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Peptidases • Thermoascus aurantiacus v1.0
Annotations/GenomesAspac1Aspbr1Aspca3Aspfo1Aspni5Aspnid1Aspsy1Aspve1Eurhe1Pench1Theau1TotalAnnotation Description
Merops
3583994093722914074282442952143,417
131617124668910101Water nucleophile; water bound by two Asp from monomer or dimer; all endopeptidases, from eukaryote organisms, viruses or virus-like organisms
1434113Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on periplasmic side of cell membrane.
107810332833777150Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on cytoplasmic side of cell membrane.
31333835102019313327277Cysteine nucleophile; catalytic residues in the order Cys, His, Asn (or Asp) in sequence
333333332329Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
213111110Cysteine nucleophile; catalytic residues in the order His, Glu (or Asp), Cys in sequence
11111117Cysteine nucleophile; catalytic residues in the order Glu, Cys, His in sequence
11Cysteine nucleophile; active peptidase is a homodimer with active site His and Glu from one monomer and Cys from the other. Catalytic residues in the order His, Glu, Cys in each monomer.
11114Cysteine nucleophile; catalytic residues in the order Cys, His, His in sequence
656643234241Water nucleophile; water bound by Gln and Glu; all endopeptidases
555554465549Families of peptidase inhibitors not assigned to clans
1113
1113
11
11
111132313117
64444313231
101069791373377Families of metallopeptidases not assigned to clans
10141814162219121011146Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Glu, His or Asp
1111111119Water nucleophile; water bound by single zinc ion ligated to His, Glu (within the motif HXXE) and His
11Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HXXEH) and Glu
8911856749673Water nucleophile; water bound by two cobalt or manganese ions ligated by Asp, Asp, His, Glu, Glu
28272425403841162512276Water nucleophile; water bound by two zinc ions ligated by His (or Asp), Asp, Glu, Asp (or Glu), His
11201416812168118124Water nucleophile; water bound by two zinc ions ligated by His, His or Asp, Lys or Glu, His, His.
11Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motifs HXXXD and HXH)
454512234232Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D)
112116Water nucleophile; water bound by single zinc ion ligated to Asp, His and His.
2248Serine or cysteine nucleophile; catalytic residues in the order His, Asp, Ser (or Cys) in sequence; all endopeptidases
22192320171919202022201Threonine, serine or cysteine nucleophile at the N-terminus of mature enzyme
5611746978366Serine or cysteine nucleophile; catalytic residues in the order Cys (or Ser), His, Glu in sequence.
1212118Serine or threonine nucleophile; N-terminal nucleophile
1011111145467574Serine nucleophile; catalytic residues in the order Asp, His, Ser in sequence in family S8, but family S53 differs
138168166149611401417092581,183Serine nucleophile; catalytic residues in the order Ser, Asp, His in sequence
61064168110355Serine nucleophile; catalytic residues in the order Ser, Lys (within the motif SXXK) in sequence
432315545234Serine nucleophile; catalytic residues in the order Ser, Lys (or His) in sequence
222223312120Serine nucleophile; catalytic residues in the order Ser, His, Asp in sequence
11125Serine nucleophile; catalytic residues in the order Ser, Glu, His
213121121216Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane
22332113Families of peptidases of unknown catalytic mechanism not assigned to clans
111111111110
91013108101012109101
1225
112
1113
321383338735130