Peptidases • Helotiales
Annotations/GenomesAcema1Amyenc1Ascsa1Atrpi1Bissp1Botci1Cadsp1Calmar1Chalo1Glalo1Greab1Hyafin1Hymvar1Lacsu1Lepor2Leptod1Lorju1Lorma1Mabrmo1Marbr1MelPMI1271_1Melbi2Melva1Phisc1Rhesp1Rhier1Rutfi1Sclsc1TotalAnnotation Description
Merops
56231429447752532472527767236932647043638967465741241426324647649565264850341934227712,638
34171540191831185020172529213433353212102727434127321612735Water nucleophile; water bound by two Asp from monomer or dimer; all endopeptidases, from eukaryote organisms, viruses or virus-like organisms
1111116Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on periplasmic side of cell membrane.
14459114178165911681917910681113131715756283Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on cytoplasmic side of cell membrane.
29271925292137202925242828263934212422232835402631302418762Cysteine nucleophile; catalytic residues in the order Cys, His, Asn (or Asp) in sequence
423432325247324444334554352298Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
21112112312223453112212231152Cysteine nucleophile; catalytic residues in the order His, Glu (or Asp), Cys in sequence
222513211222112111133412147Cysteine nucleophile; catalytic residues in the order Glu, Cys, His in sequence
221111210Cysteine nucleophile; catalytic residues in the order Cys, His, His in sequence
1111111111111111111111123Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
72433411843426355322461581752129Water nucleophile; water bound by Gln and Glu; all endopeptidases
112Water nucleophile; water bound by Glu; all self-cleaving endopeptidases
4444455444554345553445454445120Families of peptidase inhibitors not assigned to clans
11114
111115
11
1214
1221121212121122222212212141
6236447273323454543323855233111
11114
74571241038346351110662267777333161Families of metallopeptidases not assigned to clans
16179173493315232110232014312815141916161722212212118513Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Glu, His or Asp
121253221221222211221111212350Water nucleophile; water bound by single zinc ion ligated to His, Glu (within the motif HXXE) and His
112224112113111111122221121243Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HXXEH) and Glu
108891181181099109810109974910101210988253Water nucleophile; water bound by two cobalt or manganese ions ligated by Asp, Asp, His, Glu, Glu
34221633402041223826242726244140272620182927324135202317789Water nucleophile; water bound by two zinc ions ligated by His (or Asp), Asp, Glu, Asp (or Glu), His
191012141682592314814172020231011109181822261711118423Water nucleophile; water bound by two zinc ions ligated by His, His or Asp, Lys or Glu, His, His.
11114Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motifs HXXXD and HXH)
4444344444444443443344444444108Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D)
11112111111111111119Water nucleophile; water bound by single zinc ion ligated to Asp, His and His.
11Asparagine nucleophile; catalytic residues in the order Asp, Asn in sequence; all self-processing endopeptidases
231433724214233522235443122281Serine or cysteine nucleophile; catalytic residues in the order His, Asp, Ser (or Cys) in sequence; all endopeptidases
24232124272227272724232422262625262522212524282624252025683Threonine, serine or cysteine nucleophile at the N-terminus of mature enzyme
653476135116266610136323751168444172Serine or cysteine nucleophile; catalytic residues in the order Cys (or Ser), His, Glu in sequence.
11Cysteine nucleophile at the N-terminus of mature enzyme; catalytic residues in the order Cys, Thr, His
42222111111111111211211133Serine or threonine nucleophile; N-terminal nucleophile
111115Families of serine peptidases not assigned to clans
35121726231240153515182316214242222613122525343433251412667Serine nucleophile; catalytic residues in the order Asp, His, Ser in sequence in family S8, but family S53 differs
2381081101812041313157629014411918419113930028314715778691821842862951981601441005,013Serine nucleophile; catalytic residues in the order Ser, Asp, His in sequence
1835122163052175169827261592217221923131394367Serine nucleophile; catalytic residues in the order Ser, Lys (within the motif SXXK) in sequence
333343333333333333322333333282Serine nucleophile; catalytic residues in the order Ser, Lys (or His) in sequence
11Serine nucleophile; catalytic residues in the order Ser, Lys in sequence
211331112122221111112211321143Serine nucleophile; catalytic residues in the order Ser, His, Asp in sequence
1112211110Serine nucleophile; catalytic residues in the order Ser, Glu, His
632431325326223334344652233392Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane
121111112111111219Families of peptidases of unknown catalytic mechanism not assigned to clans
111111111111111111111111111128
18171519201230111413131812141317131412112623151515171217446
2112111111121117
1124
5144146133245331344632173