Peptidases • Lichens
Annotations/GenomesAstpho2Clagr3Dicre1EndpusZ1Lobpul1LobpulAf1LobpulSc1LobpulSp1LobpulSw1Sclsan1SymretAf1SymretSc1SymretSp1SymretSw1TrebA12_1Tryvi1Usnflo1Xanpa2TotalAnnotation Description
Merops
2722313062103043033002992921652982943052812573562712595,003
418111230383334346991192192018317Water nucleophile; water bound by two Asp from monomer or dimer; all endopeptidases, from eukaryote organisms, viruses or virus-like organisms
36462121124443338562Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on cytoplasmic side of cell membrane.
11114Water nucleophile; water bound by two Asp
252124192524262524222523292523262424434Cysteine nucleophile; catalytic residues in the order Cys, His, Asn (or Asp) in sequence
34613233226767343267Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
31211111213233111129Cysteine nucleophile; catalytic residues in the order His, Glu (or Asp), Cys in sequence
1111111111111111117Cysteine nucleophile; catalytic residues in the order Glu, Cys, His in sequence
1111111119Cysteine nucleophile; catalytic residues in the order Cys, His, His in sequence
2131111122222211126Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
2121114113Water nucleophile; water bound by Gln and Glu; all endopeptidases
54544444465555455583Families of peptidase inhibitors not assigned to clans
1111116
11
11
111115
1111111119
122332222222265240
35241299109211223107192Families of metallopeptidases not assigned to clans
116151815161618157141514151312815243Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Glu, His or Asp
51312222212332421240Water nucleophile; water bound by single zinc ion ligated to His, Glu (within the motif HXXE) and His
32622222223433312246Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HXXEH) and Glu
11111117Water nucleophile; water bound by two zinc ions ligated by Lys, Asp, Asp, Asp, Glu
6688676665888810867127Water nucleophile; water bound by two cobalt or manganese ions ligated by Asp, Asp, His, Glu, Glu
13141212151714141410121312118151418238Water nucleophile; water bound by two zinc ions ligated by His (or Asp), Asp, Glu, Asp (or Glu), His
651141212121012311111211111234162Water nucleophile; water bound by two zinc ions ligated by His, His or Asp, Lys or Glu, His, His.
521111314Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Asp; membrane proteins with intramembrane active site.
1113Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motifs HXXXD and HXH)
83433333334544433366Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D)
1111116Asparagine nucleophile; catalytic residues in the order Asp, Asn in sequence; all self-processing endopeptidases
48111111999742159Serine or cysteine nucleophile; catalytic residues in the order His, Asp, Ser (or Cys) in sequence; all endopeptidases
282121182119201919192521242120242223385Threonine, serine or cysteine nucleophile at the N-terminus of mature enzyme
1116421111276761033375Serine or cysteine nucleophile; catalytic residues in the order Cys (or Ser), His, Glu in sequence.
4786631Cysteine nucleophile at the N-terminus of mature enzyme; catalytic residues in the order Cys, Thr, His
11111117Serine or threonine nucleophile; N-terminal nucleophile
897212121513125666642686163Serine nucleophile; catalytic residues in the order Asp, His, Ser in sequence in family S8, but family S53 differs
74688966949293939137858484808413897841,533Serine nucleophile; catalytic residues in the order Ser, Asp, His in sequence
16456556221163558Serine nucleophile; catalytic residues in the order Ser, Lys (within the motif SXXK) in sequence
43623334335765535373Serine nucleophile; catalytic residues in the order Ser, Lys (or His) in sequence
11114Serine nucleophile; catalytic residues in the order His, Ser, His in sequence
11111117Serine nucleophile; catalytic residues in the order Ser, Lys in sequence
1721942222211815191613122139Serine nucleophile; catalytic residues in the order Ser, His, Asp in sequence
1113Serine nucleophile; catalytic residues in the order His, Ser within the motif HXS.
11Serine nucleophile; catalytic residues in the order Ser, Glu, His
83821221228877833479Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane
1111111111111
4107716151314131464635111212172
11
11
524345423234