Peptidases • Meredithblackwellia eburnea MCA 4105 v1.0
Annotations/GenomesAgahy1Croqu1Hetpy1Mellp1Mereb1Mixos1Pucgr1Rhosp1Schco3Trisp1TotalAnnotation Description
Merops
1781921722911831653451741,700
11271230309297155Water nucleophile; water bound by two Asp from monomer or dimer; all endopeptidases, from eukaryote organisms, viruses or virus-like organisms
2112122112Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on cytoplasmic side of cell membrane.
2019221911152017143Cysteine nucleophile; catalytic residues in the order Cys, His, Asn (or Asp) in sequence
3233225222Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
12126Cysteine nucleophile; catalytic residues in the order His, Glu (or Asp), Cys in sequence
111115Cysteine nucleophile; catalytic residues in the order Glu, Cys, His in sequence
11Water nucleophile; water bound by Gln and Glu; all endopeptidases
3323222320Families of peptidase inhibitors not assigned to clans
1113
1124
2226127123
1111113110Families of metallopeptidases not assigned to clans
10561077221683Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Glu, His or Asp
212229Water nucleophile; water bound by single zinc ion ligated to His, Glu (within the motif HXXE) and His
11215Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HXXEH) and Glu
11112129Water nucleophile; water bound by two zinc ions ligated by Lys, Asp, Asp, Asp, Glu
66784710553Water nucleophile; water bound by two cobalt or manganese ions ligated by Asp, Asp, His, Glu, Glu
878136923579Water nucleophile; water bound by two zinc ions ligated by His (or Asp), Asp, Glu, Asp (or Glu), His
5561351012561Water nucleophile; water bound by two zinc ions ligated by His, His or Asp, Lys or Glu, His, His.
11111117Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Asp; membrane proteins with intramembrane active site.
6545455539Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D)
1113Asparagine nucleophile; catalytic residues in the order Asp, Asn in sequence; all self-processing endopeptidases
11Asparagine nucleophile; all self-processing endopeptidases
11Serine or cysteine nucleophile; catalytic residues in the order His, Asp, Ser (or Cys) in sequence; all endopeptidases
1923182417172217157Threonine, serine or cysteine nucleophile at the N-terminus of mature enzyme
3124327123Serine or cysteine nucleophile; catalytic residues in the order Cys (or Ser), His, Glu in sequence.
112Serine or threonine nucleophile; N-terminal nucleophile
27328161342Serine nucleophile; catalytic residues in the order Asp, His, Ser in sequence in family S8, but family S53 differs
465444105604213243526Serine nucleophile; catalytic residues in the order Ser, Asp, His in sequence
22843524Serine nucleophile; catalytic residues in the order Ser, Lys (within the motif SXXK) in sequence
3334233425Serine nucleophile; catalytic residues in the order Ser, Lys (or His) in sequence
112121210Serine nucleophile; catalytic residues in the order Ser, His, Asp in sequence
3224434224Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane
111111118
12111313914121195
11
213
1236