Peptidases • Leotiomycetes
Annotations/GenomesAcema1Amore1Amyenc1Ascsa1Atrpi1Bgh5874_1Bissp1Blugr2BlugrR1_1Blugra1Blugra3_16Botci1Bulin1Cadsp1Calmar1Chalo1Cocst1Elyde1Erynec1Erypi2Glalo1Golci1Golor4Greab1Hyafin1Hymvar1Lacsu1Lepor2Leptod1Lopnit1_1Loppic1Lorju1Lorma1Mabrmo1Marbr1MelPMI1271_1Melbi2Melva1Oidma1Parpo1Phimu1Phisc1Pseel1Psene1Pseudest1Rhesp1Rhier1Rutfi1Sclsc1Spafl1Themi1Thest1XylPMI703_1TotalAnnotation Description
Merops
56225631429447714552514314614413532426472527767231541713815836915429532647043638967465749048141241426324647649565262217156764831317321250341934227728717513962419,602
341517154051955651814311850162488207181725292134333526353212102727433672841231311273216121579231,104Water nucleophile; water bound by two Asp from monomer or dimer; all endopeptidases, from eukaryote organisms, viruses or virus-like organisms
11111111111112Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on periplasmic side of cell membrane.
14745941134144178165821523911681917959106811131311118173141575643211399Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on cytoplasmic side of cell membrane.
29202719251629161616162125372029242518202517352428282639342722212422232835403315302614192031302418181914341,291Cysteine nucleophile; catalytic residues in the order Cys, His, Asn (or Asp) in sequence
44234333343243253333236473244334433455413433435223224178Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
211111211111312322111212223424531122111222123112287Cysteine nucleophile; catalytic residues in the order His, Glu (or Asp), Cys in sequence
212215131212111222131121111313311141211268Cysteine nucleophile; catalytic residues in the order Glu, Cys, His in sequence
22111121112Cysteine nucleophile; catalytic residues in the order Cys, His, His in sequence
11111111111111111113111111111111111111111144Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
722431111135411846434263589532246151334871175259210Water nucleophile; water bound by Gln and Glu; all endopeptidases
112Water nucleophile; water bound by Glu; all self-cleaving endopeptidases
45444343333545444446456554345345534454534546344454535222Families of peptidase inhibitors not assigned to clans
11111117
1111217
1225
1214
1222111111211212221211222222221211221212122168
6323644172764313234544854332386145352333118165
11114
74457112111142103846223244635111098662267785742273334115241Families of metallopeptidases not assigned to clans
169179176347766993315238129721715102320143128171915141916161722159222114713221211899711773Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Glu, His or Asp
11212531221112212222111221111121112123111165Water nucleophile; water bound by single zinc ion ligated to His, Glu (within the motif HXXE) and His
1112222222242112122312413111111111222211111211212111284Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HXXEH) and Glu
1088895115555891181081157941091098101091099749101010610129761098856511434Water nucleophile; water bound by two cobalt or manganese ions ligated by Asp, Asp, His, Glu, Glu
34182216335405544202341223823323526611242726244140343227262018292732301037411949352023172197351,180Water nucleophile; water bound by two zinc ions ligated by His (or Asp), Asp, Glu, Asp (or Glu), His
19111012142162222810259231217111424814172020232017101110918182218519261036171111885326631Water nucleophile; water bound by two zinc ions ligated by His, His or Asp, Lys or Glu, His, His.
111115Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motifs HXXXD and HXH)
44444434444434444444446444443244433444444444344444334204Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D)
1111211111111111111111124Water nucleophile; water bound by single zinc ion ligated to Asp, His and His.
11Asparagine nucleophile; catalytic residues in the order Asp, Asn in sequence; all self-processing endopeptidases
23141311113172411221423352122235442231222199Serine or cysteine nucleophile; catalytic residues in the order His, Asp, Ser (or Cys) in sequence; all endopeptidases
24222321241627161617152223272727222518172420402324222626252421262522212524282919242621182024252025222222281,220Threonine, serine or cysteine nucleophile at the N-terminus of mature enzyme
62534373332651351143226242666101384632375118311632384444435268Serine or cysteine nucleophile; catalytic residues in the order Cys (or Ser), His, Glu in sequence.
11Cysteine nucleophile at the N-terminus of mature enzyme; catalytic residues in the order Cys, Thr, His
42222111111111122111212112111243Serine or threonine nucleophile; N-terminal nucleophile
111115Families of serine peptidases not assigned to clans
3513121726423444312940153518264415131018231621424229302226131225253438630341846332514122253341,008Serine nucleophile; catalytic residues in the order Asp, His, Ser in sequence in family S8, but family S53 differs
238751081101814020438403837131813157629010615833441443567119184191139300283188198147157786918218428627454255295117526219816014410010241383047,490Serine nucleophile; catalytic residues in the order Ser, Asp, His in sequence
1843512216230521101075169827261917159221722192616236513139481218511Serine nucleophile; catalytic residues in the order Ser, Lys (within the motif SXXK) in sequence
33333343333333333323336333333443332233323324433322315160Serine nucleophile; catalytic residues in the order Ser, Lys (or His) in sequence
11Serine nucleophile; catalytic residues in the order Ser, Lys in sequence
2111323222111112111111222221112111122131111123211211279Serine nucleophile; catalytic residues in the order Ser, His, Asp in sequence
111121221111116Serine nucleophile; catalytic residues in the order Ser, Glu, His
6332423222213325341432526223334343446523223322333113154Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane
121111112111111112223Families of peptidases of unknown catalytic mechanism not assigned to clans
111111111111111111111121111111111111111111111111111153
181217151913201313151312133011141414121213122813181214131713111314121126231524101415121317151712171317815797
2111211111112111121111228
1124
521441114613113324545331344512643211124111