Peptidases • Lyophyllum atratum DOB2229 v1.0
Annotations/GenomesAgrped1Cligib1Copang1Copmar1Copmic2Corgl3Crafun1Galma1Gymch1Gymjun1Hebcy2Hypsu1Lacbi2Lyoat1Panpap1Panst_LUM_1_1Phoaln1Phocon1Phohig1Trima3TotalAnnotation Description
Merops
4544504853643903123353883863462863793383443994793833584192767,571
4258222515343027502916383226153919392629611Water nucleophile; water bound by two Asp from monomer or dimer; all endopeptidases, from eukaryote organisms, viruses or virus-like organisms
1124Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on periplasmic side of cell membrane.
2111312111122111111227Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on cytoplasmic side of cell membrane.
112Water nucleophile; water bound by two Asp
2119221621201520201517172917122620181814377Cysteine nucleophile; catalytic residues in the order Cys, His, Asn (or Asp) in sequence
11101110137610710699547106124167Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
2631131131121111312843Cysteine nucleophile; catalytic residues in the order His, Glu (or Asp), Cys in sequence
112112171320Water nucleophile; water bound by Gln and Glu; all endopeptidases
3177683393555114353443111Families of peptidase inhibitors not assigned to clans
82118130
11
112
1112322212121122
9411574534456251036673109
2273123222123433223251Families of metallopeptidases not assigned to clans
4637445835103328201524241739441932222617590Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Glu, His or Asp
1121111111111162111127Water nucleophile; water bound by single zinc ion ligated to His, Glu (within the motif HXXE) and His
121111111114211112428Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HXXEH) and Glu
12201131111114111111145Water nucleophile; water bound by two zinc ions ligated by Lys, Asp, Asp, Asp, Glu
101113899911910891210129910158201Water nucleophile; water bound by two cobalt or manganese ions ligated by Asp, Asp, His, Glu, Glu
2018221717101915131215171614202021141614330Water nucleophile; water bound by two zinc ions ligated by His (or Asp), Asp, Glu, Asp (or Glu), His
1115131211129121010111291010161191212227Water nucleophile; water bound by two zinc ions ligated by His, His or Asp, Lys or Glu, His, His.
1121121111111111111122Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Asp; membrane proteins with intramembrane active site.
113111210Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motifs HXXXD and HXH)
55657556565596586566116Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D)
11111117Asparagine nucleophile; catalytic residues in the order Asp, Asn in sequence; all self-processing endopeptidases
11111112110Serine or cysteine nucleophile; catalytic residues in the order His, Asp, Ser (or Cys) in sequence; all endopeptidases
2226252025191922242121202321202623192527448Threonine, serine or cysteine nucleophile at the N-terminus of mature enzyme
1822889871068712126136712164199Serine or cysteine nucleophile; catalytic residues in the order Cys (or Ser), His, Glu in sequence.
11Cysteine nucleophile at the N-terminus of mature enzyme; catalytic residues in the order Cys, Thr, His
111115Serine or threonine nucleophile; N-terminal nucleophile
151014202015172214131620101025361417205333Serine nucleophile; catalytic residues in the order Asp, His, Ser in sequence in family S8, but family S53 differs
1651421751121441041111421441389114174122155205155133155772,685Serine nucleophile; catalytic residues in the order Ser, Asp, His in sequence
102012784711121268210128712151184Serine nucleophile; catalytic residues in the order Ser, Lys (within the motif SXXK) in sequence
3333433433434433433366Serine nucleophile; catalytic residues in the order Ser, Lys (or His) in sequence
22116Serine nucleophile; catalytic residues in the order Ser, Lys in sequence
1111111111111111111120Serine nucleophile; catalytic residues in the order Ser, His, Asp in sequence
4434344443446445433478Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane
112Families of peptidases of unknown catalytic mechanism not assigned to clans
1111111111111111111120
2120121315241418221813132115131113111820325
213
66