Peptidases • Botryosphaeriales
Annotations/GenomesAplpr1Botdo1_1Dipse1Macph1Macpha1Meltu1Microd1Neopa1Pcapi1Pcit11120Pcit120373Pcit122482Pcit122670Pcit131864Pcit141352Pcit16586Pcitr2Pcitri2Phcap1Phcapi1Phcapit2Phcit1Phcitr1Phy27169Phycap1Phycapi2Phycit1Phycitr1Phycpc1Sacpr1TotalAnnotation Description
Merops
2943943054054723063613632612562622602632632562602662612632562552712642542662562552652672908,670
252620232420142018151515161715161615181817151517171715171429539Water nucleophile; water bound by two Asp from monomer or dimer; all endopeptidases, from eukaryote organisms, viruses or virus-like organisms
211116Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on periplasmic side of cell membrane.
5849106855344434444556534663446151Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on cytoplasmic side of cell membrane.
11Water nucleophile; water bound by two Asp
222526222724302724222422232323212323232323252323252322232626716Cysteine nucleophile; catalytic residues in the order Cys, His, Asn (or Asp) in sequence
21322242242333232322222232232372Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
21111211112222221211123111211244Cysteine nucleophile; catalytic residues in the order His, Glu (or Asp), Cys in sequence
111111111111111111119Cysteine nucleophile; catalytic residues in the order Glu, Cys, His in sequence
123Cysteine nucleophile; catalytic residues in the order Cys, His, His in sequence
1112111111111115Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
32232321133333333311145311233374Water nucleophile; water bound by Gln and Glu; all endopeptidases
534354544555555555443545445554134Families of peptidase inhibitors not assigned to clans
112
11111111111111111111111225
12115111111111111111111129
112
56268493322222222233222233223394Families of metallopeptidases not assigned to clans
9251525281014181314141616141514141614131115121415131215138445Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Glu, His or Asp
22253134111111111111111111111144Water nucleophile; water bound by single zinc ion ligated to His, Glu (within the motif HXXE) and His
21232231222222222222222222222260Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HXXEH) and Glu
536857777666666676877766766776190Water nucleophile; water bound by two cobalt or manganese ions ligated by Asp, Asp, His, Glu, Glu
202219242626302819181718181818181917181919171818191918181821597Water nucleophile; water bound by two zinc ions ligated by His (or Asp), Asp, Glu, Asp (or Glu), His
101912172220161491010101010101010109999998910101010340Water nucleophile; water bound by two zinc ions ligated by His, His or Asp, Lys or Glu, His, His.
112Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Asp; membrane proteins with intramembrane active site.
1111111119Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motifs HXXXD and HXH)
33333333333333333333333233333389Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D)
23233212121111111112133Serine or cysteine nucleophile; catalytic residues in the order His, Asp, Ser (or Cys) in sequence; all endopeptidases
241919192121232219191919191817182219201919201918181920191821587Threonine, serine or cysteine nucleophile at the N-terminus of mature enzyme
363893833231232333333333334333105Serine or cysteine nucleophile; catalytic residues in the order Cys (or Ser), His, Glu in sequence.
11Cysteine nucleophile at the N-terminus of mature enzyme; catalytic residues in the order Cys, Thr, His
11132111111111112111111121112136Serine or threonine nucleophile; N-terminal nucleophile
112Families of serine peptidases not assigned to clans
101510131411111377877878777777778778812262Serine nucleophile; catalytic residues in the order Asp, His, Ser in sequence in family S8, but family S53 differs
9917310816921598123146908687888587858587889389919191869189878690983,081Serine nucleophile; catalytic residues in the order Ser, Asp, His in sequence
91191013510124644554533444633443353168Serine nucleophile; catalytic residues in the order Ser, Lys (within the motif SXXK) in sequence
42333333323333333333333333333389Serine nucleophile; catalytic residues in the order Ser, Lys (or His) in sequence
2222112222222222222222222222256Serine nucleophile; catalytic residues in the order Ser, His, Asp in sequence
424544444344443444334442434443111Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane
111111111111121112211125Families of peptidases of unknown catalytic mechanism not assigned to clans
1111111111111111111111111111129
11513811121210991091010101010109881112999101099292
11
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