Peptidases • Saccharomycotina
Annotations/GenomesAmbph1Artfe1_2Arxad1Ascru1Ashgo1_1Babin1Botmuc1Canalb1Canar1Canbo1Canca1Canta1Cante1Cepal1_1Cepfr1_1Citma1Clalu1_2Cybja1Debha1Dekbr2Hanpo2Hanva1_1Hypbu1IsorIO21_1Isori2Issori2Issorie2Kazaf1Klula1Kurca1Lipst1_1Lodelo1Metbi1Metbi_SCcombMetfru2Metreu1Meygui1Myxme1Nadfu1Nakbac1Nakdel1Nakwi1Ogapa1Pacta1_2Petxy1Pickud1Picme2Picpa1Picst3Sacarb1Sacca1Sacce1SacceM3707_1SacceM3836_1SacceM3837_1SacceM3838_1SacceM3839_1SacceYB210_1Satdi1Schcoi1Schque1Schseg1_1Schsti1Spaarb1Spapa3Spola1Sugame1Symat1Torde1Tripe1Wican1Wicdo1Yarli1YarliW29YarliW29_1YarliYB392YarliYB419YarliYB420YarliYB566YarliYB567YarliYlCW001Yarlip1Zyghe1_2Zygro1TotalAnnotation Description
Merops
15316020615510717114015014113414814915116116417815316715114315111115313413714414012212716020012814211525815917016715911712313915515216313413412814812716913713613513713613514311514514815115315615715320020811819018215721221721621521821621521621821418412313,304
15312110712619121141510141720201466561088108859101112525251616669105108861012435899999817109101319187192451912103539363838383738393614101,247Water nucleophile; water bound by two Asp from monomer or dimer; all endopeptidases, from eukaryote organisms, viruses or virus-like organisms
1211218Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on periplasmic side of cell membrane.
1111131121111111111311111111111111111211111222112160Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on cytoplasmic side of cell membrane.
1215211414171715121216131316141711161315141115141516151613152210141217121618161313111413131513111214141515151515151712111211121814191220131718161414141414141414141418121,212Cysteine nucleophile; catalytic residues in the order Cys, His, Asn (or Asp) in sequence
432924222212234222233342222223222222223222223222323222222222233333332342222222222222202Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
111211111111211212121112211135Cysteine nucleophile; catalytic residues in the order His, Glu (or Asp), Cys in sequence
111111111110Cysteine nucleophile; catalytic residues in the order Glu, Cys, His in sequence
11Cysteine nucleophile; catalytic residues in the order Cys, His, His in sequence
11111111111111111111111111111111111111111142Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
11121118Water nucleophile; water bound by Gln and Glu; all endopeptidases
423424343224433244334232222225334474445224443224423222222224444444462443333333333332265Families of peptidase inhibitors not assigned to clans
11111111111111115
11
11111117
111111111111111116
11211111111111111111212113111221121122222222211111111221122222222222199
222222222222242323222321111322322122112221222122231333333112322222322242222222222222174
1111111111112111111111111111121112112111111111111111111111111112211111111111111186Families of metallopeptidases not assigned to clans
11610971395899665661065666116676676106651688875666766669787777777655977961311512610109109999999136642Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Glu, His or Asp
11111111111111131111111111111111111111111111111111111112111111111111111111111181Water nucleophile; water bound by single zinc ion ligated to His, Glu (within the motif HXXE) and His
1121122121211112111123121221122111911352222212121111111211111112211312222222222211133Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HXXEH) and Glu
112Water nucleophile; water bound by two zinc ions ligated by Lys, Asp, Asp, Asp, Glu
7786477766877788877786668886467577126867667866886557555555556655777695766777777777775552Water nucleophile; water bound by two cobalt or manganese ions ligated by Asp, Asp, His, Glu, Glu
131117891491010913121415181710191414131112111011129131710101191611149151091613142011118101011910101010101051313101091081414111319141314141414141414141419111,024Water nucleophile; water bound by two zinc ions ligated by His (or Asp), Asp, Glu, Asp (or Glu), His
8345244367337448474992466661510524364844326899673342444444544323335453466444444444475392Water nucleophile; water bound by two zinc ions ligated by His, His or Asp, Lys or Glu, His, His.
111111111110Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motifs HXXXD and HXH)
22431232444444432534333333113423332334123443352322222222222333335552534444444444432255Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D)
11Water nucleophile; water bound by single zinc ion ligated to Asp, His and His.
112Asparagine nucleophile; catalytic residues in the order Asp, Asn in sequence; all self-processing endopeptidases
121111121112Serine or cysteine nucleophile; catalytic residues in the order His, Asp, Ser (or Cys) in sequence; all endopeptidases
1617211917161619161920181819182317181818181618171819181820201919161731181920201817151918191819181721182020202020202116181917171817182018181919212019211820191919202017191,568Threonine, serine or cysteine nucleophile at the N-terminus of mature enzyme
4151223332333231361323343411452262233212423333232865656521122122323333444444444341249Serine or cysteine nucleophile; catalytic residues in the order Cys (or Ser), His, Glu in sequence.
22Cysteine nucleophile at the N-terminus of mature enzyme; catalytic residues in the order Cys, Thr, His
1111111111111111111111111111211111111111111111111111111111111122222222221185Serine or threonine nucleophile; N-terminal nucleophile
44471394326333333533344132232263337633434334423333633333332643351034534431415141516151515151543417Serine nucleophile; catalytic residues in the order Asp, His, Ser in sequence in family S8, but family S53 differs
3028513116452332302329333433363530323627332135292628282426346024292254293933242224313429362724263524302526252626252520323437393128335448234644294446464646464646464637212,766Serine nucleophile; catalytic residues in the order Ser, Asp, His in sequence
12111113112214121113111111111123111421122111111111171Serine nucleophile; catalytic residues in the order Ser, Lys (within the motif SXXK) in sequence
333433323333333343333333333334333353334333333333233333333323343333333333333333333333256Serine nucleophile; catalytic residues in the order Ser, Lys (or His) in sequence
11114Serine nucleophile; catalytic residues in the order Ser, Lys in sequence
1111121122111111111123Serine nucleophile; catalytic residues in the order Ser, His, Asp in sequence
11111117Serine nucleophile; catalytic residues in the order His, Ser within the motif HXS.
11Serine nucleophile; catalytic residues in the order Ser, Glu, His
222323423221243423342123334232522232245223343323223222222213322333462443222222222262222Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane
122111111111111111111111127Families of peptidases of unknown catalytic mechanism not assigned to clans
111111111111111111111112111111111111111111111111111111111111111111111111111111111183
8101389711861010991189991011979981098881391182110101314910710987898889888881181010981010111213813101113121212121212121212129825
111111111111111116
311112213111132322112164556121167
22
1113111111111111119