Peptidases • Acephala macrosclerotiorum EW76-UTF0540 v1.0
Annotations/GenomesAcema1Ascsa1Cadsp1Chalo1Marbr1Melbi2Phisc1Rhier1TotalAnnotation Description
Merops
5622947256722464956484194,061
3415315010274132240Water nucleophile; water bound by two Asp from monomer or dimer; all endopeptidases, from eukaryote organisms, viruses or virus-like organisms
11Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on periplasmic side of cell membrane.
145171681317797Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on cytoplasmic side of cell membrane.
2919372923352630228Cysteine nucleophile; catalytic residues in the order Cys, His, Asn (or Asp) in sequence
4335354532Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
2113122315Cysteine nucleophile; catalytic residues in the order His, Glu (or Asp), Cys in sequence
253113116Cysteine nucleophile; catalytic residues in the order Glu, Cys, His in sequence
1124Cysteine nucleophile; catalytic residues in the order Cys, His, His in sequence
1111116Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
74418268756Water nucleophile; water bound by Gln and Glu; all endopeptidases
11Water nucleophile; water bound by Glu; all self-cleaving endopeptidases
4454455435Families of peptidase inhibitors not assigned to clans
112
1113
213
121112210
6377335236
11
75108277349Families of metallopeptidases not assigned to clans
169332316172112147Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Glu, His or Asp
1121211110Water nucleophile; water bound by single zinc ion ligated to His, Glu (within the motif HXXE) and His
1212221213Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HXXEH) and Glu
108111041012974Water nucleophile; water bound by two cobalt or manganese ions ligated by Asp, Asp, His, Glu, Glu
3416413818274120235Water nucleophile; water bound by two zinc ions ligated by His (or Asp), Asp, Glu, Asp (or Glu), His
191225239182611143Water nucleophile; water bound by two zinc ions ligated by His, His or Asp, Lys or Glu, His, His.
112Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motifs HXXXD and HXH)
4444344431Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D)
11111117Water nucleophile; water bound by single zinc ion ligated to Asp, His and His.
2174343226Serine or cysteine nucleophile; catalytic residues in the order His, Asp, Ser (or Cys) in sequence; all endopeptidases
2421272721242625195Threonine, serine or cysteine nucleophile at the N-terminus of mature enzyme
631311356451Serine or cysteine nucleophile; catalytic residues in the order Cys (or Ser), His, Glu in sequence.
42121111Serine or threonine nucleophile; N-terminal nucleophile
112Families of serine peptidases not assigned to clans
3517403512253425223Serine nucleophile; catalytic residues in the order Asp, His, Ser in sequence in family S8, but family S53 differs
238110315290691842951601,661Serine nucleophile; catalytic residues in the order Ser, Asp, His in sequence
18530212222313134Serine nucleophile; catalytic residues in the order Ser, Lys (within the motif SXXK) in sequence
3333233323Serine nucleophile; catalytic residues in the order Ser, Lys (or His) in sequence
2112121212Serine nucleophile; catalytic residues in the order Ser, His, Asp in sequence
1113Serine nucleophile; catalytic residues in the order Ser, Glu, His
6235462331Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane
11114Families of peptidases of unknown catalytic mechanism not assigned to clans
111111118
1815301411231517143
2211219
514646228