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Peptidases • Thermomyces lanuginosus SSBP
Annotations/GenomesAspac1Aspbr1Aspcam1Aspfl1Aspfo1Aspfu1Aspfu_A1163_1Aspni_DSM_1Aspni_NRRL3_1Aspni_bvT_1Aspnid1Aspoch1Aspor1Aspste1Aspsy1Aspve1Aspwe1Aspzo1Monpu1Penac1Pench1Pendi1Pengl1Talma1_2Talst1_2Theau1Thelan1TotalAnnotation Description
Merops
3583992663983722742683794043822912294143714074283643142435052952254143463642141499,073
131671512441315154713136618982299123824107329Water nucleophile; water bound by two Asp from monomer or dimer; all endopeptidases, from eukaryote organisms, viruses or virus-like organisms
1111422342121126Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on periplasmic side of cell membrane.
10745101279733965283378417741010876264Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on cytoplasmic side of cell membrane.
313324293550513337351019344020193835334533284130312719860Cysteine nucleophile; catalytic residues in the order Cys, His, Asn (or Asp) in sequence
33333333433433332335232463386Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
211111111221112111121127Cysteine nucleophile; catalytic residues in the order His, Glu (or Asp), Cys in sequence
111111111111111111111122Cysteine nucleophile; catalytic residues in the order Glu, Cys, His in sequence
112Cysteine nucleophile; active peptidase is a homodimer with active site His and Glu from one monomer and Cys from the other. Catalytic residues in the order His, Glu, Cys in each monomer.
11111117Cysteine nucleophile; catalytic residues in the order Cys, His, His in sequence
6522622455433232332104369822108Water nucleophile; water bound by Gln and Glu; all endopeptidases
112Water nucleophile; water bound by Glu; all self-cleaving endopeptidases
557557755555454496555455455141Families of peptidase inhibitors not assigned to clans
111115
1113
211111119
11
112
112
11111221113122322332136
641242244421143322732247278
112
101011169131377778142091356283355335222Families of metallopeptidases not assigned to clans
1014132414131315151416112512221919131012108141211116376Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Glu, His or Asp
111211111122111111111111128Water nucleophile; water bound by single zinc ion ligated to His, Glu (within the motif HXXE) and His
111111111110Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HXXEH) and Glu
1113Water nucleophile; water bound by two zinc ions ligated by Lys, Asp, Asp, Asp, Glu
8910784481075377676471098710766190Water nucleophile; water bound by two cobalt or manganese ions ligated by Asp, Asp, His, Glu, Glu
28271726251716342830401926303841251619252519291315126646Water nucleophile; water bound by two zinc ions ligated by His (or Asp), Asp, Glu, Asp (or Glu), His
112091116761416158513141216813101811611111184304Water nucleophile; water bound by two zinc ions ligated by His, His or Asp, Lys or Glu, His, His.
1113Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Asp; membrane proteins with intramembrane active site.
11Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motifs HXXXD and HXH)
45325345551213223133424332383Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D)
111111111111111116Water nucleophile; water bound by single zinc ion ligated to Asp, His and His.
11Asparagine nucleophile; catalytic residues in the order Asn, Glu in sequence; all self-processing endopeptidases
142223244221130Serine or cysteine nucleophile; catalytic residues in the order His, Asp, Ser (or Cys) in sequence; all endopeptidases
221921232020192120201716262019192020201920181921252218544Threonine, serine or cysteine nucleophile at the N-terminus of mature enzyme
566876799942986996513851181032190Serine or cysteine nucleophile; catalytic residues in the order Cys (or Ser), His, Glu in sequence.
1113Cysteine nucleophile at the N-terminus of mature enzyme; catalytic residues in the order Cys, Thr, His
11111221112112220Serine or threonine nucleophile; N-terminal nucleophile
112Families of serine peptidases not assigned to clans
101159118713131244965499913759111453225Serine nucleophile; catalytic residues in the order Asp, His, Ser in sequence in family S8, but family S53 differs
138168741521495957147164155616815313114014112612165218926717411012958343,151Serine nucleophile; catalytic residues in the order Ser, Asp, His in sequence
61010124118119127106810581710497133192Serine nucleophile; catalytic residues in the order Ser, Lys (within the motif SXXK) in sequence
43533332221474555234524332291Serine nucleophile; catalytic residues in the order Ser, Lys (or His) in sequence
22222542222232332222222321161Serine nucleophile; catalytic residues in the order Ser, His, Asp in sequence
1121117Serine nucleophile; catalytic residues in the order Ser, Glu, His
21211112212111111212112122238Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane
2272223223943223111457Families of peptidases of unknown catalytic mechanism not assigned to clans
11111111111111111111111121128
910911101191210108919121010111191210812111396281
1225
111115
111111241114
3265118183819373338105343361152234