Peptidases • Coprinopsis sclerotiger v1.0
Annotations/GenomesAmath1Copci1Copci_AmutBmut1Copmic2Copscl1Guyne1Marfi1Panst_KUC8834_1_1PleosPC9_1TotalAnnotation Description
Merops
3182872923902883584554653523,205
191120151228255823211Water nucleophile; water bound by two Asp from monomer or dimer; all endopeptidases, from eukaryote organisms, viruses or virus-like organisms
112Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on periplasmic side of cell membrane.
31131312Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on cytoplasmic side of cell membrane.
55111Water nucleophile; water bound by two Asp
141514211421242721171Cysteine nucleophile; catalytic residues in the order Cys, His, Asn (or Asp) in sequence
3561352069875Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
11121118Cysteine nucleophile; catalytic residues in the order His, Glu (or Asp), Cys in sequence
112Cysteine nucleophile; catalytic residues in the order Glu, Cys, His in sequence
55Water nucleophile; water bound by Gln and Glu; all endopeptidases
976853105255Families of peptidase inhibitors not assigned to clans
11
1122111312
55576652647
33312333223Families of metallopeptidases not assigned to clans
363029352816401931264Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Glu, His or Asp
11111139Water nucleophile; water bound by single zinc ion ligated to His, Glu (within the motif HXXE) and His
11111121110Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HXXEH) and Glu
11113121112Water nucleophile; water bound by two zinc ions ligated by Lys, Asp, Asp, Asp, Glu
978991011101184Water nucleophile; water bound by two cobalt or manganese ions ligated by Asp, Asp, His, Glu, Glu
222221171913252118178Water nucleophile; water bound by two zinc ions ligated by His (or Asp), Asp, Glu, Asp (or Glu), His
10871181515189101Water nucleophile; water bound by two zinc ions ligated by His, His or Asp, Lys or Glu, His, His.
111115Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Asp; membrane proteins with intramembrane active site.
113117Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motifs HXXXD and HXH)
67575766655Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D)
112Asparagine nucleophile; catalytic residues in the order Asp, Asn in sequence; all self-processing endopeptidases
111115Serine or cysteine nucleophile; catalytic residues in the order His, Asp, Ser (or Cys) in sequence; all endopeptidases
201919251921262320192Threonine, serine or cysteine nucleophile at the N-terminus of mature enzyme
68797675661Serine or cysteine nucleophile; catalytic residues in the order Cys (or Ser), His, Glu in sequence.
11Serine or threonine nucleophile; N-terminal nucleophile
148920317112912141Serine nucleophile; catalytic residues in the order Asp, His, Ser in sequence in family S8, but family S53 differs
10199100144851502021781301,189Serine nucleophile; catalytic residues in the order Ser, Asp, His in sequence
132283458348Serine nucleophile; catalytic residues in the order Ser, Lys (within the motif SXXK) in sequence
32343333327Serine nucleophile; catalytic residues in the order Ser, Lys (or His) in sequence
11Serine nucleophile; catalytic residues in the order Ser, Lys in sequence
1111111119Serine nucleophile; catalytic residues in the order Ser, His, Asp in sequence
11Serine nucleophile; catalytic residues in the order Ser, Glu, His
43334434432Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane
112Families of peptidases of unknown catalytic mechanism not assigned to clans
1111111119
13109151011131224117
112
66