Peptidases • Aspergillus fumigatus A1163
Annotations/GenomesAspac1Aspbr1Aspca3Aspcl1Aspfl1Aspfo1Aspfu1Aspfu_A1163_1Aspgl1Aspni5Aspni_DSM_1Aspnid1Aspor1Aspsy1Aspte1Asptu1Aspve1Aspwe1Aspzo1TotalAnnotation Description
Merops
3583994092733983722742682733792914144073223734283643146,316
131617915124481341369126189188Water nucleophile; water bound by two Asp from monomer or dimer; all endopeptidases, from eukaryote organisms, viruses or virus-like organisms
111423416Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on periplasmic side of cell membrane.
107845101287336285103378192Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on cytoplasmic side of cell membrane.
313338412935505135331034203533193835600Cysteine nucleophile; catalytic residues in the order Cys, His, Asn (or Asp) in sequence
33333333333333332353Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
2131111112111118Cysteine nucleophile; catalytic residues in the order His, Glu (or Asp), Cys in sequence
1111111111111114Cysteine nucleophile; catalytic residues in the order Glu, Cys, His in sequence
112Cysteine nucleophile; active peptidase is a homodimer with active site His and Glu from one monomer and Cys from the other. Catalytic residues in the order His, Glu, Cys in each monomer.
11112118Cysteine nucleophile; catalytic residues in the order Cys, His, His in sequence
65622622444333623366Water nucleophile; water bound by Gln and Glu; all endopeptidases
112Water nucleophile; water bound by Glu; all self-cleaving endopeptidases
55555577755445549698Families of peptidase inhibitors not assigned to clans
111216
1113
11114
11
111211222132113226
6443242224142533253
112
101067169131377714914101356176Families of metallopeptidases not assigned to clans
101418152414131312151625221215191913289Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Glu, His or Asp
11112111211111117Water nucleophile; water bound by single zinc ion ligated to His, Glu (within the motif HXXE) and His
111111118Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HXXEH) and Glu
112Water nucleophile; water bound by two zinc ions ligated by Lys, Asp, Asp, Asp, Glu
8911778446857698764124Water nucleophile; water bound by two cobalt or manganese ions ligated by Asp, Asp, His, Glu, Glu
282724222625171615344026382325412516468Water nucleophile; water bound by two zinc ions ligated by His (or Asp), Asp, Glu, Asp (or Glu), His
1120145111676101481312151516813214Water nucleophile; water bound by two zinc ions ligated by His, His or Asp, Lys or Glu, His, His.
112Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Asp; membrane proteins with intramembrane active site.
11Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motifs HXXXD and HXH)
45432534351123523156Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D)
112111111111Water nucleophile; water bound by single zinc ion ligated to Asp, His and His.
11Asparagine nucleophile; catalytic residues in the order Asn, Glu in sequence; all self-processing endopeptidases
3422213224429Serine or cysteine nucleophile; catalytic residues in the order His, Asp, Ser (or Cys) in sequence; all endopeptidases
221923222320201921211726191818192020367Threonine, serine or cysteine nucleophile at the N-terminus of mature enzyme
5611987675949649996129Serine or cysteine nucleophile; catalytic residues in the order Cys (or Ser), His, Glu in sequence.
112Cysteine nucleophile at the N-terminus of mature enzyme; catalytic residues in the order Cys, Thr, His
12111112211115Serine or threonine nucleophile; N-terminal nucleophile
112Families of serine peptidases not assigned to clans
10111179118761349569499148Serine nucleophile; catalytic residues in the order Asp, His, Ser in sequence in family S8, but family S53 differs
13816816677152149595780147611531401161501411261212,201Serine nucleophile; catalytic residues in the order Ser, Asp, His in sequence
6106512411481761078105111Serine nucleophile; catalytic residues in the order Ser, Lys (within the motif SXXK) in sequence
43223333321752355258Serine nucleophile; catalytic residues in the order Ser, Lys (or His) in sequence
22212254122332232242Serine nucleophile; catalytic residues in the order Ser, His, Asp in sequence
11112118Serine nucleophile; catalytic residues in the order Ser, Glu, His
21321111222111111226Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane
2722233931322344Families of peptidases of unknown catalytic mechanism not assigned to clans
11111111111111111118
9101391110119161281910810101111197
1225
1113
1111116
32511818738333338105184