Peptidases • Tothia fuscella CBS 130266 v1.0
Annotations/GenomesAplpr1Aulhe2Botdo1Leppa1Macph1Neopa1Patat1Sacpr1Totfu1Tryvi1Zoprh1TotalAnnotation Description
Merops
2943143484053632592903883565133,530
25201723201129261930220Water nucleophile; water bound by two Asp from monomer or dimer; all endopeptidases, from eukaryote organisms, viruses or virus-like organisms
1113Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on periplasmic side of cell membrane.
565952653854Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on cytoplasmic side of cell membrane.
11Water nucleophile; water bound by two Asp
22222922272526282632259Cysteine nucleophile; catalytic residues in the order Cys, His, Asn (or Asp) in sequence
235222324429Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
232113221118Cysteine nucleophile; catalytic residues in the order His, Glu (or Asp), Cys in sequence
211138Cysteine nucleophile; catalytic residues in the order Glu, Cys, His in sequence
213Cysteine nucleophile; catalytic residues in the order Cys, His, His in sequence
11121111110Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
311312314221Water nucleophile; water bound by Gln and Glu; all endopeptidases
555345455546Families of peptidase inhibitors not assigned to clans
11
1124
1211221111
3111466628
11
5176333110645Families of metallopeptidases not assigned to clans
911142518178221221157Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Glu, His or Asp
224543132430Water nucleophile; water bound by single zinc ion ligated to His, Glu (within the motif HXXE) and His
224312221221Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HXXEH) and Glu
568876668767Water nucleophile; water bound by two cobalt or manganese ions ligated by Asp, Asp, His, Glu, Glu
20282024281721241526223Water nucleophile; water bound by two zinc ions ligated by His (or Asp), Asp, Glu, Asp (or Glu), His
10914171481091217120Water nucleophile; water bound by two zinc ions ligated by His, His or Asp, Lys or Glu, His, His.
11Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motifs HXXXD and HXH)
333333333431Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D)
23223122219Serine or cysteine nucleophile; catalytic residues in the order His, Asp, Ser (or Cys) in sequence; all endopeptidases
24222019222321232420218Threonine, serine or cysteine nucleophile at the N-terminus of mature enzyme
325832343538Serine or cysteine nucleophile; catalytic residues in the order Cys (or Ser), His, Glu in sequence.
112Cysteine nucleophile at the N-terminus of mature enzyme; catalytic residues in the order Cys, Thr, His
111312111214Serine or threonine nucleophile; N-terminal nucleophile
1015151313612222621153Serine nucleophile; catalytic residues in the order Asp, His, Ser in sequence in family S8, but family S53 differs
9911711016914678981521381921,299Serine nucleophile; catalytic residues in the order Ser, Asp, His in sequence
9381012231361682Serine nucleophile; catalytic residues in the order Ser, Lys (within the motif SXXK) in sequence
443333313330Serine nucleophile; catalytic residues in the order Ser, Lys (or His) in sequence
212222211116Serine nucleophile; catalytic residues in the order Ser, His, Asp in sequence
433545333538Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane
112Families of peptidases of unknown catalytic mechanism not assigned to clans
1111111119
111130810149111158173
11
113311253424