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Peptidases • Earliella scabrosa CIRM-BRFM 1817 v1.0
Annotations/GenomesDicsq1Earsca1Fomfom1Hexnit1Polar1Polbr1Pyccin1Trave1TotalAnnotation Description
Merops
4074254124224434473414333,330
4445385152594462395Water nucleophile; water bound by two Asp from monomer or dimer; all endopeptidases, from eukaryote organisms, viruses or virus-like organisms
1221222113Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on cytoplasmic side of cell membrane.
1614181514121115115Cysteine nucleophile; catalytic residues in the order Cys, His, Asn (or Asp) in sequence
6364573438Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
311211211Cysteine nucleophile; catalytic residues in the order His, Glu (or Asp), Cys in sequence
11Cysteine nucleophile; catalytic residues in the order Cys, His, His in sequence
332345121Water nucleophile; water bound by Gln and Glu; all endopeptidases
2432332221Families of peptidase inhibitors not assigned to clans
111111118
3323332221
2322332219Families of metallopeptidases not assigned to clans
1522232116181622153Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Glu, His or Asp
111111118Water nucleophile; water bound by single zinc ion ligated to His, Glu (within the motif HXXE) and His
111111118Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HXXEH) and Glu
21137Water nucleophile; water bound by two zinc ions ligated by Lys, Asp, Asp, Asp, Glu
891099109973Water nucleophile; water bound by two cobalt or manganese ions ligated by Asp, Asp, His, Glu, Glu
1318181616161615128Water nucleophile; water bound by two zinc ions ligated by His (or Asp), Asp, Glu, Asp (or Glu), His
151411111111121297Water nucleophile; water bound by two zinc ions ligated by His, His or Asp, Lys or Glu, His, His.
111111118Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Asp; membrane proteins with intramembrane active site.
213Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motifs HXXXD and HXH)
6566565746Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D)
112Asparagine nucleophile; catalytic residues in the order Asp, Asn in sequence; all self-processing endopeptidases
2221252122222322178Threonine, serine or cysteine nucleophile at the N-terminus of mature enzyme
710551095556Serine or cysteine nucleophile; catalytic residues in the order Cys (or Ser), His, Glu in sequence.
3239383730312534266Serine nucleophile; catalytic residues in the order Asp, His, Ser in sequence in family S8, but family S53 differs
1361681641731841871341781,324Serine nucleophile; catalytic residues in the order Ser, Asp, His in sequence
56561174650Serine nucleophile; catalytic residues in the order Ser, Lys (within the motif SXXK) in sequence
4456443434Serine nucleophile; catalytic residues in the order Ser, Lys (or His) in sequence
111111118Serine nucleophile; catalytic residues in the order Ser, His, Asp in sequence
5243443328Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane
11114Families of peptidases of unknown catalytic mechanism not assigned to clans
111111118
5219171627201113175
123