Peptidases • Monascus ruber NRRL 1597 v1.0
Annotations/GenomesAspac1Aspbr1Aspca3Aspfo1Aspgl1Aspnid1Aspsy1Asptu1Aspve1Aspwe1Aspzo1Eurhe1Monru1Pench1Theau1TotalAnnotation Description
Merops
3583994093722732914073734283643142442622952145,003
1316171284612618989910157Water nucleophile; water bound by two Asp from monomer or dimer; all endopeptidases, from eukaryote organisms, viruses or virus-like organisms
1434113Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on periplasmic side of cell membrane.
107810833281033787377186Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on cytoplasmic side of cell membrane.
313338353510203319383531343327452Cysteine nucleophile; catalytic residues in the order Cys, His, Asn (or Asp) in sequence
33333333323332343Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
2131111121115Cysteine nucleophile; catalytic residues in the order His, Glu (or Asp), Cys in sequence
11111111111112Cysteine nucleophile; catalytic residues in the order Glu, Cys, His in sequence
11Cysteine nucleophile; active peptidase is a homodimer with active site His and Glu from one monomer and Cys from the other. Catalytic residues in the order His, Glu, Cys in each monomer.
111115Cysteine nucleophile; catalytic residues in the order Cys, His, His in sequence
65664436233324259Water nucleophile; water bound by Gln and Glu; all endopeptidases
55557545496655581Families of peptidase inhibitors not assigned to clans
11215
1113
112
11
11
1111232132123124
6444245332133246
1010697791013567333108Families of metallopeptidases not assigned to clans
10141814121622151919131271011212Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Glu, His or Asp
111111111111113Water nucleophile; water bound by single zinc ion ligated to His, Glu (within the motif HXXE) and His
11114Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HXXEH) and Glu
8911865687644796104Water nucleophile; water bound by two cobalt or manganese ions ligated by Asp, Asp, His, Glu, Glu
282724251540382541251616212512378Water nucleophile; water bound by two zinc ions ligated by His (or Asp), Asp, Glu, Asp (or Glu), His
11201416108121516813813118183Water nucleophile; water bound by two zinc ions ligated by His, His or Asp, Lys or Glu, His, His.
11Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motifs HXXXD and HXH)
45453125231334247Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D)
11211118Water nucleophile; water bound by single zinc ion ligated to Asp, His and His.
2124413Serine or cysteine nucleophile; catalytic residues in the order His, Asp, Ser (or Cys) in sequence; all endopeptidases
221923202117191819202020202022300Threonine, serine or cysteine nucleophile at the N-terminus of mature enzyme
5611754699967783102Serine or cysteine nucleophile; catalytic residues in the order Cys (or Ser), His, Glu in sequence.
1211211110Serine or threonine nucleophile; N-terminal nucleophile
1011111164594996975116Serine nucleophile; catalytic residues in the order Asp, His, Ser in sequence in family S8, but family S53 differs
1381681661498061140150141126121707492581,734Serine nucleophile; catalytic residues in the order Ser, Asp, His in sequence
61064416781051910390Serine nucleophile; catalytic residues in the order Ser, Lys (within the motif SXXK) in sequence
43233153552425249Serine nucleophile; catalytic residues in the order Ser, Lys (or His) in sequence
22221232322122129Serine nucleophile; catalytic residues in the order Ser, His, Asp in sequence
1112117Serine nucleophile; catalytic residues in the order Ser, Glu, His
21312211112221224Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane
223332231122Families of peptidases of unknown catalytic mechanism not assigned to clans
11111111111111115
910131016810101011111212109161
1225
112
111115
32173833381057335155