Peptidases • Pilaira anomala RSA1997 v1.0
Annotations/GenomesBacci1Blatri1Kircor1Mucci2Mycafr1Parpar1Phybl2Pilano1Radspe1Rhich1Rhimi1_1Rhior3Thaele1Zyghet1TotalAnnotation Description
Merops
4222513673042332652842612643762532902943024,166
3118362416192819193520332331352Water nucleophile; water bound by two Asp from monomer or dimer; all endopeptidases, from eukaryote organisms, viruses or virus-like organisms
11Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on periplasmic side of cell membrane.
10344334435444459Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on cytoplasmic side of cell membrane.
4026363523302930314529283431447Cysteine nucleophile; catalytic residues in the order Cys, His, Asn (or Asp) in sequence
6566657558646580Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
1633222341324247Cysteine nucleophile; catalytic residues in the order His, Glu (or Asp), Cys in sequence
1111111111111Cysteine nucleophile; catalytic residues in the order Cys, His, His in sequence
2121112212122222Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
9397376761271377103Families of peptidase inhibitors not assigned to clans
11
111121119
1111116
112
88
121111122221118
5252231331122436
11111111211113Families of metallopeptidases not assigned to clans
2623192315201720172818182624294Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Glu, His or Asp
3114110Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HXXEH) and Glu
4444443438444660Water nucleophile; water bound by two zinc ions ligated by Lys, Asp, Asp, Asp, Glu
1511121312121212121614131212178Water nucleophile; water bound by two cobalt or manganese ions ligated by Asp, Asp, His, Glu, Glu
16715119101510101411161012166Water nucleophile; water bound by two zinc ions ligated by His (or Asp), Asp, Glu, Asp (or Glu), His
115812779755647699Water nucleophile; water bound by two zinc ions ligated by His, His or Asp, Lys or Glu, His, His.
1132111112112220Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Asp; membrane proteins with intramembrane active site.
74764555410666580Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D)
11Asparagine nucleophile; catalytic residues in the order Asp, Asn in sequence; all self-processing endopeptidases
3231231222112126Serine or cysteine nucleophile; catalytic residues in the order His, Asp, Ser (or Cys) in sequence; all endopeptidases
3518362319211719193117322025332Threonine, serine or cysteine nucleophile at the N-terminus of mature enzyme
44103333425334455Serine or cysteine nucleophile; catalytic residues in the order Cys (or Ser), His, Glu in sequence.
1111116Serine or threonine nucleophile; N-terminal nucleophile
22151210811197151511181114188Serine nucleophile; catalytic residues in the order Asp, His, Ser in sequence in family S8, but family S53 differs
9650926749615557597046536769891Serine nucleophile; catalytic residues in the order Ser, Asp, His in sequence
1111112121113Serine nucleophile; catalytic residues in the order Ser, Lys (within the motif SXXK) in sequence
7455574747627878Serine nucleophile; catalytic residues in the order Ser, Lys (or His) in sequence
314Serine nucleophile; catalytic residues in the order Ser, Lys in sequence
2213213111111121Serine nucleophile; catalytic residues in the order Ser, His, Asp in sequence
11187647559645583Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane
12115Families of peptidases of unknown catalytic mechanism not assigned to clans
213111112111117
2622242425202618272424232015318
11
1113
11
11