Peptidases • Pucciniales
Annotations/GenomesCroqu1MecolCla_1Melame1Melap1finSC_191Melli1Mellp2_3Melme_tre1Melmed1Pgt_201_A1Pgt_201_B1Pgt_Ug99_A1Pgt_Ug99_C1Phapa1PuccoNC29_1PuccoSD80_1Pucgr2Pucst1Pucst_PST78_1Pucstr1Puctr1TotalAnnotation Description
Merops
1924202082611782312562591921982032153583383051942242443712085,055
2741242739262528141416152958431314212914517Water nucleophile; water bound by two Asp from monomer or dimer; all endopeptidases, from eukaryote organisms, viruses or virus-like organisms
11112118Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on periplasmic side of cell membrane.
1221111211112222212331Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on cytoplasmic side of cell membrane.
1947253414243125181817131822201322163419449Cysteine nucleophile; catalytic residues in the order Cys, His, Asn (or Asp) in sequence
2517324624342352335369Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
24225311121Cysteine nucleophile; catalytic residues in the order His, Glu (or Asp), Cys in sequence
11111121111222212124Cysteine nucleophile; catalytic residues in the order Glu, Cys, His in sequence
19120Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
3324232224224552225359Families of peptidase inhibitors not assigned to clans
213
11
11
121111112314
211463668555477853478114
22
12111112111Families of metallopeptidases not assigned to clans
5126810997899710131591117178199Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Glu, His or Asp
11128133424Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HXXEH) and Glu
1111112312141612212135Water nucleophile; water bound by two zinc ions ligated by Lys, Asp, Asp, Asp, Glu
6117647895565888579146144Water nucleophile; water bound by two cobalt or manganese ions ligated by Asp, Asp, His, Glu, Glu
71598498881189101813101412239213Water nucleophile; water bound by two zinc ions ligated by His (or Asp), Asp, Glu, Asp (or Glu), His
5135554658599211010899126164Water nucleophile; water bound by two zinc ions ligated by His, His or Asp, Lys or Glu, His, His.
1211111111112221114127Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Asp; membrane proteins with intramembrane active site.
11Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motifs HXXXD and HXH)
5158776886566899557105145Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D)
111115Asparagine nucleophile; catalytic residues in the order Asp, Asn in sequence; all self-processing endopeptidases
1113Serine or cysteine nucleophile; catalytic residues in the order His, Asp, Ser (or Cys) in sequence; all endopeptidases
2337192117172421181820244737291926303922508Threonine, serine or cysteine nucleophile at the N-terminus of mature enzyme
1224121133223221212340Serine or cysteine nucleophile; catalytic residues in the order Cys (or Ser), His, Glu in sequence.
11211219Serine or threonine nucleophile; N-terminal nucleophile
7165958128131313171220201416122112253Serine nucleophile; catalytic residues in the order Asp, His, Ser in sequence in family S8, but family S53 differs
541376388437779886155626490797856526297561,441Serine nucleophile; catalytic residues in the order Ser, Asp, His in sequence
112Serine nucleophile; catalytic residues in the order Ser, Lys (within the motif SXXK) in sequence
3433333314243335224664Serine nucleophile; catalytic residues in the order Ser, Lys (or His) in sequence
11612112Serine nucleophile; catalytic residues in the order Ser, Lys in sequence
12121111221331222129Serine nucleophile; catalytic residues in the order Ser, His, Asp in sequence
232111211112133111230Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane
11Families of peptidases of unknown catalytic mechanism not assigned to clans
121111112121112120
112815129151317121512173020191618152618338
33
11