Peptidases • Phycomyces nitens S608 v1.0
Annotations/GenomesChlpad1Cirumb1Cokrec1Cunech1Gonbut1Kircor1Parpar1Phaart1Phybl2PnitS607_1PnitS608_1PnitS609_1Radspe1Rhimi_ATCC52814_1Spifus1Synrac1Thaele1Zycmex1Zyghet1TotalAnnotation Description
Merops
3163272473182673672653232842672742772642322292832943343025,470
23232122243619242830323219201920232431470Water nucleophile; water bound by two Asp from monomer or dimer; all endopeptidases, from eukaryote organisms, viruses or virus-like organisms
423334324455343444468Water nucleophile; water bound by two Asp; all membrane-bound endopeptidases known only from eubacteria with active site on cytoplasmic side of cell membrane.
11Water nucleophile; water bound by two Asp
33282234283630312925282731282331343431563Cysteine nucleophile; catalytic residues in the order Cys, His, Asn (or Asp) in sequence
66674656777105656655115Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
132213233222112241239Cysteine nucleophile; catalytic residues in the order His, Glu (or Asp), Cys in sequence
1122111111111111119Cysteine nucleophile; catalytic residues in the order Cys, His, His in sequence
12121222111212223Cysteine nucleophile; catalytic residues in the order His, Cys in sequence
8775697664446746787118Families of peptidase inhibitors not assigned to clans
112
11311119
2111117
212312112
1113
221221121122211311129
241125341111311424445
11111111111111111118Families of metallopeptidases not assigned to clans
17171714121920161717151717151415261824327Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Glu, His or Asp
31127Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HXXEH) and Glu
344334453333343444670Water nucleophile; water bound by two zinc ions ligated by Lys, Asp, Asp, Asp, Glu
1211911101212121213131312121211121212223Water nucleophile; water bound by two cobalt or manganese ions ligated by Asp, Asp, His, Glu, Glu
1417813131510201513121310101114102412254Water nucleophile; water bound by two zinc ions ligated by His (or Asp), Asp, Glu, Asp (or Glu), His
9559887698785468756130Water nucleophile; water bound by two zinc ions ligated by His, His or Asp, Lys or Glu, His, His.
112113111111111121224Water nucleophile; water bound by single zinc ion ligated to two His (within the motif HEXXH) and Asp; membrane proteins with intramembrane active site.
454527555444465365588Water nucleophile; water bound by single zinc ion ligated to two His and Asp (within the motif HSHP(X)9D)
1113Asparagine nucleophile; catalytic residues in the order Asp, Asn in sequence; all self-processing endopeptidases
522413321111211123137Serine or cysteine nucleophile; catalytic residues in the order His, Asp, Ser (or Cys) in sequence; all endopeptidases
30252121223621211718182019191920202425416Threonine, serine or cysteine nucleophile at the N-terminus of mature enzyme
2247210333454222242467Serine or cysteine nucleophile; catalytic residues in the order Cys (or Ser), His, Glu in sequence.
1111116Serine or threonine nucleophile; N-terminal nucleophile
19289151012111919161515158911111814274Serine nucleophile; catalytic residues in the order Asp, His, Ser in sequence in family S8, but family S53 differs
759360847492618655565656594850766794691,311Serine nucleophile; catalytic residues in the order Ser, Asp, His in sequence
313115114121Serine nucleophile; catalytic residues in the order Ser, Lys (within the motif SXXK) in sequence
353545744554453374888Serine nucleophile; catalytic residues in the order Ser, Lys (or His) in sequence
121111133111121112126Serine nucleophile; catalytic residues in the order Ser, His, Asp in sequence
1113Serine nucleophile; catalytic residues in the order His, Ser within the motif HXS.
65510884974665467565116Serine nucleophile; transmembrane protein with catalytic residues in the order Ser, His embedded in the membrane
31116Families of peptidases of unknown catalytic mechanism not assigned to clans
2111131111111111120
20211825152420192623232327172023202115400
11
12211119
112