bound by Gln and Glu; all endopeptidases
112Water nucleophile; water bound by Glu; all self-cleaving endopeptidases
4631916352357333345555343210112222213222452442537239916118813125544756552222322262222232223222222226232222222322244224333322244472Families of peptidase inhibitors not assigned to clans
11
1124
4181840
11112121111114
22
1113
11
12111112111111511121111111111112111245
112
112131111121111221111111221211111112111111122121212123173
6114221532214642253333332214322121223184262223111211122211326111424222222323223222222113221222211122432321134255
11
11
77422453122329111213413333333433323267272482223322222221131111112222222222222233222222222222222222222211111221212112278Families of metallopeptidases not assigned to clans
161322302422145312141111101512192014241515152339181729413233461447202721161713221622152427121610121391215151513141215231523212031109121312191823151416131019301744211112111217171312111212161014111311131014131410102316101717151310192414142,102Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Glu, His or Asp
1111111111111111111111111263111111143Water nucleophile; water bound by single zinc ion ligated to His, Glu (within the motif HXXE) and His
11114Water nucleophile; water bound by single zinc ion ligated to His, Asp and His
1233121111322511113111411234211112212111211111232141232322311112224122111212111112321112111112112111241111121178Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HXXEH) and Glu
11111332711113411111112111134556454134111111111244516111112126Water nucleophile; water bound by two zinc ions ligated by Lys, Asp, Asp, Asp, Glu
109911127691098139178678888588111217127710129881191011106101081181098910129810569776666118898877159777789786119781097810710118111091279810975129678757910791,037Water nucleophile; water bound by two cobalt or manganese ions ligated by Asp, Asp, His, Glu, Glu
34121221171318191014121210131310121615171813241410161717111014121513111229271632121230182118131625312018222416912201518131314141613141814810791099812171012121216191416221918171714162015172017151618161622111011121019141089121218191,830Water nucleophile; water bound by two zinc ions ligated by His (or Asp), Asp, Glu, Asp (or Glu), His
191291414812105131011122897811118205109891411148131113911101818102251218101391411181018141615966117966881814101310881014899811189997131115181220151612131417131816161414720131465911561256310105141,363Water nucleophile; water bound by two zinc ions ligated by His, His or Asp, Lys or Glu, His, His.
11112111121111111111111111111111111111211111111111111111111111111111111111111111111111111111196Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Asp; membrane proteins with intramembrane active site.
11Water nucleophile; water bound by two zinc ions ligated by Asp, Glu, His, His, Glu
22111211111121311124Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motifs HXXXD and HXH)
466656368655565345556476596678666665448437457567116559964444444445545466665765765555655555578585555655557644664466436545647Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D)
22Water nucleophile; water bound by two cobalt ions ligated by Glu, Glu, His, His, Asp
1111116Water nucleophile; water bound by single zinc ion ligated to Asp, His and His.
111111111111111111111111111111111111111140Asparagine nucleophile; catalytic residues in the order Asp, Asn in sequence; all self-processing endopeptidases
112Asparagine nucleophile; all self-processing endopeptidases
2421113117412112115424125114111111310211119116711131121211141212122121111111263Serine or cysteine nucleophile; catalytic residues in the order His, Asp, Ser (or Cys) in sequence; all endopeptidases
24202421192622231925202119231824271921372820202121232722202522202221213725243428202029202121211828241934253120181925202520262321211917212619182021202218201821212019222120222121222321251922212021192222222124232120182124182027221618212021222,625Threonine, serine or cysteine nucleophile at the N-terminus of mature enzyme
6454457858815854364755544121244254445457531185833345435454365449444464554433974324244415345664446556451255554442574343757537597Serine or cysteine nucleophile; catalytic residues in the order Cys (or Ser), His, Glu in sequence.
152213324326Cysteine nucleophile at the N-terminus of mature enzyme; catalytic residues in the order Cys, Thr, His
41111121112112115111111112138Serine or threonine nucleophile; N-terminal nucleophile
1113Families of serine peptidases not assigned to clans
351011171355143312192022151171117816121610341851010293283176127274367325815714252583483038101261054105465513212519212119172213121187106910761076691291110139871210911887810111471110141081112278