Peptidases • Vararia minispora EC-137 v1.0
Annotations/GenomesAurvu1Clapy1Densp1Hetan2Lenvul1Lopni1Ricme1Stehi1Varmin1TotalAnnotation Description
Merops
3883724003043294184404143383,403
563784343342513630403Water nucleophile; water bound by two Asp from monomer or dimer; all endopeptidases, from eukaryote organisms, viruses or virus-like organisms
11112212112Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on cytoplasmic side of cell membrane.
161221181025242420170Cysteine nucleophile; catalytic residues in the order Cys, His, Asn (or Asp) in sequence
875791510102596Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
11251341220Cysteine nucleophile; catalytic residues in the order His, Glu (or Asp), Cys in sequence
11Cysteine nucleophile; catalytic residues in the order Glu, Cys, His in sequence
8412776347Water nucleophile; water bound by Gln and Glu; all endopeptidases
23222333222Families of peptidase inhibitors not assigned to clans
11
11114
11111112110
77448458754
22233117223Families of metallopeptidases not assigned to clans
221813131715191215144Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Glu, His or Asp
112Water nucleophile; water bound by single zinc ion ligated to His, Glu (within the motif HXXE) and His
1111111119Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HXXEH) and Glu
111111118Water nucleophile; water bound by two zinc ions ligated by Lys, Asp, Asp, Asp, Glu
778981211141187Water nucleophile; water bound by two cobalt or manganese ions ligated by Asp, Asp, His, Glu, Glu
141613131322252713156Water nucleophile; water bound by two zinc ions ligated by His (or Asp), Asp, Glu, Asp (or Glu), His
9910141013131510103Water nucleophile; water bound by two zinc ions ligated by His, His or Asp, Lys or Glu, His, His.
12111111110Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Asp; membrane proteins with intramembrane active site.
11Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motifs HXXXD and HXH)
75555656650Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D)
112Asparagine nucleophile; catalytic residues in the order Asp, Asn in sequence; all self-processing endopeptidases
11114Serine or cysteine nucleophile; catalytic residues in the order His, Asp, Ser (or Cys) in sequence; all endopeptidases
252020222021242120193Threonine, serine or cysteine nucleophile at the N-terminus of mature enzyme
874448115455Serine or cysteine nucleophile; catalytic residues in the order Cys (or Ser), His, Glu in sequence.
22Serine or threonine nucleophile; N-terminal nucleophile
363242192118171914218Serine nucleophile; catalytic residues in the order Asp, His, Ser in sequence in family S8, but family S53 differs
121146126961171571621461201,191Serine nucleophile; catalytic residues in the order Ser, Asp, His in sequence
273237710243Serine nucleophile; catalytic residues in the order Ser, Lys (within the motif SXXK) in sequence
44332343329Serine nucleophile; catalytic residues in the order Ser, Lys (or His) in sequence
11111111210Serine nucleophile; catalytic residues in the order Ser, His, Asp in sequence
11Serine nucleophile; catalytic residues in the order His, Ser within the motif HXS.
35854234438Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane
112Families of peptidases of unknown catalytic mechanism not assigned to clans
1111111119
191416161722232315165
1113
2215