Peptidases • Piromyces finnis v3.0
Annotations/GenomesAnasp1Batde5Coere1Conco1Ganpr1Gloin1Neosp1Orpsp1_1Phchr2Phybl2PirE2_1Pirfi3Trire2TotalAnnotation Description
Merops
3313142044393413074434953542843952282864,421
11034261222462287115267Water nucleophile; water bound by two Asp from monomer or dimer; all endopeptidases, from eukaryote organisms, viruses or virus-like organisms
123Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on periplasmic side of cell membrane.
21124412422328Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on cytoplasmic side of cell membrane.
18192022213130421629162021305Cysteine nucleophile; catalytic residues in the order Cys, His, Asn (or Asp) in sequence
113457421103713143105Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
2212331231121Cysteine nucleophile; catalytic residues in the order His, Glu (or Asp), Cys in sequence
11111117Cysteine nucleophile; catalytic residues in the order Glu, Cys, His in sequence
213Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
1113Cysteine nucleophile; catalytic residues in the order Cys, His, His in sequence
212117Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
11617Water nucleophile; water bound by Gln and Glu; all endopeptidases
11Water nucleophile; water bound by Glu; all self-cleaving endopeptidases
12547552465665595Families of peptidase inhibitors not assigned to clans
11
13121331345
11
11
112
111111118
111121411114
1113
11
111114183184144Families of metallopeptidases not assigned to clans
48351829182045116917663011462Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Glu, His or Asp
130611122347Water nucleophile; water bound by single zinc ion ligated to His, Glu (within the motif HXXE) and His
11Water nucleophile; water bound by single zinc ion ligated to His, Asp and His
22411514121125Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HXXEH) and Glu
32324755134342Water nucleophile; water bound by two zinc ions ligated by Lys, Asp, Asp, Asp, Glu
578877108912658100Water nucleophile; water bound by two cobalt or manganese ions ligated by Asp, Asp, His, Glu, Glu
8111040161215715156518178Water nucleophile; water bound by two zinc ions ligated by His (or Asp), Asp, Glu, Asp (or Glu), His
145513813109111374Water nucleophile; water bound by two zinc ions ligated by His, His or Asp, Lys or Glu, His, His.
111111118Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Asp; membrane proteins with intramembrane active site.
11Water nucleophile; water bound by two zinc ions ligated by Asp, Glu, His, His, Glu
563434746555461Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D)
11Water nucleophile; water bound by single zinc ion ligated to Asp, His and His.
112Asparagine nucleophile; catalytic residues in the order Asp, Asn in sequence; all self-processing endopeptidases
91475131284111138Serine or cysteine nucleophile; catalytic residues in the order His, Asp, Ser (or Cys) in sequence; all endopeptidases
15151824212731172217151723262Threonine, serine or cysteine nucleophile at the N-terminus of mature enzyme
154256396313452Serine or cysteine nucleophile; catalytic residues in the order Cys (or Ser), His, Glu in sequence.
55Cysteine nucleophile at the N-terminus of mature enzyme; catalytic residues in the order Cys, Thr, His
41121413Serine or threonine nucleophile; N-terminal nucleophile
11Families of serine peptidases not assigned to clans
43244641716421219381714274Serine nucleophile; catalytic residues in the order Asp, His, Ser in sequence in family S8, but family S53 differs
91444990119781251181275512758921,173Serine nucleophile; catalytic residues in the order Ser, Asp, His in sequence
1316223633Serine nucleophile; catalytic residues in the order Ser, Lys (within the motif SXXK) in sequence
6551057822423261Serine nucleophile; catalytic residues in the order Ser, Lys (or His) in sequence
11123121311118Serine nucleophile; catalytic residues in the order Ser, His, Asp in sequence
22Serine nucleophile; catalytic residues in the order His, Ser within the motif HXS.
10315631564745372Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane
2114Families of peptidases of unknown catalytic mechanism not assigned to clans
21111411122118
15241417171733501426341515291
11
2121211212
11
2226