Peptidases • Trichoplax adhaerens Grell-BS-1999 v1.0
Annotations/GenomesTriad1TotalAnnotation Description
Merops
398398
1212Water nucleophile; water bound by two Asp from monomer or dimer; all endopeptidases, from eukaryote organisms, viruses or virus-like organisms
44Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on cytoplasmic side of cell membrane.
3030Cysteine nucleophile; catalytic residues in the order Cys, His, Asn (or Asp) in sequence
88Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
33Cysteine nucleophile; catalytic residues in the order His, Glu (or Asp), Cys in sequence
11Cysteine nucleophile; catalytic residues in the order Glu, Cys, His in sequence
11Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
66Families of peptidase inhibitors not assigned to clans
33
33
22
11
3535
11
1111
11Families of metallopeptidases not assigned to clans
2222Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Glu, His or Asp
88Water nucleophile; water bound by single zinc ion ligated to His, Glu (within the motif HXXE) and His
11Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HXXEH) and Glu
44Water nucleophile; water bound by two zinc ions ligated by Lys, Asp, Asp, Asp, Glu
1010Water nucleophile; water bound by two cobalt or manganese ions ligated by Asp, Asp, His, Glu, Glu
1414Water nucleophile; water bound by two zinc ions ligated by His (or Asp), Asp, Glu, Asp (or Glu), His
99Water nucleophile; water bound by two zinc ions ligated by His, His or Asp, Lys or Glu, His, His.
11Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Asp; membrane proteins with intramembrane active site.
44Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D)
2323Serine or cysteine nucleophile; catalytic residues in the order His, Asp, Ser (or Cys) in sequence; all endopeptidases
2424Threonine, serine or cysteine nucleophile at the N-terminus of mature enzyme
22Serine or cysteine nucleophile; catalytic residues in the order Cys (or Ser), His, Glu in sequence.
11Serine nucleophile; catalytic residues in the order Asp, His, Ser in sequence in family S8, but family S53 differs
106106Serine nucleophile; catalytic residues in the order Ser, Asp, His in sequence
11Serine nucleophile; catalytic residues in the order Ser, Lys (within the motif SXXK) in sequence
1212Serine nucleophile; catalytic residues in the order Ser, Lys (or His) in sequence
11Serine nucleophile; catalytic residues in the order Ser, Lys in sequence
33Serine nucleophile; catalytic residues in the order Ser, His, Asp in sequence
55Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane
22Families of peptidases of unknown catalytic mechanism not assigned to clans
2323