Peptidases • Polyporales
Annotations/GenomesAbobi1Abobie1Amylap1_1Antser1Antsi1Artel1Artele1122_1Bjead1_1Cersu1Cerun2Cervir1Clibor1Cytmel1Daequ1Dicsq1Dicsqu18370_1Dicsqu463_1Dicsqu464_1Earsca1Epityp1Fibra1Flafl1Fomfom1Fompi3Fomro1Fomros1Gansp1Hexnit1Hydfim1Irplac1Laesu1Leisp1Lenti6_1Lenti7_1Lepmol1Mersum1Obbri1Panru1Phaca1Phchr2Phlbr1Phlcen1Phlgi1Phlrad1Pipbet1_1Polar1Polbr1Polsqu1Pospl1PosplRSB12_1Possti1Pycci1Pyccin1Pycco1Pycco1662_1Pycpun1Pycsa1Rigmic1Sisbr1Spalat1Trabet1Trace1Traci1Tragib1Tralac1Tralj1Tramax1Tramen1Tramey1Trapol1Trapub1Trave1Wolco1TotalAnnotation Description
Merops
33133029641130537735340234033936331927931940739639138642541927932541233834333538042229937433341242643131828535631645035445032036833628644344742719633436031734136736430137627842128834930734433838835235940036334241143332126,103
394352493663395841415947355344474649456035483839434048513952396044486232504369626556414635525947204748464454493754254745423544435149465444495662403,420Water nucleophile; water bound by two Asp from monomer or dimer; all endopeptidases, from eukaryote organisms, viruses or virus-like organisms
11Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on periplasmic side of cell membrane.
1114222211222211112211241121212211212212222232212212222223111211112211111119Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on cytoplasmic side of cell membrane.
12131217181415161312131217131620191814141720181414131515192212141010131214141716181212161214121581312111114121111181013111511131111121214131415161,020Cysteine nucleophile; catalytic residues in the order Cys, His, Asn (or Asp) in sequence
6522159715710365967673644610595478224545854731777955746645333545464645345344448447Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
22131112211133321211121121115211112121211221122277Cysteine nucleophile; catalytic residues in the order His, Glu (or Asp), Cys in sequence
11Cysteine nucleophile: catalytic residues in the order Cys, His in sequence
11114Cysteine nucleophile; catalytic residues in the order Cys, His, His in sequence
314Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
4111113333332263383611333411152445511223234221221151211223Water nucleophile; water bound by Gln and Glu; all endopeptidases
121723122921366322222421103222102692233582104515710423332222222222322612223222222287Families of peptidase inhibitors not assigned to clans
1258
11114
11
1111111111111111111111111111111111111111111111111111111111111162
5421322436553332235132121234313323433248244333212222222631252222323212195
334542232323342222323223652222723313213311243324542222223352222222222224193Families of metallopeptidases not assigned to clans
14141212101716179172214141015151615221611152311981421161713162422121313141592011141310161817111416141616181418122013151717151617221827192722111,137Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Glu, His or Asp
11111111211111111111111111111111111111111121111111111111111111111111171Water nucleophile; water bound by single zinc ion ligated to His, Glu (within the motif HXXE) and His
1111111111121111111111111111111361111115211111111111121311111111121387Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HXXEH) and Glu
1211111212111111121111111111121121111111349Water nucleophile; water bound by two zinc ions ligated by Lys, Asp, Asp, Asp, Glu
10108810988998797881099959107778991189889811118911789991094107119101081198108910910810887999637Water nucleophile; water bound by two cobalt or manganese ions ligated by Asp, Asp, His, Glu, Glu
16151313141515201315181615131312161318121414181616151316141413161514141211201415151315171316161731320171614171714181413171217221617141414181615171,096Water nucleophile; water bound by two zinc ions ligated by His (or Asp), Asp, Glu, Asp (or Glu), His
12121116121011101110101091015151515141511121111131311119161311111111119121110111113111211111481114121211119119121412101211111110111012171212850Water nucleophile; water bound by two zinc ions ligated by His, His or Asp, Lys or Glu, His, His.
1111111111121111111111111111111111111111111111111111111111111111166Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Asp; membrane proteins with intramembrane active site.
111111112111111111111111126Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motifs HXXXD and HXH)
5556556665555566665555655566569556555666656555671755566666556567656565476402Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D)
111111111111111116Asparagine nucleophile; catalytic residues in the order Asp, Asn in sequence; all self-processing endopeptidases
21115Serine or cysteine nucleophile; catalytic residues in the order His, Asp, Ser (or Cys) in sequence; all endopeptidases
22221922232423211723232223222225242421241823252221212221232623222322232222231922232121222122222282024182322222322192221242222212223222122222322241,597Threonine, serine or cysteine nucleophile at the N-terminus of mature enzyme
665574576655647764108365455655645776758666987310963564555558756644554545655415Serine or cysteine nucleophile; catalytic residues in the order Cys (or Ser), His, Glu in sequence.
1113Serine or threonine nucleophile; N-terminal nucleophile
871835222222524111614112132333233393715143828263125371414143439391515211117123110191220303132102332252527261829113918221324223125263129232834201,697Serine nucleophile; catalytic residues in the order Asp, His, Ser in sequence in family S8, but family S53 differs
1321229714497149150152136125125107931091361521461471681671051061641161331251281739713411415918017810298142105147127160121131129991841871727511312811713414714410614594180841401051351321551421391601361281651781059,757Serine nucleophile; catalytic residues in the order Ser, Asp, His in sequence
5524343722371355546744563436441755335423843131174548543444636422444854561310Serine nucleophile; catalytic residues in the order Ser, Lys (within the motif SXXK) in sequence
3343433332222344444433533346232344313322323334446523333254433243434433344239Serine nucleophile; catalytic residues in the order Ser, Lys (or His) in sequence
11Serine nucleophile; catalytic residues in the order Ser, Lys in sequence
11121112112111111111111111111111111111111111111111111111111111111111172Serine nucleophile; catalytic residues in the order Ser, His, Asp in sequence
2255323432464555542434444443445344436414413344444462333444344434444233233265Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane
11111111111111111111211125Families of peptidases of unknown catalytic mechanism not assigned to clans
11111111111111111111111111111111111111111111111111111111111111111111111172
911141816109252114914111052151616191213111716121135161113161418211111191053141413171211272028111799111213131414141410191189812111591513221,118
11114
113117
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