Peptidases • Phanerochaete chrysosporium RP-78 v2.2
Annotations/GenomesAntsi1Bjead1_1Cersu1Dicsq1Fompi3Gansp1Glotr1_1Lenti6_1Phaca1Phchr1Phchr2Phlbr1PosplRSB12_1Trave1Triab1_1Wolco1TotalAnnotation Description
Merops
3054023404073383803154264503544503344333913215,646
365841443948364469626547624240733Water nucleophile; water bound by two Asp from monomer or dimer; all endopeptidases, from eukaryote organisms, viruses or virus-like organisms
22114211122211124Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on cytoplasmic side of cell membrane.
181613161415201017161813152116238Cysteine nucleophile; catalytic residues in the order Cys, His, Asn (or Asp) in sequence
5157610565731764108114Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
1231115222222Cysteine nucleophile; catalytic residues in the order His, Glu (or Asp), Cys in sequence
112Cysteine nucleophile; catalytic residues in the order Cys, His, His in sequence
13681334111169Water nucleophile; water bound by Gln and Glu; all endopeptidases
1922210334515223265Families of peptidase inhibitors not assigned to clans
1113
11
11111111111111115
3433122324812543
43223233331522442Families of metallopeptidases not assigned to clans
1017915111415241592014221411220Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Glu, His or Asp
112111111111114Water nucleophile; water bound by single zinc ion ligated to His, Glu (within the motif HXXE) and His
11111113115111323Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HXXEH) and Glu
1111113211Water nucleophile; water bound by two zinc ions ligated by Lys, Asp, Asp, Asp, Glu
108987898891110999132Water nucleophile; water bound by two cobalt or manganese ions ligated by Asp, Asp, His, Glu, Glu
142013131613161514151513151217221Water nucleophile; water bound by two zinc ions ligated by His (or Asp), Asp, Glu, Asp (or Glu), His
12101115111111111110111112912168Water nucleophile; water bound by two zinc ions ligated by His, His or Asp, Lys or Glu, His, His.
111111111111113Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Asp; membrane proteins with intramembrane active site.
11114Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motifs HXXXD and HXH)
56665665666775688Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D)
11114Asparagine nucleophile; catalytic residues in the order Asp, Asn in sequence; all self-processing endopeptidases
112Serine or cysteine nucleophile; catalytic residues in the order His, Asp, Ser (or Cys) in sequence; all endopeptidases
232117222222222319222320222224324Threonine, serine or cysteine nucleophile at the N-terminus of mature enzyme
77674667666555588Serine or cysteine nucleophile; catalytic residues in the order Cys (or Ser), His, Glu in sequence.
11Serine or threonine nucleophile; N-terminal nucleophile
22524322825113917123123343320356Serine nucleophile; catalytic residues in the order Asp, His, Ser in sequence in family S8, but family S53 differs
971521361361161281121801471271601131781371052,024Serine nucleophile; catalytic residues in the order Ser, Asp, His in sequence
37256345238465164Serine nucleophile; catalytic residues in the order Ser, Lys (within the motif SXXK) in sequence
43343434223545453Serine nucleophile; catalytic residues in the order Ser, Lys (or His) in sequence
11Serine nucleophile; catalytic residues in the order Ser, Lys in sequence
12111111111111116Serine nucleophile; catalytic residues in the order Ser, His, Asp in sequence
34354434144433352Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane
111115Families of peptidases of unknown catalytic mechanism not assigned to clans
11111111111111115
162521521635141853141417133622366
11
1113
1326