Peptidases • Phellinus igniarius CCBS 575 v1.0
Annotations/GenomesFomme1Onnsc1Phefer1Pheign1_1Porchr1Pornie1_2Ricfib1Ricmel1Schpa1Triab1_1TotalAnnotation Description
Merops
3162942863103273543433483303913,299
33593053384356603242446Water nucleophile; water bound by two Asp from monomer or dimer; all endopeptidases, from eukaryote organisms, viruses or virus-like organisms
111112221113Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on cytoplasmic side of cell membrane.
21211820222618151921201Cysteine nucleophile; catalytic residues in the order Cys, His, Asn (or Asp) in sequence
56664108871070Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
12126Cysteine nucleophile; catalytic residues in the order His, Glu (or Asp), Cys in sequence
11Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
11Water nucleophile; water bound by Gln and Glu; all endopeptidases
333333333330Families of peptidase inhibitors not assigned to clans
112
1111111119
236476445546
234344224230Families of metallopeptidases not assigned to clans
13111219202016121214149Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Glu, His or Asp
1111116Water nucleophile; water bound by single zinc ion ligated to His, Glu (within the motif HXXE) and His
11111311111Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HXXEH) and Glu
11111122212Water nucleophile; water bound by two zinc ions ligated by Lys, Asp, Asp, Asp, Glu
11997910101010994Water nucleophile; water bound by two cobalt or manganese ions ligated by Asp, Asp, His, Glu, Glu
13101110101012111212111Water nucleophile; water bound by two zinc ions ligated by His (or Asp), Asp, Glu, Asp (or Glu), His
89109119171299103Water nucleophile; water bound by two zinc ions ligated by His, His or Asp, Lys or Glu, His, His.
111121111111Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Asp; membrane proteins with intramembrane active site.
11Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motifs HXXXD and HXH)
766666556558Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D)
11215Asparagine nucleophile; catalytic residues in the order Asp, Asn in sequence; all self-processing endopeptidases
20202021242721212222218Threonine, serine or cysteine nucleophile at the N-terminus of mature enzyme
755568437555Serine or cysteine nucleophile; catalytic residues in the order Cys (or Ser), His, Glu in sequence.
1113Serine or threonine nucleophile; N-terminal nucleophile
81411613918161333141Serine nucleophile; catalytic residues in the order Asp, His, Ser in sequence in family S8, but family S53 differs
11685101991131221001081271371,108Serine nucleophile; catalytic residues in the order Ser, Asp, His in sequence
114648334539Serine nucleophile; catalytic residues in the order Ser, Lys (within the motif SXXK) in sequence
438633553545Serine nucleophile; catalytic residues in the order Ser, Lys (or His) in sequence
1111111119Serine nucleophile; catalytic residues in the order Ser, His, Asp in sequence
322334333329Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane
111111111110
31141116161822352036219
112116
11