Peptidases • Umbelopsis isabellina AD026 v1.0
Annotations/GenomesBlatri1Chlpad1Cokrec1Cunech1Gilper1Gonbut1Kircor1Parpar1Phaart1PnitS609_1Radspe1Rhimi_ATCC52814_1Sakvas1Spifus1Synrac1Umbisa1Umbra1Umbsp_AD052_1Zycmex1TotalAnnotation Description
Merops
2513162473182642673672653232772642322392292832742722773345,299
18232122242436192432192013192022222324425Water nucleophile; water bound by two Asp from monomer or dimer; all endopeptidases, from eukaryote organisms, viruses or virus-like organisms
343333432534334233462Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on cytoplasmic side of cell membrane.
11Water nucleophile; water bound by two Asp
26332234262836303127312827233124242434539Cysteine nucleophile; catalytic residues in the order Cys, His, Asn (or Asp) in sequence
5667646561056556222599Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
312231323211222323139Cysteine nucleophile; catalytic residues in the order His, Glu (or Asp), Cys in sequence
1113Cysteine nucleophile; catalytic residues in the order Glu, Cys, His in sequence
112211111211322123Cysteine nucleophile; catalytic residues in the order Cys, His, His in sequence
1121221111121118Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
3875669764675466668115Families of peptidase inhibitors not assigned to clans
11
11131111111
12112119
11114
121213112222121
8113123
22122211222121311129
221122534131214313445
111111111111111116Families of metallopeptidases not assigned to clans
23171714171219201617171517141515222018325Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Glu, His or Asp
2226Water nucleophile; water bound by single zinc ion ligated to His, Glu (within the motif HXXE) and His
3111212213Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HXXEH) and Glu
434343445334334333467Water nucleophile; water bound by two zinc ions ligated by Lys, Asp, Asp, Asp, Glu
111291112101212121312129121110111012213Water nucleophile; water bound by two cobalt or manganese ions ligated by Asp, Asp, His, Glu, Glu
7148138131510201310106111416171624245Water nucleophile; water bound by two zinc ions ligated by His (or Asp), Asp, Glu, Asp (or Glu), His
595978876854568910125136Water nucleophile; water bound by two zinc ions ligated by His, His or Asp, Lys or Glu, His, His.
1121113111111111120Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Asp; membrane proteins with intramembrane active site.
444552755446453423581Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D)
1113Asparagine nucleophile; catalytic residues in the order Asp, Asn in sequence; all self-processing endopeptidases
252431332121111433345Serine or cysteine nucleophile; catalytic residues in the order His, Asp, Ser (or Cys) in sequence; all endopeptidases
18302121162236212120191920192019181924403Threonine, serine or cysteine nucleophile at the N-terminus of mature enzyme
4247321033422422233264Serine or cysteine nucleophile; catalytic residues in the order Cys (or Ser), His, Glu in sequence.
11114Serine or threonine nucleophile; N-terminal nucleophile
151991511101211191515815911710818237Serine nucleophile; catalytic residues in the order Asp, His, Ser in sequence in family S8, but family S53 differs
507560845174926186565948565076787173941,294Serine nucleophile; catalytic residues in the order Ser, Asp, His in sequence
1123115111112425Serine nucleophile; catalytic residues in the order Ser, Lys (within the motif SXXK) in sequence
433544574445433333475Serine nucleophile; catalytic residues in the order Ser, Lys (or His) in sequence
211111113112111223228Serine nucleophile; catalytic residues in the order Ser, His, Asp in sequence
11Serine nucleophile; catalytic residues in the order His, Ser within the motif HXS.
16510688496548675456113Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane
3111111110Families of peptidases of unknown catalytic mechanism not assigned to clans
121111311111111119
22201825201524201923271717202317171421379
221218
112