Peptidases • Chaetomium megalocarpum MPI-CAGE-AT-0009 v1.0
Annotations/GenomesAchstr1Chafi1Chagl_1Chame1Corsim1Myche1Mychet1Spoth2Thian1Thiap1Thiar1Thihy1Thite2TotalAnnotation Description
Merops
2642982663162652222302431902562692312563,306
20191520171616171718161426231Water nucleophile; water bound by two Asp from monomer or dimer; all endopeptidases, from eukaryote organisms, viruses or virus-like organisms
314Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on periplasmic side of cell membrane.
212211112232323Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on cytoplasmic side of cell membrane.
14151417151717201616161515207Cysteine nucleophile; catalytic residues in the order Cys, His, Asn (or Asp) in sequence
222223233533335Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
11111111111112Cysteine nucleophile; catalytic residues in the order His, Glu (or Asp), Cys in sequence
111211111111114Cysteine nucleophile; catalytic residues in the order Glu, Cys, His in sequence
1214Cysteine nucleophile; catalytic residues in the order Cys, His, His in sequence
111111111110Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
664543322534451Water nucleophile; water bound by Gln and Glu; all endopeptidases
434344434435550Families of peptidase inhibitors not assigned to clans
221222222222225
421241111554435
333321111323127Families of metallopeptidases not assigned to clans
11891011666101010129118Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Glu, His or Asp
333433332333238Water nucleophile; water bound by single zinc ion ligated to His, Glu (within the motif HXXE) and His
2321111242120Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HXXEH) and Glu
876788888878899Water nucleophile; water bound by two cobalt or manganese ions ligated by Asp, Asp, His, Glu, Glu
13151617131516151215161211186Water nucleophile; water bound by two zinc ions ligated by His (or Asp), Asp, Glu, Asp (or Glu), His
91068879897979106Water nucleophile; water bound by two zinc ions ligated by His, His or Asp, Lys or Glu, His, His.
11Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Asp; membrane proteins with intramembrane active site.
323323443333440Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D)
11114Serine or cysteine nucleophile; catalytic residues in the order His, Asp, Ser (or Cys) in sequence; all endopeptidases
24202123192120202221211920271Threonine, serine or cysteine nucleophile at the N-terminus of mature enzyme
657553342746360Serine or cysteine nucleophile; catalytic residues in the order Cys (or Ser), His, Glu in sequence.
11Cysteine nucleophile at the N-terminus of mature enzyme; catalytic residues in the order Cys, Thr, His
11Serine or threonine nucleophile; N-terminal nucleophile
1413121514991161214109148Serine nucleophile; catalytic residues in the order Asp, His, Ser in sequence in family S8, but family S53 differs
8412310712510272768048739063861,129Serine nucleophile; catalytic residues in the order Ser, Asp, His in sequence
711595557492776Serine nucleophile; catalytic residues in the order Ser, Lys (within the motif SXXK) in sequence
233333333333338Serine nucleophile; catalytic residues in the order Ser, Lys (or His) in sequence
111111111111113Serine nucleophile; catalytic residues in the order Ser, His, Asp in sequence
232323331223231Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane
111111111111113
1312141812101313915131714173
111133212