Peptidases • Gymnopus earleae GB-263.02 v1.0
Annotations/GenomesDenbi1Gyman1Gymear1Gymlu1Ompol1Rhobut1_1TotalAnnotation Description
Merops
6996154905612514613,077
615641552029262Water nucleophile; water bound by two Asp from monomer or dimer; all endopeptidases, from eukaryote organisms, viruses or virus-like organisms
32131212Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on cytoplasmic side of cell membrane.
373024231821153Cysteine nucleophile; catalytic residues in the order Cys, His, Asn (or Asp) in sequence
13861162771Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
7845630Cysteine nucleophile; catalytic residues in the order His, Glu (or Asp), Cys in sequence
11Cysteine nucleophile: catalytic residues in the order Cys, His in sequence
11011121843Water nucleophile; water bound by Gln and Glu; all endopeptidases
10623121759Families of peptidase inhibitors not assigned to clans
11
1113
111115
168463744
3343518Families of metallopeptidases not assigned to clans
20171512141391Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Glu, His or Asp
1113Water nucleophile; water bound by single zinc ion ligated to His, Glu (within the motif HXXE) and His
2411210Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HXXEH) and Glu
37221520Water nucleophile; water bound by two zinc ions ligated by Lys, Asp, Asp, Asp, Glu
1213101081568Water nucleophile; water bound by two cobalt or manganese ions ligated by Asp, Asp, His, Glu, Glu
432724221522153Water nucleophile; water bound by two zinc ions ligated by His (or Asp), Asp, Glu, Asp (or Glu), His
32141515816100Water nucleophile; water bound by two zinc ions ligated by His, His or Asp, Lys or Glu, His, His.
111115Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Asp; membrane proteins with intramembrane active site.
216312Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motifs HXXXD and HXH)
77554634Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D)
22Serine or cysteine nucleophile; catalytic residues in the order His, Asp, Ser (or Cys) in sequence; all endopeptidases
332525231725148Threonine, serine or cysteine nucleophile at the N-terminus of mature enzyme
2211121261073Serine or cysteine nucleophile; catalytic residues in the order Cys (or Ser), His, Glu in sequence.
134427301230156Serine nucleophile; catalytic residues in the order Asp, His, Ser in sequence in family S8, but family S53 differs
261238182190951581,124Serine nucleophile; catalytic residues in the order Ser, Asp, His in sequence
19141541760Serine nucleophile; catalytic residues in the order Ser, Lys (within the motif SXXK) in sequence
62341420Serine nucleophile; catalytic residues in the order Ser, Lys (or His) in sequence
111115Serine nucleophile; catalytic residues in the order Ser, His, Asp in sequence
11Serine nucleophile; catalytic residues in the order His, Ser within the motif HXS.
45444324Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane
112Families of peptidases of unknown catalytic mechanism not assigned to clans
111115
644823871324259