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Peptidases • Metschnikowia fructicola 277
Annotations/GenomesArtfe1_2Babin1Canar1Cepfr1_1Clalu1_2Debha1Dekbr2Hanpo2Hanva1_1Hypbu1Klula1Metbi1Metfru2Nadfu1Pacta1_2Picme2Picpa1Sacce1SacceM3837_1SacceM3838_1SacceYB210_1Tripe1Wican1Yarli1Zyghe1_2TotalAnnotation Description
Merops
1601711411641531511431511111531271422581591521341281371371361431901822121843,919
311212172066561051225610610899819123514313Water nucleophile; water bound by two Asp from monomer or dimer; all endopeptidases, from eukaryote organisms, viruses or virus-like organisms
12115Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on periplasmic side of cell membrane.
111111111111121218Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on cytoplasmic side of cell membrane.
15171214111315141115131417161313111515151717181418363Cysteine nucleophile; catalytic residues in the order Cys, His, Asn (or Asp) in sequence
342422333422232222222342264Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
121111211112Cysteine nucleophile; catalytic residues in the order His, Glu (or Asp), Cys in sequence
11Cysteine nucleophile; catalytic residues in the order Glu, Cys, His in sequence
11Cysteine nucleophile; catalytic residues in the order Cys, His, His in sequence
11111111111112Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
1214Water nucleophile; water bound by Gln and Glu; all endopeptidases
243343342324754242222443381Families of peptidase inhibitors not assigned to clans
11114
1113
11114
111111213112222212229
222222223222222223331242255
111111111112111111111123Families of metallopeptidases not assigned to clans
61386105666117616776677771261013201Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Glu, His or Asp
11111111111111111111211125Water nucleophile; water bound by single zinc ion ligated to His, Glu (within the motif HXXE) and His
12211112311195121112312146Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HXXEH) and Glu
77688778664712768655557677167Water nucleophile; water bound by two cobalt or manganese ions ligated by Asp, Asp, His, Glu, Glu
111410181014141311121311161514118910101013191319318Water nucleophile; water bound by two zinc ions ligated by His (or Asp), Asp, Glu, Asp (or Glu), His
3464449924546497344454647125Water nucleophile; water bound by two zinc ions ligated by His, His or Asp, Lys or Glu, His, His.
11Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motifs HXXXD and HXH)
22442343313344522222534372Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D)
21115Serine or cysteine nucleophile; catalytic residues in the order His, Asp, Ser (or Cys) in sequence; all endopeptidases
17161618171818181618201631201819182020202119192017470Threonine, serine or cysteine nucleophile at the N-terminus of mature enzyme
12321613212632338655334479Serine or cysteine nucleophile; catalytic residues in the order Cys (or Ser), His, Glu in sequence.
111111111121111111112124Serine or threonine nucleophile; N-terminal nucleophile
4333333344237443333334414497Serine nucleophile; catalytic residues in the order Asp, His, Ser in sequence in family S8, but family S53 differs
28453036303627332135262954242924262526262546444437806Serine nucleophile; catalytic residues in the order Ser, Asp, His in sequence
111214121111118Serine nucleophile; catalytic residues in the order Ser, Lys (within the motif SXXK) in sequence
333343333333543333333333379Serine nucleophile; catalytic residues in the order Ser, Lys (or His) in sequence
112Serine nucleophile; catalytic residues in the order Ser, Lys in sequence
121217Serine nucleophile; catalytic residues in the order Ser, His, Asp in sequence
1111116Serine nucleophile; catalytic residues in the order His, Ser within the motif HXS.
233323421232354232222442671Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane
22111119Families of peptidases of unknown catalytic mechanism not assigned to clans
11111111111111111111111124
107689101197981121149899881113101312250
1113
313111332119
1113