Peptidases • Mrakia frigida ATCC 22029 v1.0
Annotations/GenomesCrycu1Cryne_H99_1Cryne_JEC21_1Cryvi1Crywi1Diocr1Fibin1Mrafri1Treen1Treme1Trich1Trigue1Triol1TotalAnnotation Description
Merops
2161571551711812831812092331492033022152,655
176668106675133814142Water nucleophile; water bound by two Asp from monomer or dimer; all endopeptidases, from eukaryote organisms, viruses or virus-like organisms
111115Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on periplasmic side of cell membrane.
311442311115330Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on cytoplasmic side of cell membrane.
11Water nucleophile; water bound by two Asp
14141115133312141414121515196Cysteine nucleophile; catalytic residues in the order Cys, His, Asn (or Asp) in sequence
433217533456450Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
11123111112Cysteine nucleophile; catalytic residues in the order His, Glu (or Asp), Cys in sequence
12111118Cysteine nucleophile; catalytic residues in the order Glu, Cys, His in sequence
11Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
112Water nucleophile; water bound by Gln and Glu; all endopeptidases
222224222221227Families of peptidase inhibitors not assigned to clans
112
33
11
322124131132328
11122242224124Families of metallopeptidases not assigned to clans
98101810177159911119143Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Glu, His or Asp
11121111111113Water nucleophile; water bound by single zinc ion ligated to His, Glu (within the motif HXXE) and His
1111111119Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HXXEH) and Glu
211127Water nucleophile; water bound by two zinc ions ligated by Lys, Asp, Asp, Asp, Glu
8887712710889128112Water nucleophile; water bound by two cobalt or manganese ions ligated by Asp, Asp, His, Glu, Glu
1213101210101018209121812166Water nucleophile; water bound by two zinc ions ligated by His (or Asp), Asp, Glu, Asp (or Glu), His
151011813151392010151515169Water nucleophile; water bound by two zinc ions ligated by His, His or Asp, Lys or Glu, His, His.
1111111119Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Asp; membrane proteins with intramembrane active site.
555557565555568Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D)
11Water nucleophile; water bound by single zinc ion ligated to Asp, His and His.
11114Asparagine nucleophile; catalytic residues in the order Asp, Asn in sequence; all self-processing endopeptidases
1111116Serine or cysteine nucleophile; catalytic residues in the order His, Asp, Ser (or Cys) in sequence; all endopeptidases
22171820223221202520212722287Threonine, serine or cysteine nucleophile at the N-terminus of mature enzyme
332325374348350Serine or cysteine nucleophile; catalytic residues in the order Cys (or Ser), His, Glu in sequence.
1124Serine or threonine nucleophile; N-terminal nucleophile
11Families of serine peptidases not assigned to clans
111212131111117Serine nucleophile; catalytic residues in the order Asp, His, Ser in sequence in family S8, but family S53 differs
54404436547352577131518555703Serine nucleophile; catalytic residues in the order Ser, Asp, His in sequence
11231665817201190Serine nucleophile; catalytic residues in the order Ser, Lys (within the motif SXXK) in sequence
332334344333341Serine nucleophile; catalytic residues in the order Ser, Lys (or His) in sequence
111121221111116Serine nucleophile; catalytic residues in the order Ser, His, Asp in sequence
333244422422439Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane
112Families of peptidases of unknown catalytic mechanism not assigned to clans
111111111111113
141010128151113119131113150
1113