Peptidases • Rutstroemia firma CBS 115.86 v1.0
Annotations/GenomesAmore1Cadsp1Chalo1Lorju1Melbi2Oidma1Phisc1Rhier1Rutfi1TotalAnnotation Description
Merops
2567256724124956226484193424,591
153150352736413216283Water nucleophile; water bound by two Asp from monomer or dimer; all endopeptidases, from eukaryote organisms, viruses or virus-like organisms
1113Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on periplasmic side of cell membrane.
71716913111775102Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on cytoplasmic side of cell membrane.
203729213533263024255Cysteine nucleophile; catalytic residues in the order Cys, His, Asn (or Asp) in sequence
43545445236Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
11352123119Cysteine nucleophile; catalytic residues in the order His, Glu (or Asp), Cys in sequence
15311131218Cysteine nucleophile; catalytic residues in the order Glu, Cys, His in sequence
1113Cysteine nucleophile; catalytic residues in the order Cys, His, His in sequence
11111117Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
2418561387568Water nucleophile; water bound by Gln and Glu; all endopeptidases
112Water nucleophile; water bound by Glu; all self-cleaving endopeptidases
55455554442Families of peptidase inhibitors not assigned to clans
112
11215
22
22
2112112212
37753652341
11
410867873356Families of metallopeptidases not assigned to clans
93323151715211211156Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Glu, His or Asp
12111111211Water nucleophile; water bound by single zinc ion ligated to His, Glu (within the motif HXXE) and His
11212112112Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HXXEH) and Glu
8111091010129887Water nucleophile; water bound by two cobalt or manganese ions ligated by Asp, Asp, His, Glu, Glu
184138272730412023265Water nucleophile; water bound by two zinc ions ligated by His (or Asp), Asp, Glu, Asp (or Glu), His
112523101818261111153Water nucleophile; water bound by two zinc ions ligated by His, His or Asp, Lys or Glu, His, His.
11Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motifs HXXXD and HXH)
44444444436Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D)
11111117Water nucleophile; water bound by single zinc ion ligated to Asp, His and His.
7424232226Serine or cysteine nucleophile; catalytic residues in the order His, Asp, Ser (or Cys) in sequence; all endopeptidases
222727262429262520226Threonine, serine or cysteine nucleophile at the N-terminus of mature enzyme
2131165864459Serine or cysteine nucleophile; catalytic residues in the order Cys (or Ser), His, Glu in sequence.
2112211111Serine or threonine nucleophile; N-terminal nucleophile
112Families of serine peptidases not assigned to clans
134035222538342514246Serine nucleophile; catalytic residues in the order Asp, His, Ser in sequence in family S8, but family S53 differs
753152901471842742951601441,884Serine nucleophile; catalytic residues in the order Ser, Asp, His in sequence
4302115222623139163Serine nucleophile; catalytic residues in the order Ser, Lys (within the motif SXXK) in sequence
33333333327Serine nucleophile; catalytic residues in the order Ser, Lys (or His) in sequence
11212312114Serine nucleophile; catalytic residues in the order Ser, His, Asp in sequence
12115Serine nucleophile; catalytic residues in the order Ser, Glu, His
33536223330Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane
112Families of peptidases of unknown catalytic mechanism not assigned to clans
1111111119
123014132324151712160
211217
24634562133