Peptidases • Aspergillus
Annotations/GenomesAspac1Aspacri1Aspacu1Aspalbe1Aspamy1Aspara19utrAspave1Aspber1Aspbisp1Aspbom1Aspbr1Aspbrev1Aspbru1Aspca3Aspcae1Aspcal1Aspcam1Aspcand1Aspcar1Aspchev1Aspcl1Aspcor1Aspcos1Aspcri1Aspdese1Aspegy1Aspell1Aspeuc1Aspfij1Aspfili1Aspfl1Aspfo1Aspfu1Aspfu_A1163_1Aspfuni1Aspgl1Asphet1Asphom1Aspibe1Aspind1Aspind2_1Aspinso1Aspjap1Aspka1_1Asplac1Aspmin1Aspmul1_1Aspne1Aspneo1Aspneoa1Aspni7Aspni_DSM_1Aspni_NRRL3_1Aspni_bvT_1Aspnid1Aspnom1Aspnom13137_1Aspnov1Aspnovo1Aspoch1Aspoch1432_1Aspoli1_1Aspor1Asppar1Aspparv1Asppeni1Aspph1Asppip1Asppsec1Asppsen1Asppset1Aspram1Asprec1_1Aspres1Asprobu1Aspros1Aspsac1Aspsc1Aspscl1Aspscle1Aspser1Aspste1Aspstec1_1Aspstel1_1Aspsy1Asptaic1Asptam1Aspte1Asptr1Asptra1Asptu1Aspuda1Aspund1_1Aspung1Aspuva1Aspvad1Aspve1Aspven1Aspvio1Aspwe1Aspwel1Eurhe1Neofi1TotalAnnotation Description
Merops
35835841139935140947526627336725435836335339837227426827330131735935035135937835838837940438229139432222922241437536321629238339537140732237331535235642834736424430918,990
13141216131797913915151415124481410161413111514151315154137771315136121617136912814136131887641Water nucleophile; water bound by two Asp from monomer or dimer; all endopeptidases, from eukaryote organisms, viruses or virus-like organisms
11115111111114122221314140Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on periplasmic side of cell membrane.
10106788284477897510128981086899879733429967811599528510378336773481Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on cytoplasmic side of cell membrane.
11Water nucleophile; water bound by two Asp
313334333438232441323431353529355051352631303334373135343337351031511918343333173031344020353349313719343831521,814Cysteine nucleophile; catalytic residues in the order Cys, His, Asn (or Asp) in sequence
3333333333323333333322343333343333443333233333334334233166Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
2221231111212111111121111111212113121112211160Cysteine nucleophile; catalytic residues in the order His, Glu (or Asp), Cys in sequence
1111111111111111111111111111111111111111111111147Cysteine nucleophile; catalytic residues in the order Glu, Cys, His in sequence
112Cysteine nucleophile; active peptidase is a homodimer with active site His and Glu from one monomer and Cys from the other. Catalytic residues in the order His, Glu, Cys in each monomer.
11111111121113Cysteine nucleophile; catalytic residues in the order Cys, His, His in sequence
11Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
6645662226476626224778676565455432333563576233636626333251Water nucleophile; water bound by Gln and Glu; all endopeptidases
112Water nucleophile; water bound by Glu; all self-cleaving endopeptidases
5545556755655555777455555555555546554553555545565545966285Families of peptidase inhibitors not assigned to clans
1111212110
111121111111
21112119
11
112
11111212111111122211111111111131111111111221113121163
642444513533442422223557446444422211542364142515435311183
112
10151410146151178669151691313771151211767777771318861478577520914101311913115715540Families of metallopeptidases not assigned to clans
109231491823131515111613122414131312101616121214151314151514162115111525151312111818122212151214121914191217813Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Glu, His or Asp
1121112111111211111111111111211121111112111111111156Water nucleophile; water bound by single zinc ion ligated to His, Glu (within the motif HXXE) and His
11111111111111111118Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HXXEH) and Glu
111115Water nucleophile; water bound by two zinc ions ligated by Lys, Asp, Asp, Asp, Glu
8879711610786789784466678797988107596357885799769867877648396Water nucleophile; water bound by two cobalt or manganese ions ligated by Asp, Asp, His, Glu, Glu
282826272524391722241822222626251716152024222626223022263428304029251917262924182323243038232525262241252516221,372Water nucleophile; water bound by two zinc ions ligated by His (or Asp), Asp, Glu, Asp (or Glu), His
1111142011141495148151411111676101271399151613171416158128551315164715151412151591015169886637Water nucleophile; water bound by two zinc ions ligated by His, His or Asp, Lys or Glu, His, His.
1113Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Asp; membrane proteins with intramembrane active site.
1113Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motifs HXXXD and HXH)
4415443335345425343344555555555114221552344323545525333202Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D)
111112111111111111111111111111111111138Water nucleophile; water bound by single zinc ion ligated to Asp, His and His.
11Asparagine nucleophile; catalytic residues in the order Asn, Glu in sequence; all self-processing endopeptidases
4141311422211243224414356Serine or cysteine nucleophile; catalytic residues in the order His, Asp, Ser (or Cys) in sequence; all endopeptidases
222122192023202122202418192023202019212022182121202019202120201722221615261919172318222019181822211919202020221,110Threonine, serine or cysteine nucleophile at the N-terminus of mature enzyme
561165116698556587675589546968999410722997281098649966959711382Serine or cysteine nucleophile; catalytic residues in the order Cys (or Ser), His, Glu in sequence.
11111117Cysteine nucleophile at the N-terminus of mature enzyme; catalytic residues in the order Cys, Thr, His
1221111121111111121212221111238Serine or threonine nucleophile; N-terminal nucleophile
112Families of serine peptidases not assigned to clans
10139111211857106910119118767101199101210121313124874591310581411656971010411968490Serine nucleophile; catalytic residues in the order Asp, His, Ser in sequence in family S8, but family S53 differs
13812815916813216617474771506814514712415214959578011310914913413414815514116014716415561149946860153153149601041541701311401161509213514614113112670856,894Serine nucleophile; catalytic residues in the order Ser, Asp, His in sequence
661510661110573556124114775574981081191146217752365106107965861015355Serine nucleophile; catalytic residues in the order Ser, Lys (within the motif SXXK) in sequence
4463423522432333333242342233222141447224233452325254544175Serine nucleophile; catalytic residues in the order Ser, Lys (or His) in sequence
2232223212122222541112112222222232223222121232222231212110Serine nucleophile; catalytic residues in the order Ser, His, Asp in sequence
111111111121111111111111111129Serine nucleophile; catalytic residues in the order Ser, Glu, His
221123122121121111212122211122122211111111111112111112176Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane
1722423112272222122233223692221431312212103Families of peptidases of unknown catalytic mechanism not assigned to clans
111111111111111111111111111111111111111111111111111111155
91181091312991110161211111011916108109101081191210108111391019810971211121081011910101011128572
21227
11114
111111118
333233466135118187241331383519203183117333423821074348