Peptidases • Exophiala alcalophila ATCC 48519 v1.0
Annotations/GenomesArtbe1Aspac1Aspbr1Aspca3Aspcam1Aspcl1Aspfl1Aspfo1Aspfu1Aspfu_A1163_1Aspgl1Aspka1_1Aspni7Aspni_DSM_1Aspni_NRRL3_1Aspni_bvT_1Aspnid1Aspnov1Aspoch1Aspor1Aspph1Aspste1Aspsy1Aspte1Asptu1Aspve1Aspwe1Aspzo1Cocim1Eurhe1Exoalc1Exoalc1_J33Gymau1Gymci1_1Hisca1Micca1Monpu1Monru1Neofi1Parbr1Penac1Penbi1Penbr2PenbrAgRF18_1Penca1Pench1PenchWisc1_1Pendi1Penex1Penfe1Pengl1Penja1Penla1Penox1Penra1Penth1Phach1Talma1_2Talst1_2Theau1Triru1Triver1Uncre1TotalAnnotation Description
Merops
22335839940926627339837227426827335938837940438229132222941437537140732237342836431422024438237722421917424424326230913750544533134138129531722537039341435929625632731823334636421423922719820,064
91316177915124481115131515477131513691261895811910948897322168109920911111211711101312382410995689Water nucleophile; water bound by two Asp from monomer or dimer; all endopeptidases, from eukaryote organisms, viruses or virus-like organisms
21111412234221121211111211212249Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on periplasmic side of cell membrane.
310784451012888797332967528510337847111023214332177876794981011647731087224469Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on cytoplasmic side of cell membrane.
2231333824412935505135373433373510511934334020353319383520312526252518223334522145413739403335283435413936333234223031272623172,022Cysteine nucleophile; catalytic residues in the order Cys, His, Asn (or Asp) in sequence
333333333333334333433333332323332222333253332233332523332463332186Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
213111111111112121111311121122111111111111111121160Cysteine nucleophile; catalytic residues in the order His, Glu (or Asp), Cys in sequence
1111111111111111111111111121111111111112111111111111155Cysteine nucleophile; catalytic residues in the order Glu, Cys, His in sequence
1113Cysteine nucleophile; active peptidase is a homodimer with active site His and Glu from one monomer and Cys from the other. Catalytic residues in the order His, Glu, Cys in each monomer.
11111112111111111111122Cysteine nucleophile; catalytic residues in the order Cys, His, His in sequence
65622262246545542335233623331223106443433366542333982203Water nucleophile; water bound by Gln and Glu; all endopeptidases
112Water nucleophile; water bound by Glu; all self-cleaving endopeptidases
355575557775555556545545549646556455556256554544455555543545433310Families of peptidase inhibitors not assigned to clans
111121119
1111111111111
2111111112111111119
11
111115
21111118
11112112221111131112211322111111222122453233213144112296
644132422244444221514253321166121231172222332132211324721157
112
4101061171691313777777718814720914101356273226162315895710333785758623533442441Families of metallopeptidases not assigned to clans
141014181315241413131214141515141615112515122212151919131512131213129161071751215119141010813101410813111111121111151514835Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Glu, His or Asp
211111211111111121211111121121121111111111111111111211123371Water nucleophile; water bound by single zinc ion ligated to His, Glu (within the motif HXXE) and His
111111111111111211111111211130Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HXXEH) and Glu
11111117Water nucleophile; water bound by two zinc ions ligated by Lys, Asp, Asp, Asp, Glu
789111077844698810756378769876474776657778510118710910887778591181076777462Water nucleophile; water bound by two cobalt or manganese ions ligated by Asp, Asp, His, Glu, Glu
10282724172226251716152226342830402519262930382325412516121621191513101219212272532303130252819333029223219292317131512108111,414Water nucleophile; water bound by two zinc ions ligated by His (or Asp), Asp, Glu, Asp (or Glu), His
711201495111676101517141615885131514121515168136829299756101365181010131211116151711137610112011118776719Water nucleophile; water bound by two zinc ions ligated by His, His or Asp, Lys or Glu, His, His.
1113Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Asp; membrane proteins with intramembrane active site.
11Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motifs HXXXD and HXH)
345433253435555514215323523133333342333335445432454342333332334211Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D)
11211111111111111111111111111111134Water nucleophile; water bound by single zinc ion ligated to Asp, His and His.
11Asparagine nucleophile; catalytic residues in the order Asn, Glu in sequence; all self-processing endopeptidases
213422211432244221243121212212311111122179Serine or cysteine nucleophile; catalytic residues in the order His, Asp, Ser (or Cys) in sequence; all endopeptidases
2122192321222320201921202021202017221626192019181819202019202828192021212020221919201819232022181821192121181922162125222321171,286Threonine, serine or cysteine nucleophile at the N-terminus of mature enzyme
156116987675689994729986499963734334357112131066988513911108811928103324425Serine or cysteine nucleophile; catalytic residues in the order Cys (or Ser), His, Glu in sequence.
111115Cysteine nucleophile at the N-terminus of mature enzyme; catalytic residues in the order Cys, Thr, His
1121111111122111111111122111111111222221151Serine or threonine nucleophile; N-terminal nucleophile
112Families of serine peptidases not assigned to clans
1610111157911876101213131247491365694991963364617998513778976577975777711145171821552Serine nucleophile; catalytic residues in the order Asp, His, Ser in sequence in family S8, but family S53 differs
68138168166747715214959578014816014716415561946815315313114011615014112612161701711706567507165748533218193109110133929567132160174128967610710269110129586867496,940Serine nucleophile; catalytic residues in the order Ser, Asp, His in sequence
56106105124114410811916277106107810551131364398953179151614109411891312691337133656482Serine nucleophile; catalytic residues in the order Ser, Lys (within the motif SXXK) in sequence
3432523333323222114724523552542223223244445555253433353332221193Serine nucleophile; catalytic residues in the order Ser, Lys (or His) in sequence
11Serine nucleophile; catalytic residues in the order Ser, Lys in sequence
222221225412222222232232232221222223222222222222222322222321222133Serine nucleophile; catalytic residues in the order Ser, His, Asp in sequence
11112111111111116Serine nucleophile; catalytic residues in the order Ser, Glu, His
12132211112212212211111111122233221212123222111222122221122211100Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane
227222233223924313223112221111214323290Families of peptidases of unknown catalytic mechanism not assigned to clans
11111111111111111111111111111111111111111111111111111111112111164
11
59101399111011916109121010813919812108101011117129108871091287121615151510138149121310811101011139778655
1225
11111111112111111119
11
111111111211111141123
4326511818738519373333810573233133341433343233106322512115541334