Peptidases • Zychaea mexicana RSA 1403 v1.0
Annotations/GenomesAbsrep1Bacci1Blatri1Liccor1Lichy1Mucci2Parpar1Phybl2Rhimi1_1Synrac1Umbra1Zycmex1TotalAnnotation Description
Merops
3424222513053113042652842532832723343,626
263118262524192820202224283Water nucleophile; water bound by two Asp from monomer or dimer; all endopeptidases, from eukaryote organisms, viruses or virus-like organisms
410363434443452Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on cytoplasmic side of cell membrane.
354026323535302929312434380Cysteine nucleophile; catalytic residues in the order Cys, His, Asn (or Asp) in sequence
66545657662563Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
216311223222137Cysteine nucleophile; catalytic residues in the order His, Glu (or Asp), Cys in sequence
112Cysteine nucleophile; catalytic residues in the order Glu, Cys, His in sequence
1112211112114Cysteine nucleophile; catalytic residues in the order Cys, His, His in sequence
211211211113Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
99387776766883Families of peptidase inhibitors not assigned to clans
11
111115
1113
11
132122112
88
21211111231117
35233231141432
11111111111112Families of metallopeptidases not assigned to clans
172623161623201718152218231Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Glu, His or Asp
22Water nucleophile; water bound by single zinc ion ligated to His, Glu (within the motif HXXE) and His
131128Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HXXEH) and Glu
44445443443447Water nucleophile; water bound by two zinc ions ligated by Lys, Asp, Asp, Asp, Glu
15151191113121214111112146Water nucleophile; water bound by two cobalt or manganese ions ligated by Asp, Asp, His, Glu, Glu
17167191711101511141724178Water nucleophile; water bound by two zinc ions ligated by His (or Asp), Asp, Glu, Asp (or Glu), His
1311577127968105100Water nucleophile; water bound by two zinc ions ligated by His, His or Asp, Lys or Glu, His, His.
1111121111112Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Asp; membrane proteins with intramembrane active site.
77433655632556Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D)
5322131113325Serine or cysteine nucleophile; catalytic residues in the order His, Asp, Ser (or Cys) in sequence; all endopeptidases
333518202023211717201824266Threonine, serine or cysteine nucleophile at the N-terminus of mature enzyme
44435333323239Serine or cysteine nucleophile; catalytic residues in the order Cys (or Ser), His, Glu in sequence.
1113Serine or threonine nucleophile; N-terminal nucleophile
122215141510111911111018168Serine nucleophile; catalytic residues in the order Asp, His, Ser in sequence in family S8, but family S53 differs
859650778267615546767194860Serine nucleophile; catalytic residues in the order Ser, Asp, His in sequence
11431111417Serine nucleophile; catalytic residues in the order Ser, Lys (within the motif SXXK) in sequence
47474574633458Serine nucleophile; catalytic residues in the order Ser, Lys (or His) in sequence
33Serine nucleophile; catalytic residues in the order Ser, Lys in sequence
2221313112220Serine nucleophile; catalytic residues in the order Ser, His, Asp in sequence
911176747674675Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane
2114Families of peptidases of unknown catalytic mechanism not assigned to clans
1212111111113
212622202324202624231721267
131117
11
112