Peptidases • Chytridiomycetes
Annotations/GenomesBatde5Blyhe1Caupr1Caupr_SCcombChyhya1Chylag1Chytri1Clapol1_1Enthel1Fimjon1Gaesem1Gervar1Glopol1Gorhay1Hompol1Obemuc1Powhir1Rhihy1Spipu1Triarc1TotalAnnotation Description
Merops
314256152813623123553752102322072403722631843302213602102175,253
1034077201027331484162710131552788402Water nucleophile; water bound by two Asp from monomer or dimer; all endopeptidases, from eukaryote organisms, viruses or virus-like organisms
11114Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on periplasmic side of cell membrane.
12425511322223232244Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on cytoplasmic side of cell membrane.
191615627202719141615151720172020221518358Cysteine nucleophile; catalytic residues in the order Cys, His, Asn (or Asp) in sequence
32246614434554710463597Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
25144323122233442249Cysteine nucleophile; catalytic residues in the order His, Glu (or Asp), Cys in sequence
111111111111113Cysteine nucleophile; catalytic residues in the order Glu, Cys, His in sequence
1113Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
11Water nucleophile; water bound by Gln and Glu; all endopeptidases
1111116Water nucleophile; water bound by Glu; all self-cleaving endopeptidases
522176666545745841144102Families of peptidase inhibitors not assigned to clans
22
11
211116
112
11
112
1112331313111312230
122229
11114
1111211121211111120Families of metallopeptidases not assigned to clans
351515645463514102022194925134619251115485Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Glu, His or Asp
12273413343315262355Water nucleophile; water bound by single zinc ion ligated to His, Glu (within the motif HXXE) and His
22212132211312111129Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HXXEH) and Glu
212152423343325354357Water nucleophile; water bound by two zinc ions ligated by Lys, Asp, Asp, Asp, Glu
75421179978887878811910153Water nucleophile; water bound by two cobalt or manganese ions ligated by Asp, Asp, His, Glu, Glu
1111942513253379911181512271325129298Water nucleophile; water bound by two zinc ions ligated by His (or Asp), Asp, Glu, Asp (or Glu), His
42211181182747542125955114Water nucleophile; water bound by two zinc ions ligated by His, His or Asp, Lys or Glu, His, His.
112121111111111118Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Asp; membrane proteins with intramembrane active site.
634354644437676454691Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D)
11122111112115Asparagine nucleophile; catalytic residues in the order Asp, Asn in sequence; all self-processing endopeptidases
9122135312851213168Serine or cysteine nucleophile; catalytic residues in the order His, Asp, Ser (or Cys) in sequence; all endopeptidases
151918930212724171717211918162019191919384Threonine, serine or cysteine nucleophile at the N-terminus of mature enzyme
5433547645324636395491Serine or cysteine nucleophile; catalytic residues in the order Cys (or Ser), His, Glu in sequence.
111115Cysteine nucleophile at the N-terminus of mature enzyme; catalytic residues in the order Cys, Thr, His
11311111111421121Serine or threonine nucleophile; N-terminal nucleophile
215221029421510895215681021175Serine nucleophile; catalytic residues in the order Asp, His, Ser in sequence in family S8, but family S53 differs
4471251283671001066459416188734480499849351,249Serine nucleophile; catalytic residues in the order Ser, Asp, His in sequence
1107658163426211241312112Serine nucleophile; catalytic residues in the order Ser, Lys (within the motif SXXK) in sequence
55419576576458355577109Serine nucleophile; catalytic residues in the order Ser, Lys (or His) in sequence
111115Serine nucleophile; catalytic residues in the order Ser, Lys in sequence
1212223112123132222136Serine nucleophile; catalytic residues in the order Ser, His, Asp in sequence
11Serine nucleophile; catalytic residues in the order His, Ser within the motif HXS.
112Serine nucleophile; catalytic residues in the order Ser, Glu, His
3322323144775514454473Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane
11Families of peptidases of unknown catalytic mechanism not assigned to clans
11212211111111118
11
2416221526292328201521142426191516311518417
1262112
112