Peptidases • Chytridiomycota
Annotations/GenomesAnasp1Batde5Blyhe1Caecom1Caupr1Caupr_SCcombChyhya1Chylag1Chytri1Clapol1_1Enthel1Fimjon1Gaesem1Ganpr1Gervar1Glopol1Gorhay1Hompol1Hyacur1Neosp1Obemuc1Orpsp1_1PirE2_1Pirfi3Powhir1Rhihy1Spipu1Triarc1TotalAnnotation Description
Merops
331314256457152813623123553752102322073412403722631845294433304953952282213602102178,472
1103402772010273314846162710133215247152788448Water nucleophile; water bound by two Asp from monomer or dimer; all endopeptidases, from eukaryote organisms, viruses or virus-like organisms
112116Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on periplasmic side of cell membrane.
2122425511322222243122232261Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on cytoplasmic side of cell membrane.
11Water nucleophile; water bound by two Asp
1819161915627202719141615211517201731302042162020221518555Cysteine nucleophile; catalytic residues in the order Cys, His, Asn (or Asp) in sequence
1132924661443475547421101013144635186Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
25114432312222313311442258Cysteine nucleophile; catalytic residues in the order His, Glu (or Asp), Cys in sequence
111111111111111111119Cysteine nucleophile; catalytic residues in the order Glu, Cys, His in sequence
213Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
11Cysteine nucleophile; catalytic residues in the order Cys, His, His in sequence
111115Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
11Water nucleophile; water bound by Gln and Glu; all endopeptidases
1111116Water nucleophile; water bound by Glu; all self-cleaving endopeptidases
1252421766665455745424866541144168Families of peptidase inhibitors not assigned to clans
1311422213313162
11
211116
112
11
1113
11
11111233131311111312234
11112121122217
111111118
11
111161121112142112818411163Families of metallopeptidases not assigned to clans
48351551156454635141020221819492513224546116663019251115881Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Glu, His or Asp
12273413364331615122262373Water nucleophile; water bound by single zinc ion ligated to His, Glu (within the motif HXXE) and His
11Water nucleophile; water bound by single zinc ion ligated to His, Asp and His
2221212132211131112421111142Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HXXEH) and Glu
32142152423344332555543354390Water nucleophile; water bound by two zinc ions ligated by Lys, Asp, Asp, Asp, Glu
57574211799788787877108865811910208Water nucleophile; water bound by two cobalt or manganese ions ligated by Asp, Asp, His, Glu, Glu
811116942513253379916111815121815277651325129379Water nucleophile; water bound by two zinc ions ligated by His (or Asp), Asp, Glu, Asp (or Glu), His
142321118118274137542261123115955163Water nucleophile; water bound by two zinc ions ligated by His, His or Asp, Lys or Glu, His, His.
1111212111111111111111125Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Asp; membrane proteins with intramembrane active site.
11Water nucleophile; water bound by two zinc ions ligated by Asp, Glu, His, His, Glu
563543546444337674764554546129Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D)
11Water nucleophile; water bound by single zinc ion ligated to Asp, His and His.
111221111112116Asparagine nucleophile; catalytic residues in the order Asp, Asn in sequence; all self-processing endopeptidases
9212213531312852281412131118Serine or cysteine nucleophile; catalytic residues in the order His, Asp, Ser (or Cys) in sequence; all endopeptidases
1515191718930212724171717212119181632312017151719191919549Threonine, serine or cysteine nucleophile at the N-terminus of mature enzyme
15423354764535246310369133954125Serine or cysteine nucleophile; catalytic residues in the order Cys (or Ser), His, Glu in sequence.
111115Cysteine nucleophile at the N-terminus of mature enzyme; catalytic residues in the order Cys, Thr, His
111311111411311121421134Serine or threonine nucleophile; N-terminal nucleophile
11Families of serine peptidases not assigned to clans
43215202210294215108495213165423817681021358Serine nucleophile; catalytic residues in the order Asp, His, Ser in sequence in family S8, but family S53 differs
91447114425128367100106645941119618873442291258011812758499849352,260Serine nucleophile; catalytic residues in the order Ser, Asp, His in sequence
1101765816316426214912241312180Serine nucleophile; catalytic residues in the order Ser, Lys (within the motif SXXK) in sequence
6553419576576545834852235577142Serine nucleophile; catalytic residues in the order Ser, Lys (or His) in sequence
111115Serine nucleophile; catalytic residues in the order Ser, Lys in sequence
11211222311213231312211222146Serine nucleophile; catalytic residues in the order Ser, His, Asp in sequence
123Serine nucleophile; catalytic residues in the order His, Ser within the motif HXS.
1113Serine nucleophile; catalytic residues in the order Ser, Glu, His
1033102232314476755141546454544133Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane
12317Families of peptidases of unknown catalytic mechanism not assigned to clans
2111212211111141122111132
11
15241616221526292328201521171424261914331550341516311518611
11
122626212125
211217