Peptidases • Dichomitus squalens CBS464.89 v1.0
Annotations/GenomesAntsi1Cerun2Dicsq1Dicsqu18370_1Dicsqu463_1Dicsqu464_1Fibra1Helsul1Polar1Polbr1Pycco1Pycco1662_1Triab1_1TotalAnnotation Description
Merops
3053394073963913862793314434473673643914,846
36414447464935335259544942587Water nucleophile; water bound by two Asp from monomer or dimer; all endopeptidases, from eukaryote organisms, viruses or virus-like organisms
11Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on periplasmic side of cell membrane.
211111112222118Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on cytoplasmic side of cell membrane.
18121620191817191412141221212Cysteine nucleophile; catalytic residues in the order Cys, His, Asn (or Asp) in sequence
51067674357331076Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
12333211112222Cysteine nucleophile; catalytic residues in the order His, Glu (or Asp), Cys in sequence
133331452227Water nucleophile; water bound by Gln and Glu; all endopeptidases
1132222133322339Families of peptidase inhibitors not assigned to clans
11
112
1111111111111
363322133322538
432222333322233Families of metallopeptidases not assigned to clans
10171515161511151618161814196Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Glu, His or Asp
1111111111111Water nucleophile; water bound by single zinc ion ligated to His, Glu (within the motif HXXE) and His
111111111111113Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HXXEH) and Glu
11125Water nucleophile; water bound by two zinc ions ligated by Lys, Asp, Asp, Asp, Glu
109881095891010109115Water nucleophile; water bound by two cobalt or manganese ions ligated by Asp, Asp, His, Glu, Glu
14151312161314181616141712190Water nucleophile; water bound by two zinc ions ligated by His (or Asp), Asp, Glu, Asp (or Glu), His
1210151515151119111111119165Water nucleophile; water bound by two zinc ions ligated by His, His or Asp, Lys or Glu, His, His.
111111111111113Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Asp; membrane proteins with intramembrane active site.
11Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motifs HXXXD and HXH)
556666565666573Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D)
112Asparagine nucleophile; catalytic residues in the order Asp, Asn in sequence; all self-processing endopeptidases
22Serine or cysteine nucleophile; catalytic residues in the order His, Asp, Ser (or Cys) in sequence; all endopeptidases
23232225242418222222222222291Threonine, serine or cysteine nucleophile at the N-terminus of mature enzyme
7677643410955578Serine or cysteine nucleophile; catalytic residues in the order Cys (or Ser), His, Glu in sequence.
11Serine or threonine nucleophile; N-terminal nucleophile
22113233323315113031272633336Serine nucleophile; catalytic residues in the order Asp, His, Ser in sequence in family S8, but family S53 differs
971251361521461471051281841871471441371,835Serine nucleophile; catalytic residues in the order Ser, Asp, His in sequence
3255544811734566Serine nucleophile; catalytic residues in the order Ser, Lys (within the motif SXXK) in sequence
424444324433546Serine nucleophile; catalytic residues in the order Ser, Lys (or His) in sequence
111111111111113Serine nucleophile; catalytic residues in the order Ser, His, Asp in sequence
325554334433347Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane
1113Families of peptidases of unknown catalytic mechanism not assigned to clans
111111111111113
1614521516161382720121336258
112
1214