Peptidases • Eurotium rubrum v1.0
Annotations/GenomesAspcl1Aspfl1Aspfu1Aspni5Aspnid1Aspor1Aspte1Eurhe1Neofi1Pench1TotalAnnotation Description
Merops
2733982742914143222443092952,820
9154413987978Water nucleophile; water bound by two Asp from monomer or dimer; all endopeptidases, from eukaryote organisms, viruses or virus-like organisms
114219Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on periplasmic side of cell membrane.
451336573771Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on cytoplasmic side of cell membrane.
412950103435315233315Cysteine nucleophile; catalytic residues in the order Cys, His, Asn (or Asp) in sequence
33333333226Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
111211119Cysteine nucleophile; catalytic residues in the order His, Glu (or Asp), Cys in sequence
11111117Cysteine nucleophile; catalytic residues in the order Glu, Cys, His in sequence
112Cysteine nucleophile; active peptidase is a homodimer with active site His and Glu from one monomer and Cys from the other. Catalytic residues in the order His, Glu, Cys in each monomer.
11215Cysteine nucleophile; catalytic residues in the order Cys, His, His in sequence
22243333426Water nucleophile; water bound by Gln and Glu; all endopeptidases
11Water nucleophile; water bound by Glu; all self-cleaving endopeptidases
55754566548Families of peptidase inhibitors not assigned to clans
11
112
11
11
2123111314
3221211315
11
7161371414715396Families of metallopeptidases not assigned to clans
152413162512121710144Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Glu, His or Asp
12121119Water nucleophile; water bound by single zinc ion ligated to His, Glu (within the motif HXXE) and His
11114Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HXXEH) and Glu
112Water nucleophile; water bound by two zinc ions ligated by Lys, Asp, Asp, Asp, Glu
77457948960Water nucleophile; water bound by two cobalt or manganese ions ligated by Asp, Asp, His, Glu, Glu
222617402623162225217Water nucleophile; water bound by two zinc ions ligated by His (or Asp), Asp, Glu, Asp (or Glu), His
511781315861184Water nucleophile; water bound by two zinc ions ligated by His, His or Asp, Lys or Glu, His, His.
112Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Asp; membrane proteins with intramembrane active site.
32311333423Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D)
11114Water nucleophile; water bound by single zinc ion ligated to Asp, His and His.
11Asparagine nucleophile; catalytic residues in the order Asn, Glu in sequence; all self-processing endopeptidases
34232317Serine or cysteine nucleophile; catalytic residues in the order His, Asp, Ser (or Cys) in sequence; all endopeptidases
222320172618202220188Threonine, serine or cysteine nucleophile at the N-terminus of mature enzyme
986494711866Serine or cysteine nucleophile; catalytic residues in the order Cys (or Ser), His, Glu in sequence.
112Cysteine nucleophile at the N-terminus of mature enzyme; catalytic residues in the order Cys, Thr, His
11121129Serine or threonine nucleophile; N-terminal nucleophile
11Families of serine peptidases not assigned to clans
79849668764Serine nucleophile; catalytic residues in the order Asp, His, Ser in sequence in family S8, but family S53 differs
771525961153116708592865Serine nucleophile; catalytic residues in the order Ser, Asp, His in sequence
51211710151052Serine nucleophile; catalytic residues in the order Ser, Lys (within the motif SXXK) in sequence
23317244531Serine nucleophile; catalytic residues in the order Ser, Lys (or His) in sequence
12523212220Serine nucleophile; catalytic residues in the order Ser, His, Asp in sequence
11Serine nucleophile; catalytic residues in the order Ser, Glu, His
21121121112Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane
72391123Families of peptidases of unknown catalytic mechanism not assigned to clans
1111111119
9111181981281096
11
11
1113
518383374381