Peptidases • Lepista nuda CBS 247.69 v1.0
Annotations/GenomesLacam2Lacbi2Lepnud1Panst_KUC8834_1_1Trima3TotalAnnotation Description
Merops
3243383654652761,768
3032155829164Water nucleophile; water bound by two Asp from monomer or dimer; all endopeptidases, from eukaryote organisms, viruses or virus-like organisms
22Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on periplasmic side of cell membrane.
222129Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on cytoplasmic side of cell membrane.
1629182714104Cysteine nucleophile; catalytic residues in the order Cys, His, Asn (or Asp) in sequence
4949430Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
3111814Cysteine nucleophile; catalytic residues in the order His, Glu (or Asp), Cys in sequence
55Water nucleophile; water bound by Gln and Glu; all endopeptidases
101135332Families of peptidase inhibitors not assigned to clans
181836
11
22217
3232313
3333214Families of metallopeptidases not assigned to clans
1817411917112Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Glu, His or Asp
113319Water nucleophile; water bound by single zinc ion ligated to His, Glu (within the motif HXXE) and His
1411411Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HXXEH) and Glu
3411110Water nucleophile; water bound by two zinc ions ligated by Lys, Asp, Asp, Asp, Glu
11121510856Water nucleophile; water bound by two cobalt or manganese ions ligated by Asp, Asp, His, Glu, Glu
101620211481Water nucleophile; water bound by two zinc ions ligated by His (or Asp), Asp, Glu, Asp (or Glu), His
8912181259Water nucleophile; water bound by two zinc ions ligated by His, His or Asp, Lys or Glu, His, His.
111115Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Asp; membrane proteins with intramembrane active site.
11Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motifs HXXXD and HXH)
5956631Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D)
112Serine or cysteine nucleophile; catalytic residues in the order His, Asp, Ser (or Cys) in sequence; all endopeptidases
2123192327113Threonine, serine or cysteine nucleophile at the N-terminus of mature enzyme
121275440Serine or cysteine nucleophile; catalytic residues in the order Cys (or Ser), His, Glu in sequence.
2114Serine or threonine nucleophile; N-terminal nucleophile
10101629570Serine nucleophile; catalytic residues in the order Asp, His, Ser in sequence in family S8, but family S53 differs
787413217877539Serine nucleophile; catalytic residues in the order Ser, Asp, His in sequence
52138129Serine nucleophile; catalytic residues in the order Ser, Lys (within the motif SXXK) in sequence
3433316Serine nucleophile; catalytic residues in the order Ser, Lys (or His) in sequence
112Serine nucleophile; catalytic residues in the order Ser, Lys in sequence
111115Serine nucleophile; catalytic residues in the order Ser, His, Asp in sequence
4644422Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane
11114Families of peptidases of unknown catalytic mechanism not assigned to clans
111115
3721151220105
66