Peptidases • Aspergillus wentii v1.0
Annotations/GenomesAspac1Aspbr1Aspca3Aspcl1Aspfl1Aspfo1Aspfu1Aspgl1Aspni5Aspni_DSM_1Aspnid1Aspor1Aspsy1Aspte1Asptu1Aspve1Aspwe1Aspzo1Eurhe1Monru1Neofi1Penbi1Penca1Pench1Penex1Penfe1Pengl1Penla1Theau1TotalAnnotation Description
Merops
3583994092733983722742733792914144073223734283643142442623094453812953703934142962149,671
131617915124813413691261898971699111112710293Water nucleophile; water bound by two Asp from monomer or dimer; all endopeptidases, from eukaryote organisms, viruses or virus-like organisms
111423411119Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on periplasmic side of cell membrane.
10784510187336285103378733767981067263Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on cytoplasmic side of cell membrane.
31333841293550353310342035331938353134524140333435413627953Cysteine nucleophile; catalytic residues in the order Cys, His, Asn (or Asp) in sequence
333333333333333233333223322379Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
2131111121111121111111128Cysteine nucleophile; catalytic residues in the order His, Glu (or Asp), Cys in sequence
11111111111111111112111125Cysteine nucleophile; catalytic residues in the order Glu, Cys, His in sequence
112Cysteine nucleophile; active peptidase is a homodimer with active site His and Glu from one monomer and Cys from the other. Catalytic residues in the order His, Glu, Cys in each monomer.
111121111111Cysteine nucleophile; catalytic residues in the order Cys, His, His in sequence
6562262444333623332363436642106Water nucleophile; water bound by Gln and Glu; all endopeptidases
11Water nucleophile; water bound by Glu; all self-cleaving endopeptidases
5555557755445549665664545555147Families of peptidase inhibitors not assigned to clans
111216
1113
11112118
11
211116
111211221321132121253323147
64432422414253321312231321272
11
10106716913777149141013567315910378553238Families of metallopeptidases not assigned to clans
101418152414131215162522121519191312717151410131014811407Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Glu, His or Asp
111121112111111111111111127Water nucleophile; water bound by single zinc ion ligated to His, Glu (within the motif HXXE) and His
111111111110Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HXXEH) and Glu
112Water nucleophile; water bound by two zinc ions ligated by Lys, Asp, Asp, Asp, Glu
8911778468576987644781110987786205Water nucleophile; water bound by two cobalt or manganese ions ligated by Asp, Asp, His, Glu, Glu
28272422262517153440263823254125161621223230253330293212734Water nucleophile; water bound by two zinc ions ligated by His (or Asp), Asp, Glu, Asp (or Glu), His
112014511167101481312151516813813610121115171178326Water nucleophile; water bound by two zinc ions ligated by His, His or Asp, Lys or Glu, His, His.
112Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Asp; membrane proteins with intramembrane active site.
11Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motifs HXXXD and HXH)
454325335112352313335544544294Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D)
1121111111111111118Water nucleophile; water bound by single zinc ion ligated to Asp, His and His.
11Asparagine nucleophile; catalytic residues in the order Asn, Glu in sequence; all self-processing endopeptidases
342213224432212138Serine or cysteine nucleophile; catalytic residues in the order His, Asp, Ser (or Cys) in sequence; all endopeptidases
22192322232020212117261918181920202020222023201821192122574Threonine, serine or cysteine nucleophile at the N-terminus of mature enzyme
561198765949649996771110981391183218Serine or cysteine nucleophile; catalytic residues in the order Cys (or Ser), His, Glu in sequence.
112Cysteine nucleophile at the N-terminus of mature enzyme; catalytic residues in the order Cys, Thr, His
121111122111121111123Serine or threonine nucleophile; N-terminal nucleophile
11Families of serine peptidases not assigned to clans
101111791186134956949969879777955220Serine nucleophile; catalytic residues in the order Asp, His, Ser in sequence in family S8, but family S53 differs
138168166771521495980147611531401161501411261217074851931339213216017496583,411Serine nucleophile; catalytic residues in the order Ser, Asp, His in sequence
610651241481761078105195914101189123201Serine nucleophile; catalytic residues in the order Ser, Lys (within the motif SXXK) in sequence
432233332175235524244555343296Serine nucleophile; catalytic residues in the order Ser, Lys (or His) in sequence
222122512233223221222222222158Serine nucleophile; catalytic residues in the order Ser, His, Asp in sequence
11112111110Serine nucleophile; catalytic residues in the order Ser, Glu, His
213211122211111122213212222246Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane
2722339313223121121454Families of peptidases of unknown catalytic mechanism not assigned to clans
111111111111111111111111111128
9101391110111612819108101011111212816151014912109315
1225
111111219
111111111110
325118738333338105734343310625216