Peptidases • Aspergillus niger NRRL3
Annotations/GenomesAspac1Aspbr1Aspca3Aspcl1Aspfl1Aspfo1Aspfu1Aspgl1Aspni5Aspni_DSM_1Aspni_NRRL3_1Aspnid1Aspor1Aspsy1Aspte1Asptu1Aspve1Aspwe1Aspzo1TotalAnnotation Description
Merops
3583994092733983722742733794042914144073223734283643146,452
1316179151248131541369126189199Water nucleophile; water bound by two Asp from monomer or dimer; all endopeptidases, from eukaryote organisms, viruses or virus-like organisms
111423416Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on periplasmic side of cell membrane.
107845101879336285103378199Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on cytoplasmic side of cell membrane.
313338412935503533371034203533193835586Cysteine nucleophile; catalytic residues in the order Cys, His, Asn (or Asp) in sequence
33333333343333332354Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
2131111112111118Cysteine nucleophile; catalytic residues in the order His, Glu (or Asp), Cys in sequence
1111111111111114Cysteine nucleophile; catalytic residues in the order Glu, Cys, His in sequence
112Cysteine nucleophile; active peptidase is a homodimer with active site His and Glu from one monomer and Cys from the other. Catalytic residues in the order His, Glu, Cys in each monomer.
11112118Cysteine nucleophile; catalytic residues in the order Cys, His, His in sequence
65622624454333623369Water nucleophile; water bound by Gln and Glu; all endopeptidases
11Water nucleophile; water bound by Glu; all self-cleaving endopeptidases
55555577555445549696Families of peptidase inhibitors not assigned to clans
1111217
1113
1113
11
111211221132113225
6443242244142533255
11
10106716913777714914101356170Families of metallopeptidases not assigned to clans
101418152414131215151625221215191913291Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Glu, His or Asp
111121111211111118Water nucleophile; water bound by single zinc ion ligated to His, Glu (within the motif HXXE) and His
111111118Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HXXEH) and Glu
112Water nucleophile; water bound by two zinc ions ligated by Lys, Asp, Asp, Asp, Glu
89117784681057698764130Water nucleophile; water bound by two cobalt or manganese ions ligated by Asp, Asp, His, Glu, Glu
282724222625171534284026382325412516480Water nucleophile; water bound by two zinc ions ligated by His (or Asp), Asp, Glu, Asp (or Glu), His
11201451116710141681312151516813224Water nucleophile; water bound by two zinc ions ligated by His, His or Asp, Lys or Glu, His, His.
112Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Asp; membrane proteins with intramembrane active site.
11Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motifs HXXXD and HXH)
45432533551123523157Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D)
1121111111112Water nucleophile; water bound by single zinc ion ligated to Asp, His and His.
11Asparagine nucleophile; catalytic residues in the order Asn, Glu in sequence; all self-processing endopeptidases
342213224427Serine or cysteine nucleophile; catalytic residues in the order His, Asp, Ser (or Cys) in sequence; all endopeptidases
221923222320202121201726191818192020368Threonine, serine or cysteine nucleophile at the N-terminus of mature enzyme
5611987659949649996131Serine or cysteine nucleophile; catalytic residues in the order Cys (or Ser), His, Glu in sequence.
11Cysteine nucleophile at the N-terminus of mature enzyme; catalytic residues in the order Cys, Thr, His
12111112211115Serine or threonine nucleophile; N-terminal nucleophile
11Families of serine peptidases not assigned to clans
101111791186131349569499154Serine nucleophile; catalytic residues in the order Asp, His, Ser in sequence in family S8, but family S53 differs
138168166771521495980147164611531401161501411261212,308Serine nucleophile; catalytic residues in the order Ser, Asp, His in sequence
61065124148111761078105121Serine nucleophile; catalytic residues in the order Ser, Lys (within the motif SXXK) in sequence
43223333221752355257Serine nucleophile; catalytic residues in the order Ser, Lys (or His) in sequence
22212251222332232240Serine nucleophile; catalytic residues in the order Ser, His, Asp in sequence
111121119Serine nucleophile; catalytic residues in the order Ser, Glu, His
21321112222111111227Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane
2722323931322344Families of peptidases of unknown catalytic mechanism not assigned to clans
11111111111111111118
91013911101116121081910810101111198
1225
1113
1111116
325118738333338105166