Peptidases • Lyophyllum atratum CBS 144462 v1.0
Annotations/GenomesAgabi_varbisH97_2Amamu1Amath1Armga1Armost1Armosto1Auramp1Conpu1Copang1Copci_AmutBmut1Copmar1Copmic2Crafun1Crula1Cylto1Fishe1Fompi3Galma1Gymlu1Hebcy2Hypsu1Lacam2Lacbi2Lenti6_1Lyoat1Ompol1Phchr2Phohig1PleosPC15_2Plucer1PosplRSB12_1Ricmel1Schco3TotalAnnotation Description
Merops
28734631864954751035143248529236439033536433727433838856128637932433842634425135441934733433434834512,397
2437194843362259222025153027183039275516383032442620622624254760291,075Water nucleophile; water bound by two Asp from monomer or dimer; all endopeptidases, from eukaryote organisms, viruses or virus-like organisms
11Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on periplasmic side of cell membrane.
211213111321224131222111211122252Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on cytoplasmic side of cell membrane.
1517Water nucleophile; water bound by two Asp
18914301918232522141621151513171420231717162910171816181814131520584Cysteine nucleophile; catalytic residues in the order Cys, His, Asn (or Asp) in sequence
3431791011025911610136986101011694955631296685599Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
231422213111131151231122322255Cysteine nucleophile; catalytic residues in the order His, Glu (or Asp), Cys in sequence
11Cysteine nucleophile; catalytic residues in the order Glu, Cys, His in sequence
132514621223111131186Water nucleophile; water bound by Gln and Glu; all endopeptidases
469332227668364229125510113415423232156Families of peptidase inhibitors not assigned to clans
1181837
11
11111117
11
1111121223111112222111112311242
4154447211557542213656323534765147143
2733333273313332323123334333352397Families of metallopeptidases not assigned to clans
19133628233034174429583533263212112812242418172439149263231141222826Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Glu, His or Asp
1111221111121111111111111230Water nucleophile; water bound by single zinc ion ligated to His, Glu (within the motif HXXE) and His
1211113121111111111111432121211144Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HXXEH) and Glu
2111211201111111121134111111212261Water nucleophile; water bound by two zinc ions ligated by Lys, Asp, Asp, Asp, Glu
999171716871388999111071110891112810891598101010334Water nucleophile; water bound by two cobalt or manganese ions ligated by Asp, Asp, His, Glu, Glu
181222181714262222211717192022181615221517101615141515161716131123571Water nucleophile; water bound by two zinc ions ligated by His (or Asp), Asp, Glu, Asp (or Glu), His
1012101717161217137121191412121112151112891110810121010111212385Water nucleophile; water bound by two zinc ions ligated by His, His or Asp, Lys or Glu, His, His.
11111121111111111111111111128Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Asp; membrane proteins with intramembrane active site.
412113116121Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motifs HXXXD and HXH)
666675666557556656555595646665755188Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D)
111111111211114Asparagine nucleophile; catalytic residues in the order Asp, Asn in sequence; all self-processing endopeptidases
11Asparagine nucleophile; all self-processing endopeptidases
241111111215Serine or cysteine nucleophile; catalytic residues in the order His, Asp, Ser (or Cys) in sequence; all endopeptidases
182020212019241825192025191921242222232120212323211722252020202122695Threonine, serine or cysteine nucleophile at the N-terminus of mature enzyme
11461187111028789798541012712121276661686537288Serine or cysteine nucleophile; catalytic residues in the order Cys (or Ser), His, Glu in sequence.
11Cysteine nucleophile at the N-terminus of mature enzyme; catalytic residues in the order Cys, Thr, His
1211111211113Serine or threonine nucleophile; N-terminal nucleophile
610141317177191492020171356282230162010103910121220121623166509Serine nucleophile; catalytic residues in the order Asp, His, Ser in sequence in family S8, but family S53 differs
9810510120721418912013417510011214411114113582116142190911417874180122951271551271081131081324,267Serine nucleophile; catalytic residues in the order Ser, Asp, His in sequence
2133335512278766161146852510131539433181Serine nucleophile; catalytic residues in the order Ser, Lys (within the motif SXXK) in sequence
333333353334342334443344412333553109Serine nucleophile; catalytic residues in the order Ser, Lys (or His) in sequence
167Serine nucleophile; catalytic residues in the order Ser, Lys in sequence
1111111111111162111111111111111138Serine nucleophile; catalytic residues in the order Ser, His, Asp in sequence
112Serine nucleophile; catalytic residues in the order Ser, Glu, His
364344443343453444444464444342434127Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane
111111118Families of peptidases of unknown catalytic mechanism not assigned to clans
1111111111111111111111111111111132
15521313991332129131514189131618871313372118151314182322173512651
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1113
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