Peptidases • Aspergillus niger CBS 513.88
Annotations/GenomesAspac1Aspbr1Aspca3Aspcl1Aspfl1Aspfo1Aspfu1Aspgl1Aspni5Aspni_DSM_1Aspnid1Aspor1Aspsy1Aspte1Asptu1Aspve1Aspwe1Aspzo1Eurhe1Neofi1Pench1TotalAnnotation Description
Merops
3583994092733983722742733792914144073223734283643142443092956,896
13161791512481341369126189879208Water nucleophile; water bound by two Asp from monomer or dimer; all endopeptidases, from eukaryote organisms, viruses or virus-like organisms
1114234117Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on periplasmic side of cell membrane.
10784510187336285103378737207Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on cytoplasmic side of cell membrane.
3133384129355035331034203533193835315233665Cysteine nucleophile; catalytic residues in the order Cys, His, Asn (or Asp) in sequence
3333333333333332333258Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
213111112111111120Cysteine nucleophile; catalytic residues in the order His, Glu (or Asp), Cys in sequence
111111111111111116Cysteine nucleophile; catalytic residues in the order Glu, Cys, His in sequence
112Cysteine nucleophile; active peptidase is a homodimer with active site His and Glu from one monomer and Cys from the other. Catalytic residues in the order His, Glu, Cys in each monomer.
111121119Cysteine nucleophile; catalytic residues in the order Cys, His, His in sequence
6562262444333623333474Water nucleophile; water bound by Gln and Glu; all endopeptidases
11Water nucleophile; water bound by Glu; all self-cleaving endopeptidases
55555577554455496665108Families of peptidase inhibitors not assigned to clans
111216
1113
11114
11
11
11121122132113211329
644324224142533211356
11
10106716913777149141013567153188Families of metallopeptidases not assigned to clans
1014181524141312151625221215191913121710315Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Glu, His or Asp
1111211121111111119Water nucleophile; water bound by single zinc ion ligated to His, Glu (within the motif HXXE) and His
111111118Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HXXEH) and Glu
112Water nucleophile; water bound by two zinc ions ligated by Lys, Asp, Asp, Asp, Glu
891177846857698764489141Water nucleophile; water bound by two cobalt or manganese ions ligated by Asp, Asp, His, Glu, Glu
2827242226251715344026382325412516162225515Water nucleophile; water bound by two zinc ions ligated by His (or Asp), Asp, Glu, Asp (or Glu), His
1120145111671014813121515168138611233Water nucleophile; water bound by two zinc ions ligated by His, His or Asp, Lys or Glu, His, His.
112Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Asp; membrane proteins with intramembrane active site.
11Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motifs HXXXD and HXH)
4543253351123523133462Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D)
1121111111112Water nucleophile; water bound by single zinc ion ligated to Asp, His and His.
11Asparagine nucleophile; catalytic residues in the order Asn, Glu in sequence; all self-processing endopeptidases
3422132244330Serine or cysteine nucleophile; catalytic residues in the order His, Asp, Ser (or Cys) in sequence; all endopeptidases
2219232223202021211726191818192020202220410Threonine, serine or cysteine nucleophile at the N-terminus of mature enzyme
5611987659496499967118148Serine or cysteine nucleophile; catalytic residues in the order Cys (or Ser), His, Glu in sequence.
112Cysteine nucleophile at the N-terminus of mature enzyme; catalytic residues in the order Cys, Thr, His
1211111221111218Serine or threonine nucleophile; N-terminal nucleophile
11Families of serine peptidases not assigned to clans
1011117911861349569499687162Serine nucleophile; catalytic residues in the order Asp, His, Ser in sequence in family S8, but family S53 differs
138168166771521495980147611531401161501411261217085922,391Serine nucleophile; catalytic residues in the order Ser, Asp, His in sequence
6106512414817610781051510126Serine nucleophile; catalytic residues in the order Ser, Lys (within the motif SXXK) in sequence
4322333321752355244568Serine nucleophile; catalytic residues in the order Ser, Lys (or His) in sequence
2221225122332232212243Serine nucleophile; catalytic residues in the order Ser, His, Asp in sequence
11112118Serine nucleophile; catalytic residues in the order Ser, Glu, His
2132111222111111221129Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane
2722339313223143Families of peptidases of unknown catalytic mechanism not assigned to clans
1111111111111111111120
91013911101116128191081010111112810218
1225
1113
1111116
325118738333338105743180