Peptidases • Kickxellomycotina
Annotations/GenomesCoemoj1Coere1Coespi1DimcrSC1Kicala1Linpe1Marpt1Rambr1SmicuMNP_2SmiculW2_1Smimuc2Zancul2TotalAnnotation Description
Merops
2062042232311942722553693282812202473,030
646344612572564Water nucleophile; water bound by two Asp from monomer or dimer; all endopeptidases, from eukaryote organisms, viruses or virus-like organisms
13116Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on periplasmic side of cell membrane.
11111311221116Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on cytoplasmic side of cell membrane.
212020211629162224181315235Cysteine nucleophile; catalytic residues in the order Cys, His, Asn (or Asp) in sequence
34443358544855Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
222332531124Cysteine nucleophile; catalytic residues in the order His, Glu (or Asp), Cys in sequence
11111112110Cysteine nucleophile; catalytic residues in the order Glu, Cys, His in sequence
11Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
224Cysteine nucleophile; catalytic residues in the order Cys, His, His in sequence
123Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
11Water nucleophile; water bound by Glu; all self-cleaving endopeptidases
44553533474451Families of peptidase inhibitors not assigned to clans
11
213
11136
11221511235226
11111111210Families of metallopeptidases not assigned to clans
22182223142928191211611215Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Glu, His or Asp
1515Water nucleophile; water bound by single zinc ion ligated to His, Glu (within the motif HXXE) and His
24323336532743Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HXXEH) and Glu
33433554973554Water nucleophile; water bound by two zinc ions ligated by Lys, Asp, Asp, Asp, Glu
988878791197899Water nucleophile; water bound by two cobalt or manganese ions ligated by Asp, Asp, His, Glu, Glu
81010111217122224262217191Water nucleophile; water bound by two zinc ions ligated by His (or Asp), Asp, Glu, Asp (or Glu), His
6565476743356Water nucleophile; water bound by two zinc ions ligated by His, His or Asp, Lys or Glu, His, His.
111115Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Asp; membrane proteins with intramembrane active site.
1113Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motifs HXXXD and HXH)
3335544632341Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D)
11Asparagine nucleophile; catalytic residues in the order Asp, Asn in sequence; all self-processing endopeptidases
181418101923253738383661337Serine or cysteine nucleophile; catalytic residues in the order His, Asp, Ser (or Cys) in sequence; all endopeptidases
221820212221212042282119275Threonine, serine or cysteine nucleophile at the N-terminus of mature enzyme
4452554811140Serine or cysteine nucleophile; catalytic residues in the order Cys (or Ser), His, Glu in sequence.
11Cysteine nucleophile at the N-terminus of mature enzyme; catalytic residues in the order Cys, Thr, His
21112119Serine or threonine nucleophile; N-terminal nucleophile
342201444318181517149Serine nucleophile; catalytic residues in the order Asp, His, Ser in sequence in family S8, but family S53 differs
384949414361666271564742625Serine nucleophile; catalytic residues in the order Ser, Asp, His in sequence
1818Serine nucleophile; catalytic residues in the order Ser, Lys (within the motif SXXK) in sequence
553433679105464Serine nucleophile; catalytic residues in the order Ser, Lys (or His) in sequence
213Serine nucleophile; catalytic residues in the order Ser, Lys in sequence
1122211111114Serine nucleophile; catalytic residues in the order Ser, His, Asp in sequence
112Serine nucleophile; catalytic residues in the order His, Ser within the motif HXS.
3136232422230Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane
4116Families of peptidases of unknown catalytic mechanism not assigned to clans
11111111212114
131417171215151624211012186
32117
1113
14128