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Peptidases • Aspergillus heteromorphus CBS 117.55 v1.0
Annotations/GenomesAspeuc1Aspfu1Asphet1Aspni7Aspnid1Aspor1Aspscl1Aspste1Aspuva1TotalAnnotation Description
Merops
3632743013882914143833713523,137
1541415413161314108Water nucleophile; water bound by two Asp from monomer or dimer; all endopeptidases, from eukaryote organisms, viruses or virus-like organisms
114219Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on periplasmic side of cell membrane.
919833695787Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on cytoplasmic side of cell membrane.
355026341034314031291Cysteine nucleophile; catalytic residues in the order Cys, His, Asn (or Asp) in sequence
33333333428Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
111122210Cysteine nucleophile; catalytic residues in the order His, Glu (or Asp), Cys in sequence
11111117Cysteine nucleophile; catalytic residues in the order Glu, Cys, His in sequence
112Cysteine nucleophile; active peptidase is a homodimer with active site His and Glu from one monomer and Cys from the other. Catalytic residues in the order His, Glu, Cys in each monomer.
11Cysteine nucleophile; catalytic residues in the order Cys, His, His in sequence
62754372642Water nucleophile; water bound by Gln and Glu; all endopeptidases
11Water nucleophile; water bound by Glu; all self-cleaving endopeptidases
57455455545Families of peptidase inhibitors not assigned to clans
11
11
1211312112
4224161525
11
913777147201195Families of metallopeptidases not assigned to clans
131310141625181214135Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Glu, His or Asp
1111212110Water nucleophile; water bound by single zinc ion ligated to His, Glu (within the motif HXXE) and His
1113Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HXXEH) and Glu
112Water nucleophile; water bound by two zinc ions ligated by Lys, Asp, Asp, Asp, Glu
84685797761Water nucleophile; water bound by two cobalt or manganese ions ligated by Asp, Asp, His, Glu, Glu
221720264026233026230Water nucleophile; water bound by two zinc ions ligated by His (or Asp), Asp, Glu, Asp (or Glu), His
1471217813151410110Water nucleophile; water bound by two zinc ions ligated by His, His or Asp, Lys or Glu, His, His.
11Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Asp; membrane proteins with intramembrane active site.
53351143530Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D)
1111116Water nucleophile; water bound by single zinc ion ligated to Asp, His and His.
11Asparagine nucleophile; catalytic residues in the order Asn, Glu in sequence; all self-processing endopeptidases
12137Serine or cysteine nucleophile; catalytic residues in the order His, Asp, Ser (or Cys) in sequence; all endopeptidases
192020201726182021181Threonine, serine or cysteine nucleophile at the N-terminus of mature enzyme
665849108662Serine or cysteine nucleophile; catalytic residues in the order Cys (or Ser), His, Glu in sequence.
11Cysteine nucleophile at the N-terminus of mature enzyme; catalytic residues in the order Cys, Thr, His
111227Serine or threonine nucleophile; N-terminal nucleophile
11Families of serine peptidases not assigned to clans
108712491461080Serine nucleophile; catalytic residues in the order Asp, His, Ser in sequence in family S8, but family S53 differs
14759113160611531541311351,113Serine nucleophile; catalytic residues in the order Ser, Asp, His in sequence
5171017610653Serine nucleophile; catalytic residues in the order Ser, Lys (within the motif SXXK) in sequence
23231734530Serine nucleophile; catalytic residues in the order Ser, Lys (or His) in sequence
25122322221Serine nucleophile; catalytic residues in the order Ser, His, Asp in sequence
111115Serine nucleophile; catalytic residues in the order Ser, Glu, His
11112111110Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane
2233914125Families of peptidases of unknown catalytic mechanism not assigned to clans
1111111119
121110981912129102
11
1113
18238317271