Peptidases • Acaromyces ingoldii MCA 4198 v1.0
Annotations/GenomesAcain1Exova1Jamsp1Malgl1Meimi1Psean1_1Psehu1Rhodsp1Rhosp1Schco3Spore1Tescy1Tilan2Tilwa1Ustma1Ustsp1TotalAnnotation Description
Merops
2172061661381971491501691653451561591561601481672,848
9131117108510929768687163Water nucleophile; water bound by two Asp from monomer or dimer; all endopeptidases, from eukaryote organisms, viruses or virus-like organisms
121121112211111120Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on cytoplasmic side of cell membrane.
112Water nucleophile; water bound by two Asp
16141513181415161520131410111810232Cysteine nucleophile; catalytic residues in the order Cys, His, Asn (or Asp) in sequence
222221232522222235Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
222131122331124Cysteine nucleophile; catalytic residues in the order His, Glu (or Asp), Cys in sequence
11Cysteine nucleophile; catalytic residues in the order Glu, Cys, His in sequence
112Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
11Water nucleophile; water bound by Gln and Glu; all endopeptidases
232232232223232237Families of peptidase inhibitors not assigned to clans
1113
111111121211115
2331127113125
21311113131222327Families of metallopeptidases not assigned to clans
86779757722797978132Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Glu, His or Asp
11112211111114Water nucleophile; water bound by single zinc ion ligated to His, Glu (within the motif HXXE) and His
31116Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HXXEH) and Glu
11111121111113Water nucleophile; water bound by two zinc ions ligated by Lys, Asp, Asp, Asp, Glu
6556553571055544686Water nucleophile; water bound by two cobalt or manganese ions ligated by Asp, Asp, His, Glu, Glu
118877997923118711613154Water nucleophile; water bound by two zinc ions ligated by His (or Asp), Asp, Glu, Asp (or Glu), His
93325445101245534684Water nucleophile; water bound by two zinc ions ligated by His, His or Asp, Lys or Glu, His, His.
11114Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Asp; membrane proteins with intramembrane active site.
554455445555655678Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D)
111115Asparagine nucleophile; catalytic residues in the order Asp, Asn in sequence; all self-processing endopeptidases
11Asparagine nucleophile; all self-processing endopeptidases
112Serine or cysteine nucleophile; catalytic residues in the order His, Asp, Ser (or Cys) in sequence; all endopeptidases
19201817191817181722201918201818298Threonine, serine or cysteine nucleophile at the N-terminus of mature enzyme
434384342744351463Serine or cysteine nucleophile; catalytic residues in the order Cys (or Ser), His, Glu in sequence.
11Cysteine nucleophile at the N-terminus of mature enzyme; catalytic residues in the order Cys, Thr, His
121116Serine or threonine nucleophile; N-terminal nucleophile
69642241622732359Serine nucleophile; catalytic residues in the order Asp, His, Ser in sequence in family S8, but family S53 differs
917456296451555542132505145495054948Serine nucleophile; catalytic residues in the order Ser, Asp, His in sequence
222223431213229Serine nucleophile; catalytic residues in the order Ser, Lys (within the motif SXXK) in sequence
22233123311331232Serine nucleophile; catalytic residues in the order Ser, Lys (or His) in sequence
2114Serine nucleophile; catalytic residues in the order Ser, His, Asp in sequence
23322212341331133Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane
112Families of peptidases of unknown catalytic mechanism not assigned to clans
111111111111111116
101391411677141289139610158
22
112
245344212229