Peptidases • Thielavia appendiculata CBS 731.68 v1.0
Annotations/GenomesNeucr2Spoth2Thiap1Thiar1Thihy1Thite2Trire2TotalAnnotation Description
Merops
2422432562692312562861,783
19171816142615125Water nucleophile; water bound by two Asp from monomer or dimer; all endopeptidases, from eukaryote organisms, viruses or virus-like organisms
33Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on periplasmic side of cell membrane.
512323319Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on cytoplasmic side of cell membrane.
16201616151521119Cysteine nucleophile; catalytic residues in the order Cys, His, Asn (or Asp) in sequence
335333323Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
11111117Cysteine nucleophile; catalytic residues in the order His, Glu (or Asp), Cys in sequence
11111117Cysteine nucleophile; catalytic residues in the order Glu, Cys, His in sequence
213Cysteine nucleophile; catalytic residues in the order Cys, His, His in sequence
111115Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
225344626Water nucleophile; water bound by Gln and Glu; all endopeptidases
334355528Families of peptidase inhibitors not assigned to clans
32222213
115544121
213231113Families of metallopeptidases not assigned to clans
12610101291170Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Glu, His or Asp
233332319Water nucleophile; water bound by single zinc ion ligated to His, Glu (within the motif HXXE) and His
22421112Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HXXEH) and Glu
1088788857Water nucleophile; water bound by two cobalt or manganese ions ligated by Asp, Asp, His, Glu, Glu
14151516121118101Water nucleophile; water bound by two zinc ions ligated by His (or Asp), Asp, Glu, Asp (or Glu), His
10879791363Water nucleophile; water bound by two zinc ions ligated by His, His or Asp, Lys or Glu, His, His.
443334425Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D)
11Water nucleophile; water bound by single zinc ion ligated to Asp, His and His.
1113Serine or cysteine nucleophile; catalytic residues in the order His, Asp, Ser (or Cys) in sequence; all endopeptidases
23202121192023147Threonine, serine or cysteine nucleophile at the N-terminus of mature enzyme
247463430Serine or cysteine nucleophile; catalytic residues in the order Cys (or Ser), His, Glu in sequence.
11Cysteine nucleophile at the N-terminus of mature enzyme; catalytic residues in the order Cys, Thr, His
44Serine or threonine nucleophile; N-terminal nucleophile
11Families of serine peptidases not assigned to clans
81112141091478Serine nucleophile; catalytic residues in the order Asp, His, Ser in sequence in family S8, but family S53 differs
71807390638692555Serine nucleophile; catalytic residues in the order Ser, Asp, His in sequence
574927640Serine nucleophile; catalytic residues in the order Ser, Lys (within the motif SXXK) in sequence
233333219Serine nucleophile; catalytic residues in the order Ser, Lys (or His) in sequence
11111117Serine nucleophile; catalytic residues in the order Ser, His, Asp in sequence
432232319Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane
21111118
13131513171415100
1332211